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Questions and Answers
What is the key factor for sorting neuropeptides into Dense Core Vesicles (DCVs)?
What is the key factor for sorting neuropeptides into Dense Core Vesicles (DCVs)?
What is the key factor for sorting classical transmitters into synaptic vesicles?
What is the key factor for sorting classical transmitters into synaptic vesicles?
What type of receptors do neuropeptides use for transmission?
What type of receptors do neuropeptides use for transmission?
Where are classical transmitters synthesized before being packaged into synaptic vesicles?
Where are classical transmitters synthesized before being packaged into synaptic vesicles?
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What is the major difference between 'classical' and peptide transmitters in neurons?
What is the major difference between 'classical' and peptide transmitters in neurons?
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What is the function of G-protein-gated receptors in neuropeptide transmission?
What is the function of G-protein-gated receptors in neuropeptide transmission?
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What is the role of Dense Core Vesicles (DCVs) in neurotransmission?
What is the role of Dense Core Vesicles (DCVs) in neurotransmission?
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What is the significance of transporters in sorting neurotransmitters into vesicles?
What is the significance of transporters in sorting neurotransmitters into vesicles?
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What do neuropeptides not use for fast synaptic transmission?
What do neuropeptides not use for fast synaptic transmission?
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Where are neuropeptides concentrated in cells?
Where are neuropeptides concentrated in cells?
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What is the difference in the process of synthesis between classical transmitters and neuropeptides?
What is the difference in the process of synthesis between classical transmitters and neuropeptides?
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What is the core difference between neuropeptides and classical transmitters in terms of their transmission?
What is the core difference between neuropeptides and classical transmitters in terms of their transmission?
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Where are peptide transmitters processed before being packaged into regulated secretory vesicles?
Where are peptide transmitters processed before being packaged into regulated secretory vesicles?
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What type of neurotransmission is mediated by dopamine and neuropeptides?
What type of neurotransmission is mediated by dopamine and neuropeptides?
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How is fast neurotransmission initiated?
How is fast neurotransmission initiated?
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Where are synaptic vesicles transported from before being reused?
Where are synaptic vesicles transported from before being reused?
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Which type of vesicles are released only after specific stimuli and cannot be recycled once peptides are released?
Which type of vesicles are released only after specific stimuli and cannot be recycled once peptides are released?
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How are proteins sorted into regulated secretory vesicles?
How are proteins sorted into regulated secretory vesicles?
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What are chromogranins and where do they aggregate?
What are chromogranins and where do they aggregate?
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How are neuropeptides cleaved from precursor proteins?
How are neuropeptides cleaved from precursor proteins?
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What processing does amidation refer to in neuropeptides?
What processing does amidation refer to in neuropeptides?
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Where do different processing enzymes cleave neuropeptides?
Where do different processing enzymes cleave neuropeptides?
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What does the egg-laying hormone illustrate?
What does the egg-laying hormone illustrate?
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Study Notes
Synthesis and Processing of Peptide Transmitters
- Peptide transmitters are synthesized through translation and processed in the endoplasmic reticulum (ER) and Golgi before being packaged into regulated secretory vesicles at the trans-Golgi network (TGN).
- Dopamine (DOPINE) and neuropeptides mediate slow neurotransmission, while classical transmitters like glutamate receptors can mediate both fast and slow neurotransmission.
- Fast neurotransmission is initiated by ligand-gated ion channels, while slow neurotransmission is initiated by G-protein linked receptors, altering second messengers.
- Synaptic vesicles are not newly formed from the TGN but are transported with other axonal proteins in axonal transport vesicles and are reused multiple times.
- Regulated secretory vesicles, dense core vesicles, and secretory granules are specialized vesicles in endocrine cells and neurons, released only after specific stimuli and cannot be recycled once peptides are released.
- Proteins are sorted into regulated secretory vesicles through aggregation at the TGN, facilitated aggregation, sorting by retention, and association with lipid rafts.
- Chromogranins are acidic proteins that aggregate in the TGN, and their removal affects the formation of dense core vesicles.
- Neuropeptides are always cleaved off a precursor protein, and they have di-basic cleavage sites on either side.
- Neuropeptides have a signal sequence for insertion into the ER through secretory vesicles and may have a glycine signal for amidation.
- Neuropeptides undergo processing including signal sequence cleavage in the ER, endoproteolytic cleavage in the TGN or secretory vesicle, and peptidyl-glycine-alpha-amidation in the vesicle.
- Different processing enzymes cleave neuropeptides in distinct compartments, and the timing of cleavage is important for sorting them.
- The egg-laying hormone is an example that illustrates the importance of timing in the cleavage of neuropeptides.
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Description
Test your knowledge of the synthesis and processing of peptide transmitters with this quiz. Explore topics such as the formation of synaptic vesicles, the role of neuropeptides in neurotransmission, and the mechanisms of peptide sorting and cleavage. Perfect for students and professionals in neuroscience, biochemistry, and pharmacology.