Podcast
Questions and Answers
Which of the following locations is LEAST likely to develop a peptic ulcer?
Which of the following locations is LEAST likely to develop a peptic ulcer?
- Duodenum
- Jejunum (in Zollinger-Ellison syndrome or post-gastrojejunostomy)
- Stomach
- Sigmoid colon (correct)
A patient with cerebral trauma develops a peptic ulcer. What type of ulcer is most likely?
A patient with cerebral trauma develops a peptic ulcer. What type of ulcer is most likely?
- Drug-induced ulcer
- Stress ulcer
- Curling's ulcer
- Cushing's ulcer (correct)
Which characteristic is most indicative of an acute peptic ulcer?
Which characteristic is most indicative of an acute peptic ulcer?
- Presenting with hour-glass stomach
- Association with Helicobacter pylori infection
- Deep invasion into the serosa
- Superficial erosion of the mucosa (correct)
What is the primary mechanism by which duodeno-gastric reflux contributes to gastric ulcer formation?
What is the primary mechanism by which duodeno-gastric reflux contributes to gastric ulcer formation?
How does Helicobacter pylori contribute to the formation of peptic ulcers?
How does Helicobacter pylori contribute to the formation of peptic ulcers?
Which of the following is a characteristic of duodenal ulcers but NOT gastric ulcers?
Which of the following is a characteristic of duodenal ulcers but NOT gastric ulcers?
A patient presents with a peptic ulcer. Endoscopy reveals an ulcer on the lesser curve of the stomach. What is a contributing factor to ulcer formation at this site?
A patient presents with a peptic ulcer. Endoscopy reveals an ulcer on the lesser curve of the stomach. What is a contributing factor to ulcer formation at this site?
A patient's ulcer base is described as deeply penetrating, reaching the serosa. What is the primary concern with this characteristic?
A patient's ulcer base is described as deeply penetrating, reaching the serosa. What is the primary concern with this characteristic?
Which complication is more commonly associated with duodenal ulcers compared to gastric ulcers?
Which complication is more commonly associated with duodenal ulcers compared to gastric ulcers?
What is the most likely cause of pain that wakes a patient in the middle of the night (nocturnal pain)?
What is the most likely cause of pain that wakes a patient in the middle of the night (nocturnal pain)?
Which of the following is MOST suggestive of a peptic ulcer caused by Zollinger-Ellison Syndrome (ZES)?
Which of the following is MOST suggestive of a peptic ulcer caused by Zollinger-Ellison Syndrome (ZES)?
What laboratory finding is most indicative of Zollinger-Ellison syndrome (ZES) as a cause of peptic ulcer disease?
What laboratory finding is most indicative of Zollinger-Ellison syndrome (ZES) as a cause of peptic ulcer disease?
What is the primary purpose of performing a biopsy during an upper GI endoscopy for a patient with a peptic ulcer?
What is the primary purpose of performing a biopsy during an upper GI endoscopy for a patient with a peptic ulcer?
A patient presents with symptoms suggestive of a peptic ulcer. The physician orders a barium meal. What is the MAIN reason for using this diagnostic method?
A patient presents with symptoms suggestive of a peptic ulcer. The physician orders a barium meal. What is the MAIN reason for using this diagnostic method?
A patient is diagnosed with gastritis and a possible peptic ulcer. Which test would directly identify the presence of Helicobacter pylori in the ulcer?
A patient is diagnosed with gastritis and a possible peptic ulcer. Which test would directly identify the presence of Helicobacter pylori in the ulcer?
What distinguishes a Cushing's ulcer from a Curling's ulcer?
What distinguishes a Cushing's ulcer from a Curling's ulcer?
How does smoking contribute to the development of gastric ulcers?
How does smoking contribute to the development of gastric ulcers?
A patient presents with a peptic ulcer and a history of chronic cholecystitis. Which of the following ADDITIONAL conditions would complete Wilkie's Triad?
