PerioCol-TC Fiber Product Details
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Questions and Answers

Why is it difficult to determine the most efficacious approach for adjunctive therapy?

  • Because local and systemic adjunctive therapies are mutually exclusive.
  • Because clinical outcomes are always unpredictable.
  • Because surgical therapy is always the best option.
  • Because there is not enough data available to compare different therapies. (correct)
  • What is often used to treat pocket sites that do not respond to nonsurgical therapy?

  • Systemic antimicrobials
  • Locally delivered antimicrobials
  • SRP alone
  • Surgical therapy (correct)
  • What can improve clinical outcomes after periodontal surgery?

  • Regular dental check-ups
  • SRP alone
  • The use of locally delivered, controlled-release antimicrobials (correct)
  • The use of systemic antimicrobials
  • What is peri-implantitis?

    <p>An inflammatory disease process that affects the tissues surrounding an implant</p> Signup and view all the answers

    What is a potential rationale for the use of locally delivered, controlled-release antimicrobials?

    <p>To target the local microflora in diseased implant sites</p> Signup and view all the answers

    What is a well-known risk factor for the development or progression of periodontitis?

    <p>Smoking</p> Signup and view all the answers

    What can enhance the efficacy of SRP in smokers?

    <p>Adjunctive use of locally delivered, controlled-release antimicrobials</p> Signup and view all the answers

    What is a potential advantage of adjunctive therapy for patients who smoke?

    <p>It can lessen the adverse impact of smoking on the periodontium</p> Signup and view all the answers

    What is a potential adverse effect of locally delivered, controlled-release antimicrobials?

    <p>Hypersensitivity reactions</p> Signup and view all the answers

    What is SRP?

    <p>Scalping and Root Planing</p> Signup and view all the answers

    Study Notes

    PerioCol-TC

    • Each vial contains 25 mg of fish type I collagen impregnated with 2.0 mg of tetracycline hydrochloride, sterilized by gamma radiation.
    • Releases tetracycline in vitro for 8-10 days.
    • Indicated for the treatment of adult periodontitis as an adjunct to scaling and root planing (SRP) for pockets more than 5 mm deep.
    • Biodegradable and does not require removal.

    Doxycycline Gel

    • A subgingival, controlled-release delivery product composed of a two-syringe mixing system.
    • Contains 450 mg of a bioabsorbable polymeric formulation of 36.7% poly (D,L-lactide) and 50 mg of doxycycline hyclate.
    • Indicated for the treatment of chronic adult periodontitis for a gain in clinical attachment, reduction in probing depth, and reduction of bleeding on probing.
    • Biodegradable and does not require removal.

    Ligosan Slow Release

    • A 14% (w/w) resorbable doxycycline gel for periodontal application.
    • Contains 260 mg of Ligosan Slow Release in single-application cylinder cartridges.
    • Releases doxycycline in the GCF over 12 days.
    • Mechanical hygiene in the area should be avoided for 7 days.

    Minocycline Microspheres

    • A subgingival, controlled-release delivery system containing the antibiotic minocycline hydrochloride.
    • Each cartridge delivers minocycline hydrochloride equivalent to 1 mg of minocycline free base.
    • Indicated as an adjunct to SRP for the reduction of pocket depth in patients with adult periodontitis and as part of a periodontal maintenance program.
    • Biodegradable and does not require removal.

    Rationale for Local Delivery and Controlled Release

    • Chronic adult periodontitis is a multifactorial disease involving susceptible hosts, pathogenic oral plaque microorganisms, and behavioral or environmental factors.
    • Local delivery and controlled release of antimicrobials can enhance the clinical efficacy of SRP.

    Clinical Indications

    • Combination adjunctive therapy with locally delivered, controlled-release antimicrobials and systemic therapy with low-dose doxycycline can enhance the clinical efficacy of SRP.
    • Locally delivered, controlled-release antimicrobials can improve clinical outcomes after periodontal surgery in regenerative and non-regenerative settings.
    • Peri-implantitis can be treated with locally delivered, controlled-release antimicrobials targeting the local microflora.

    Tobacco Smoking

    • Smoking is a risk factor for periodontitis and can limit the effectiveness of periodontal therapy.
    • Adjunctive therapy with locally delivered, controlled-release antimicrobials can enhance the efficacy of SRP in smokers.

    Adverse Effects and Cautions

    • Potential for hypersensitivity reactions.

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    Description

    This quiz covers the details of PerioCol-TC, a fiber-based product used in periodontal treatment, including its packaging, biodegradation, and composition. Learn about the fiber's characteristics, usage, and sterilization process.

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