أسئلة السادسة جراحة ثالثة الدلتا

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Questions and Answers

Which of the following locations is LEAST likely to develop a peptic ulcer?

  • Duodenum
  • Jejunum (in Zollinger-Ellison syndrome or post-gastrojejunostomy)
  • Stomach
  • Sigmoid colon (correct)

A patient with cerebral trauma develops a peptic ulcer. What type of ulcer is most likely?

  • Drug-induced ulcer
  • Stress ulcer
  • Curling's ulcer
  • Cushing's ulcer (correct)

Which characteristic is most indicative of an acute peptic ulcer?

  • Presenting with hour-glass stomach
  • Association with Helicobacter pylori infection
  • Deep invasion into the serosa
  • Superficial erosion of the mucosa (correct)

What is the primary mechanism by which duodeno-gastric reflux contributes to gastric ulcer formation?

<p>Increasing destruction of gastric mucosa (C)</p> Signup and view all the answers

How does Helicobacter pylori contribute to the formation of peptic ulcers?

<p>By producing substances that damage the gastric and duodenal mucosa (D)</p> Signup and view all the answers

Which of the following is a characteristic of duodenal ulcers but NOT gastric ulcers?

<p>More common in males than females (B)</p> Signup and view all the answers

A patient presents with a peptic ulcer. Endoscopy reveals an ulcer on the lesser curve of the stomach. What is a contributing factor to ulcer formation at this site?

<p>Frequent trauma from food (D)</p> Signup and view all the answers

A patient's ulcer base is described as deeply penetrating, reaching the serosa. What is the primary concern with this characteristic?

<p>Potential for perforation and damage to nearby organs (C)</p> Signup and view all the answers

Which complication is more commonly associated with duodenal ulcers compared to gastric ulcers?

<p>Melena (C)</p> Signup and view all the answers

What is the most likely cause of pain that wakes a patient in the middle of the night (nocturnal pain)?

<p>Duodenal ulcer due to an empty stomach (D)</p> Signup and view all the answers

Which of the following is MOST suggestive of a peptic ulcer caused by Zollinger-Ellison Syndrome (ZES)?

<p>Multiple ulcers located in the distal duodenum and proximal jejunum (D)</p> Signup and view all the answers

What laboratory finding is most indicative of Zollinger-Ellison syndrome (ZES) as a cause of peptic ulcer disease?

<p>Elevated serum gastrin levels (over 500 pg/ml) (D)</p> Signup and view all the answers

What is the primary purpose of performing a biopsy during an upper GI endoscopy for a patient with a peptic ulcer?

<p>To determine if the ulcer is benign or malignant (B)</p> Signup and view all the answers

A patient presents with symptoms suggestive of a peptic ulcer. The physician orders a barium meal. What is the MAIN reason for using this diagnostic method?

<p>To visualize the ulcer and assess its size and location (C)</p> Signup and view all the answers

A patient is diagnosed with gastritis and a possible peptic ulcer. Which test would directly identify the presence of Helicobacter pylori in the ulcer?

<p>Urease test on a biopsy sample (A)</p> Signup and view all the answers

What distinguishes a Cushing's ulcer from a Curling's ulcer?

<p>Cushing's ulcers occur after cerebral trauma, while Curling's ulcers occur after major burns. (A)</p> Signup and view all the answers

How does smoking contribute to the development of gastric ulcers?

<p>By impairing gastric emptying and increasing duodenogastric reflux (A)</p> Signup and view all the answers

A patient presents with a peptic ulcer and a history of chronic cholecystitis. Which of the following ADDITIONAL conditions would complete Wilkie's Triad?

<p>Appendicitis (D)</p> Signup and view all the answers

Which of the following characteristics is more typical of gastric ulcers compared to duodenal ulcers?

<p>Hematemesis is more common than melena (A)</p> Signup and view all the answers

A 55-year-old male presents with epigastric pain that worsens soon after eating. Endoscopy reveals a gastric ulcer. Further evaluation reveals normal gastric acid production. Which of the following is the MOST likely underlying mechanism for this patient's ulcer?