A patient presents with a peptic ulcer and a history of chronic cholecystitis. Which of the following ADDITIONAL conditions would complete Wilkie's Triad?
Which of the following characteristics is more typical of gastric ulcers compared to duodenal ulcers?
Which of the following characteristics is more typical of gastric ulcers compared to duodenal ulcers?
A 55-year-old male presents with epigastric pain that worsens soon after eating. Endoscopy reveals a gastric ulcer. Further evaluation reveals normal gastric acid production. Which of the following is the MOST likely underlying mechanism for this patient's ulcer?
A 55-year-old male presents with epigastric pain that worsens soon after eating. Endoscopy reveals a gastric ulcer. Further evaluation reveals normal gastric acid production. Which of the following is the MOST likely underlying mechanism for this patient's ulcer?
A patient with a history of peptic ulcer disease presents with sudden, severe abdominal pain and signs of peritonitis. Which of the following is the MOST likely complication?
A patient with a history of peptic ulcer disease presents with sudden, severe abdominal pain and signs of peritonitis. Which of the following is the MOST likely complication?
A patient with a duodenal ulcer is found to have pyloric stenosis. What is the primary mechanism leading to this complication?
A patient with a duodenal ulcer is found to have pyloric stenosis. What is the primary mechanism leading to this complication?
Following an upper endoscopy and biopsy, a patient is diagnosed with a benign gastric ulcer. However, the gastroenterologist emphasizes the need for repeat endoscopy and biopsy after a course of treatment. What is the MOST important reason for this follow-up?
Following an upper endoscopy and biopsy, a patient is diagnosed with a benign gastric ulcer. However, the gastroenterologist emphasizes the need for repeat endoscopy and biopsy after a course of treatment. What is the MOST important reason for this follow-up?
A patient presents with symptoms suggestive of a peptic ulcer, and the physician suspects Zollinger-Ellison syndrome (ZES). Besides measuring serum gastrin levels, which of the following tests would be MOST helpful in confirming the diagnosis?
A patient presents with symptoms suggestive of a peptic ulcer, and the physician suspects Zollinger-Ellison syndrome (ZES). Besides measuring serum gastrin levels, which of the following tests would be MOST helpful in confirming the diagnosis?
In the context of peptic ulcer disease, what is the 'pointing sign'?
In the context of peptic ulcer disease, what is the 'pointing sign'?
What is the underlying mechanism for the pain relief experienced after eating a meal in a patient with a duodenal ulcer?
What is the underlying mechanism for the pain relief experienced after eating a meal in a patient with a duodenal ulcer?
A patient with chronic peptic ulcer disease develops a gastric outlet obstruction. Which of the following is the MOST likely cause of this obstruction:
A patient with chronic peptic ulcer disease develops a gastric outlet obstruction. Which of the following is the MOST likely cause of this obstruction:
In a patient presenting with upper gastrointestinal bleeding due to a peptic ulcer, which clinical sign would suggest a duodenal ulcer as the source of the bleeding rather than a gastric ulcer?
In a patient presenting with upper gastrointestinal bleeding due to a peptic ulcer, which clinical sign would suggest a duodenal ulcer as the source of the bleeding rather than a gastric ulcer?
A patient presents with symptoms of peptic ulcer disease. The gastroenterologist suspects it might be related to excessive use of NSAIDs. By what primary mechanism do NSAIDs contribute to ulcer formation?
A patient presents with symptoms of peptic ulcer disease. The gastroenterologist suspects it might be related to excessive use of NSAIDs. By what primary mechanism do NSAIDs contribute to ulcer formation?
In the context of peptic ulcer disease, what is the primary reason for performing an emergency fiber-optic gastroscopy?
In the context of peptic ulcer disease, what is the primary reason for performing an emergency fiber-optic gastroscopy?
A patient presents with a history of chronic NSAID use and is suspected of having a drug-induced peptic ulcer. Which of the following best describes the initial prophylactic approach?
A patient presents with a history of chronic NSAID use and is suspected of having a drug-induced peptic ulcer. Which of the following best describes the initial prophylactic approach?