<p>Impaired mucosal defense (D)</p> Signup and view all the answers

A patient with a history of peptic ulcer disease presents with sudden, severe abdominal pain and signs of peritonitis. Which of the following is the MOST likely complication?

<p>Perforation (C)</p> Signup and view all the answers

A patient with a duodenal ulcer is found to have pyloric stenosis. What is the primary mechanism leading to this complication?

<p>Inflammation and scarring from chronic ulceration (B)</p> Signup and view all the answers

Following an upper endoscopy and biopsy, a patient is diagnosed with a benign gastric ulcer. However, the gastroenterologist emphasizes the need for repeat endoscopy and biopsy after a course of treatment. What is the MOST important reason for this follow-up?

<p>To ensure complete healing of the ulcer and rule out malignancy (D)</p> Signup and view all the answers

A patient presents with symptoms suggestive of a peptic ulcer, and the physician suspects Zollinger-Ellison syndrome (ZES). Besides measuring serum gastrin levels, which of the following tests would be MOST helpful in confirming the diagnosis?

<p>Secretin stimulation test (C)</p> Signup and view all the answers

In the context of peptic ulcer disease, what is the 'pointing sign'?

<p>Ability of the patient to localize the location of the pain (D)</p> Signup and view all the answers

What is the underlying mechanism for the pain relief experienced after eating a meal in a patient with a duodenal ulcer?

<p>Buffering of gastric acid by food (B)</p> Signup and view all the answers

A patient with chronic peptic ulcer disease develops a gastric outlet obstruction. Which of the following is the MOST likely cause of this obstruction:

<p>Edema and inflammation (C)</p> Signup and view all the answers

In a patient presenting with upper gastrointestinal bleeding due to a peptic ulcer, which clinical sign would suggest a duodenal ulcer as the source of the bleeding rather than a gastric ulcer?

<p>Melena (B)</p> Signup and view all the answers

A patient presents with symptoms of peptic ulcer disease. The gastroenterologist suspects it might be related to excessive use of NSAIDs. By what primary mechanism do NSAIDs contribute to ulcer formation?

<p>Inhibiting prostaglandin synthesis (C)</p> Signup and view all the answers

In the context of peptic ulcer disease, what is the primary reason for performing an emergency fiber-optic gastroscopy?

<p>To immediately identify and manage the source of acute bleeding or perforation. (B)</p> Signup and view all the answers

A patient presents with a history of chronic NSAID use and is suspected of having a drug-induced peptic ulcer. Which of the following best describes the initial prophylactic approach?

<p>Avoiding all predisposing causes, such as discontinuing NSAID use if possible. (D)</p> Signup and view all the answers

A patient undergoing treatment for a duodenal ulcer reports persistent symptoms despite adherence to a proton pump inhibitor regimen. Further investigation reveals multiple ulcers in the distal duodenum and proximal jejunum. Which of the following conditions is MOST likely?

<p>Zollinger-Ellison syndrome (C)</p> Signup and view all the answers

What is the underlying mechanism by which Helicobacter pylori contributes to duodenal ulcer formation?

<p>Decreasing secretion of pancreaticoduodenal bicarbonate, leading to increased acidity. (C)</p> Signup and view all the answers

Which of the following is the MOST accurate description of the typical shape and appearance of a chronic peptic ulcer?

<p>Deeply penetrating ulcer with sloping or punched-out edges and irregular shape due to fibrosis. (D)</p> Signup and view all the answers

A patient presents with a gastric ulcer located on the lesser curvature of the stomach. Which of the following factors is MOST likely to contribute to ulcer formation at this specific site?

<p>Reduced vascularity compared to the greater curvature. (C)</p> Signup and view all the answers

A patient with a long-standing duodenal ulcer develops persistent vomiting, leading to dehydration and electrolyte imbalance. What is the MOST likely underlying mechanism for this complication?

<p>Pyloric stenosis caused by chronic inflammation and scarring. (B)</p> Signup and view all the answers

A patient with a known peptic ulcer presents with sudden, severe abdominal pain, board-like rigidity, and rebound tenderness. Which of the following is the MOST appropriate immediate next step in management?

<p>Perform an upright chest X-ray to evaluate for free air. (B)</p> Signup and view all the answers

In a patient with a duodenal ulcer, which of the following physiological mechanisms is primarily responsible for the nocturnal pain that often occurs?

<p>Gastric acid secretion in the absence of food buffering. (C)</p> Signup and view all the answers

What is the primary rationale for obtaining multiple biopsies (4-8 quadrants) from the edge of a gastric ulcer during an upper endoscopy?

<p>To differentiate between benign and malignant ulcers. (C)</p> Signup and view all the answers

A patient with a history of peptic ulcer disease presents with anemia. Lab results reveal iron deficiency. Which of the following is the MOST likely cause of the anemia in this patient?

<p>Chronic blood loss from the ulcer. (D)</p> Signup and view all the answers

In patients with peptic ulcer disease, what is the significance of the "pointing sign" during physical examination?

<p>It helps localize the area of maximum pain and tenderness. (C)</p> Signup and view all the answers

Which of the following best describes the rationale behind avoiding irritant foods, alcohol, smoking, and stress in the management of peptic ulcer disease?

<p>They increase gastric acid secretion and impair mucosal defense mechanisms. (D)</p> Signup and view all the answers

A patient presents with epigastric pain relieved by eating. Endoscopy reveals a duodenal ulcer. What is the MOST likely mechanism for the pain relief associated with food consumption?

<p>Buffering of gastric acid by the ingested food. (B)</p> Signup and view all the answers

A patient is suspected of having Zollinger-Ellison syndrome (ZES). What serum gastrin level would be MOST suggestive of this diagnosis?

<blockquote> <p>500 pg/mL (C)</p> </blockquote> Signup and view all the answers

Which factor differentiates a Cushing's ulcer from a Curling's ulcer in the context of acute peptic ulcer development?

<p>Cushing's ulcers occur after cerebral trauma, while Curling's ulcers are associated with major burns. (D)</p> Signup and view all the answers

What is the MOST likely long-term consequence of chronic duodeno-gastric reflux in the development of gastric ulcers?

<p>Chronic irritation and inflammation of the gastric mucosa, impairing its protective mechanisms. (C)</p> Signup and view all the answers

A patient presents with symptoms of a peptic ulcer, and the physician suspects H. pylori infection. Which of the following tests allows for simultaneous detection of the bacteria and assessment of antibiotic sensitivity?

<p>Culture (D)</p> Signup and view all the answers

While assessing a patient suspected of a peptic ulcer, which clinical finding would MOST strongly suggest a duodenal location over a gastric location?

<p>Melena greater than hematemesis (C)</p> Signup and view all the answers

A patient with chronic peptic ulcer disease develops a gastric outlet obstruction. Which of the following mechanisms MOST directly contributes to this obstruction?

<p>Edema and inflammation of the pyloric channel due to recurrent ulceration. (A)</p> Signup and view all the answers

According to the information provided, which of the following conditions constitutes Saint's triad?

<p>Chronic cholecystitis, hiatal hernia, and colonic diverticulosis. (D)</p> Signup and view all the answers

Which of the following is the MOST critical factor in the pathogenesis of gastric ulcers associated with chronic ischaemia?

<p>Impaired gastric mucosal reconstruction due to reduced blood supply. (A)</p> Signup and view all the answers

What is the PRIMARY action of urease, an enzyme produced by Helicobacter pylori, that contributes to gastric mucosal damage?

<p>Hydrolyzing urea to produce ammonia, neutralizing gastric acid. (B)</p> Signup and view all the answers

A patient is diagnosed with a gastric ulcer. The ulcer is located in the antral part of the stomach. Which pathological process is MOST likely to initiate ulcer development in this region?