A patient undergoing treatment for a duodenal ulcer reports persistent symptoms despite adherence to a proton pump inhibitor regimen. Further investigation reveals multiple ulcers in the distal duodenum and proximal jejunum. Which of the following conditions is MOST likely?
A patient undergoing treatment for a duodenal ulcer reports persistent symptoms despite adherence to a proton pump inhibitor regimen. Further investigation reveals multiple ulcers in the distal duodenum and proximal jejunum. Which of the following conditions is MOST likely?
What is the underlying mechanism by which Helicobacter pylori contributes to duodenal ulcer formation?
What is the underlying mechanism by which Helicobacter pylori contributes to duodenal ulcer formation?
Which of the following is the MOST accurate description of the typical shape and appearance of a chronic peptic ulcer?
Which of the following is the MOST accurate description of the typical shape and appearance of a chronic peptic ulcer?
A patient presents with a gastric ulcer located on the lesser curvature of the stomach. Which of the following factors is MOST likely to contribute to ulcer formation at this specific site?
A patient presents with a gastric ulcer located on the lesser curvature of the stomach. Which of the following factors is MOST likely to contribute to ulcer formation at this specific site?
A patient with a long-standing duodenal ulcer develops persistent vomiting, leading to dehydration and electrolyte imbalance. What is the MOST likely underlying mechanism for this complication?
A patient with a long-standing duodenal ulcer develops persistent vomiting, leading to dehydration and electrolyte imbalance. What is the MOST likely underlying mechanism for this complication?
A patient with a known peptic ulcer presents with sudden, severe abdominal pain, board-like rigidity, and rebound tenderness. Which of the following is the MOST appropriate immediate next step in management?
A patient with a known peptic ulcer presents with sudden, severe abdominal pain, board-like rigidity, and rebound tenderness. Which of the following is the MOST appropriate immediate next step in management?
In a patient with a duodenal ulcer, which of the following physiological mechanisms is primarily responsible for the nocturnal pain that often occurs?
In a patient with a duodenal ulcer, which of the following physiological mechanisms is primarily responsible for the nocturnal pain that often occurs?
What is the primary rationale for obtaining multiple biopsies (4-8 quadrants) from the edge of a gastric ulcer during an upper endoscopy?
What is the primary rationale for obtaining multiple biopsies (4-8 quadrants) from the edge of a gastric ulcer during an upper endoscopy?
A patient with a history of peptic ulcer disease presents with anemia. Lab results reveal iron deficiency. Which of the following is the MOST likely cause of the anemia in this patient?
A patient with a history of peptic ulcer disease presents with anemia. Lab results reveal iron deficiency. Which of the following is the MOST likely cause of the anemia in this patient?
In patients with peptic ulcer disease, what is the significance of the "pointing sign" during physical examination?
In patients with peptic ulcer disease, what is the significance of the "pointing sign" during physical examination?
Which of the following best describes the rationale behind avoiding irritant foods, alcohol, smoking, and stress in the management of peptic ulcer disease?
Which of the following best describes the rationale behind avoiding irritant foods, alcohol, smoking, and stress in the management of peptic ulcer disease?
A patient presents with epigastric pain relieved by eating. Endoscopy reveals a duodenal ulcer. What is the MOST likely mechanism for the pain relief associated with food consumption?
A patient presents with epigastric pain relieved by eating. Endoscopy reveals a duodenal ulcer. What is the MOST likely mechanism for the pain relief associated with food consumption?
A patient is suspected of having Zollinger-Ellison syndrome (ZES). What serum gastrin level would be MOST suggestive of this diagnosis?
A patient is suspected of having Zollinger-Ellison syndrome (ZES). What serum gastrin level would be MOST suggestive of this diagnosis?
Which factor differentiates a Cushing's ulcer from a Curling's ulcer in the context of acute peptic ulcer development?
Which factor differentiates a Cushing's ulcer from a Curling's ulcer in the context of acute peptic ulcer development?