<p>Duodenogastric reflux causing injury to the mucosa. (B)</p> Signup and view all the answers

A 30-year-old male presents with recurrent peptic ulcers despite eradication therapy for H. pylori. He has no history of NSAID use or smoking. Which of the following genetic predispositions would raise suspicion for Multiple Endocrine Neoplasia type 1 (MEN1) related Zollinger-Ellison syndrome?

<p>A strong family history of peptic ulcers and hypercalcemia (D)</p> Signup and view all the answers

A patient with a hx of peptic ulcer disease presents with epigastric pain that is exacerbated by eating but relieved with the use of antacids. Which clinical characteristic MOST strongly suggests that the ulcer is gastric rather than duodenal in origin?

<p>Hematemesis greater than melena (D)</p> Signup and view all the answers

A patient undergoing an endoscopy for a suspected peptic ulcer is found to have a large, deeply penetrating ulcer with significant surrounding inflammation. The gastroenterologist describes the surrounding mucosa as converging towards the ulcer. What specific characteristic of the ulcer is being described?

<p>Margin (B)</p> Signup and view all the answers

Flashcards

Peptic Ulcer Definition

Ulcer that is bathed in acid (HCL).

Peptic Ulcer Sites

DU (Duodenal Ulcer), GU (Gastric Ulcer), Jejunum, Lower end esophagus, Terminal ileum

Drug-induced Ulcers

Steroids & NSAIDs.

Stress Ulcers

Hypotension from Hemorrhage.

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Cushing's Ulcer

After cerebral trauma.

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Curling's Ulcer

After major burns.

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Acute Peptic Ulcer Number

Multiple

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Acute Peptic Ulcer Site

Antrum of stomach more often than the duodenum.

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Acute Peptic Ulcer Characters

Superficial, rarely invading mucosa

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Peptic Ulcer Prophylaxis

Avoid all predisposing causes.

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Prophylaxis for Peptic Ulcers

Avoid all predisposing causes.

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Curative Treatment of Peptic Ulcers

Essentially conservative.

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Gastric Ulcer Age

40-60 years

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Gender in Gastric Ulcers

Male and Female are equally affected

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Genetic Predisposition of Gastric Ulcers

More in -ve blood group

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Increasing Destruction of Gastric Mucosa

Duodeno-gastric reflux, Antral stasis, Smoking, Trauma, Infection (H. pylori)

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Urease Enzyme

H. pylori hydrolyzes urea to CO2 and ammonia.

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Decreasing Reconstruction of Gastric Mucosa

Ischaemic Theory, Malnutrition, Vitamin A & C Deficiency

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Duodenal Ulcer Etiology

↑↑ parietal cell mass, ↑↑ vagal tone, ↑↑↑ gastrin hormone, ↑↑ Histamine, Trauma, Infection

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Increased Vagal Tone

Tall, Thin and Tense individuals

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Duodenum site

Duodenum is the commonest site

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Stomach site

Lesser curve (ulcer-bearing area) because of food trauma

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GI Bleeding

History of GI Bleeding

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Peptic Ulcer Investigation

Emergency fibre-optic gastroscopy.

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Peptic Ulcer Perforation

DUODENAL ULCER is more common

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DU location and Stenosis

gastric outlet obstruction

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GU location and Stenosis

Hour- Glass or Tea-pot stomach.

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GU Malignancy

GU may turn malignant less than 0.5%

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Peptic Ulcer Number

single, Multiple ulcers may occur in Z.E syndrome.

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Prevalence between genders for Duodenal Ulcers

Male to female: 3:1

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Genetic Predisposition Duodenal Ulcers

More in blood group O

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Zollinger-Ellison syndrome

↑serum gastrin

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Hyperparathyroidism

Hypercalcemia

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Liver cirrhosis

leads to lack of inactivation of gastrin and histamine.

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Peptic Ulcer Shape

Rounded or oval but usually irregular due to fibrosis.

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Peptic Ulcer Edges

Sloping or punched out.

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Peptic Ulcer Floor

covered by easily bleeding granulation tissue.

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Peptic Ulcer Margin

Surrounding mucosa converge on ulcer as a result of scarring

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Peptic Ulcer Base

deeply penetrating reaching to serosa and may perforates nearby organs.

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Pointing sign

Patient can localize the point of maximum pain

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Resistant ulcers

to treatment with H2 receptor blockers.

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Ulcers in unusual sites

as distal duodenum and proximal jejunum.

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Weight loss

Hematemesis > melena

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Weight loss

Melena > Hematemesis

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Study Notes

  • An ulcer is bathed in acid (HCL)

Sites for Peptic Ulcers

  • DU
  • GU
  • Jejunum: in ZES and gastrojejunostomy
  • Lower end esophagus: in GERD
  • Terminal ileum: in Meckel's diverticulum containing heterotopic gastric epithelium

Acute Peptic Ulcers

  • Drug induced ulcers are caused by steroids and NSAIDs
  • Stress Ulcers are caused by hypotension from hemorrhage
  • Cushing's Ulcer happens after cerebral trauma
  • Curling's Ulcer happens after major burns

Pathology of Acute Peptic Ulcers

  • Multiple in numbers
  • Located at ant part of the stomach, most often the duodenum
  • Superficial in character rarely invading mucosa

Clinical Picture of Acute Peptic Ulcers

  • Varies from mild dyspepsia to severe attack of haematemsis or perforation of the ulcer

Investigations of Acute Peptic Ulcers

  • Emergency fibre-optic gastroscopy

Treatment of Acute Peptic Ulcers

  • Prophylaxis: Avoid all predisposing causes
  • Curative: Essentially conservative, conservative, interventional and finally surgery

Chronic Peptic Ulcer Etiology

Gastric Ulcer

  • Age is most often 40-60 years
  • Gender is more common in females
  • Negative Family History
  • More common in -ve blood group

Duodenal Ulcer

  • Age is most often 20-40 years
  • Gender is more common in males at a rate of 3:1
  • Positive Family History
  • More common in O blood group

Precipitating Factors

  • Gastric Ulcer (Devitalization of Mucosa)
  • Increasing Destruction of Gastric Mucosa due to Duodeno-gastric reflux (Cooper's theory)
  • Increasing Destruction of Gastric Mucosa due to Antral stasis (Dragstedt theory)
  • Increasing Destruction of Gastric Mucosa due to Smoking
  • Increasing Destruction of Gastric Mucosa due to Trauma by irritant food includes spices, coffee, tea, alcohol and ulcerogenic drugs
  • Increasing Destruction of Gastric Mucosa due to Infection by Helicobacter pylori: G-ve bacilli which is adherent to antral mucosa
  • It produces substances that damage gastric and duodenal mucosa such as Urease enzyme, it hydrolyzes urea to CO2 & ammonia which is a strong alkali that damages the mucosa and Proteases enzyme, it degrades the protective mucus layer

Decreasing Reconstruction of Gastric Mucosa Due To:

  • Ischaemic theory: a decrease in blood supply as in old atherosclerotic patients and IHD
  • Malnutrition: Deficiency of proteins
  • Deficiency of Vitamins A and C

II) Deuodenal Ulcer (Hyperacidity)

  • ↑↑ parietal cell mass: (hyperplasia)
  • ↑↑ vagal tone: as in Tall, Thin and Tense individuals
  • ↑↑↑ gastrin hormone:
    • Zollinger-Ellison's syndrome
    • Hyperparathyroidism → Hypercalcemia which increase gastric acid secretion - Liver cirrhosis leads to the lack of inactivation of gastrin and histamine
  • ↑↑ Histamine (Allergic theory): Ag/Ab reaction
  • Trauma by irritant food, increases gastric acidity
  • Infection by Helicobacter causes a decrease in secretion of pancreaticoduodenal bicarbonate

Pathology

  • Number of ulcers is usually single; multiple can occur in Z.E Syndrome
  • The most common site is the Duodenum: a Bulbar ulcer is in antero-superior aspect of 1st inch of 1st part of duodenum, it's the site of antral jets or Stomach a Lesser curve (ulcer-bearing area), because of food trauma and lesser curvature less vascular than greater curve
  • Size is usually less than one inch (GU larger than D.U)
  • Shape is Rounded or oval but usually irregular due to fibrosis
  • Edges are Sloping or punched out
  • Floor is covered by easily bleeding granulation tissue
  • Base is deeply penetrating reaching to serosa and may perforates nearby organs
  • Margin: Surrounding mucosa converge on ulcer as a result of scarring

Complications

  • Bleeding which is more common in D.U. than G.U, haematemsis is commoner in GU or melena is commoner in D.U or Both
  • Perforation which is more common in DU > GU
  • Stenosis: GU is Hour- Glass or Tea-pot stomach or DU is Pyloric stenosis. (Gastric outlet obstruction)
  • Malignancy where GU may turn malignant in less than 0.5% but never in DU

Clinical Picture

Gastric Ulcer

  • Deep-seated burning pain located Epigastric to the left of the midline and has a Retrostenal heartburn radiation around half an hour to 1 hour after meals which is increased by Irritant foods, alcohol, smoking & stress but decreased by Vomiting
  • Vomiting is Common, self-induced and has a tendency to occur during spring, winter & autumn periods of ulcer activity followed by freedom periods from 2-6 months where the patient is completely free
  • Patient has Good appetite but is afraid to eat from pain resulting in Weight loss and Hematemesis > melena, caused by reflex inhibition of intestinal motility by pain OR pylorospasm
  • Pointing sign is when a patient can localize the point of maximum pain
  • Presence of Localized deep tenderness at that point Just to the left of midline

Duodenal Ulcer

  • Deep-seated burning pain located Epigastric to the right of the midline and has around 2 hours after meals radiation, patients also have Hunger pain around 1/2-1 hour before next meal or pain that wakes the patient in midnight the pain is increased by Hunger but decreased by Alkalis & antacids or Eating small frequent meal
  • Vomiting is Rare, except when pyloric stenosis occurred and has a tendency to occur during spring, winter & autumn periods of ulcer activity followed by freedom periods from 2-6 months where the patient is completely free
  • Patient has Good appetite when patient eats frequent small meals, also has Over weight and Melena > Hematemesis, caused by reflex inhibition of intestinal motility by pain OR pylorospasm
  • Pointing sign is when a patient can localize the point of maximum pain
  • Presence of Localized deep tenderness at that point Just to the right of midline is caused by reflex inhibition of intestinal motility by pain OR pylorospasm

PU of ZES is suspected clinically by

  • Resistant ulcers to treatment with H2 receptor blockers
  • Recurrent ulcers
  • Multiple ulcers
  • Ulcers in unusual sites as distal duodenum and proximal jejunum
  • Peptic ulcers at the extremes of age
  • Peptic ulcers with a strong family history of ulcer disease of MEN syndrome
  • Wilkie's Triad which is Chronic Cholecystitis + Peptic ulcer + Appendicitis
  • Saint's triad is Chronic Cholecystitis + H.H. + Colonic diverticulosis

Investigations

  • CBC: iron deficiency anemia due to chronic blood loss
  • Stools: Occult blood is present (Benzedine test- Guaicum test)
  • Estimation of serum gastrin (N up to 100 pg/ml) can be diagnostic if > 500 pg/ml for Z.E.S
  • Gastric function tests: Hyperacidity in D.U. and Normal or hypoacidity in GU.
  • Radiological investigations uses a Barium meal to visualize the ulcer
  • Upper GIT Endoscopy + Biopsy uses a 4 or 8 quadrants biopsy from ulcer edge by endoscopy or Exfoliative Cytology done from gastric wash or Brush cytology
  • Investigation to Detect H. Pylori uses a Urease test by applying Urea & reagent on the ulcer, if color is changed its helicobacter pylori, Serology is done by detection of specific antibodies or Culture is used in detection of organisms

Differential Diagnosis

  • From other causes of dyspepsia & haematemsis
  • Difference between benign & malignant ulcer

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