What is the MOST likely long-term consequence of chronic duodeno-gastric reflux in the development of gastric ulcers?
What is the MOST likely long-term consequence of chronic duodeno-gastric reflux in the development of gastric ulcers?
A patient presents with symptoms of a peptic ulcer, and the physician suspects H. pylori infection. Which of the following tests allows for simultaneous detection of the bacteria and assessment of antibiotic sensitivity?
A patient presents with symptoms of a peptic ulcer, and the physician suspects H. pylori infection. Which of the following tests allows for simultaneous detection of the bacteria and assessment of antibiotic sensitivity?
While assessing a patient suspected of a peptic ulcer, which clinical finding would MOST strongly suggest a duodenal location over a gastric location?
While assessing a patient suspected of a peptic ulcer, which clinical finding would MOST strongly suggest a duodenal location over a gastric location?
A patient with chronic peptic ulcer disease develops a gastric outlet obstruction. Which of the following mechanisms MOST directly contributes to this obstruction?
A patient with chronic peptic ulcer disease develops a gastric outlet obstruction. Which of the following mechanisms MOST directly contributes to this obstruction?
According to the information provided, which of the following conditions constitutes Saint's triad?
According to the information provided, which of the following conditions constitutes Saint's triad?
Which of the following is the MOST critical factor in the pathogenesis of gastric ulcers associated with chronic ischaemia?
Which of the following is the MOST critical factor in the pathogenesis of gastric ulcers associated with chronic ischaemia?
What is the PRIMARY action of urease, an enzyme produced by Helicobacter pylori, that contributes to gastric mucosal damage?
What is the PRIMARY action of urease, an enzyme produced by Helicobacter pylori, that contributes to gastric mucosal damage?
A patient is diagnosed with a gastric ulcer. The ulcer is located in the antral part of the stomach. Which pathological process is MOST likely to initiate ulcer development in this region?
A patient is diagnosed with a gastric ulcer. The ulcer is located in the antral part of the stomach. Which pathological process is MOST likely to initiate ulcer development in this region?
A 30-year-old male presents with recurrent peptic ulcers despite eradication therapy for H. pylori. He has no history of NSAID use or smoking. Which of the following genetic predispositions would raise suspicion for Multiple Endocrine Neoplasia type 1 (MEN1) related Zollinger-Ellison syndrome?
A 30-year-old male presents with recurrent peptic ulcers despite eradication therapy for H. pylori. He has no history of NSAID use or smoking. Which of the following genetic predispositions would raise suspicion for Multiple Endocrine Neoplasia type 1 (MEN1) related Zollinger-Ellison syndrome?
A patient with a hx of peptic ulcer disease presents with epigastric pain that is exacerbated by eating but relieved with the use of antacids. Which clinical characteristic MOST strongly suggests that the ulcer is gastric rather than duodenal in origin?
A patient with a hx of peptic ulcer disease presents with epigastric pain that is exacerbated by eating but relieved with the use of antacids. Which clinical characteristic MOST strongly suggests that the ulcer is gastric rather than duodenal in origin?
A patient undergoing an endoscopy for a suspected peptic ulcer is found to have a large, deeply penetrating ulcer with significant surrounding inflammation. The gastroenterologist describes the surrounding mucosa as converging towards the ulcer. What specific characteristic of the ulcer is being described?
A patient undergoing an endoscopy for a suspected peptic ulcer is found to have a large, deeply penetrating ulcer with significant surrounding inflammation. The gastroenterologist describes the surrounding mucosa as converging towards the ulcer. What specific characteristic of the ulcer is being described?
Flashcards
Peptic Ulcer Definition
Peptic Ulcer Definition
Ulcer that is bathed in acid (HCL).
Peptic Ulcer Sites
Peptic Ulcer Sites
DU (Duodenal Ulcer), GU (Gastric Ulcer), Jejunum, Lower end esophagus, Terminal ileum
Drug-induced Ulcers
Drug-induced Ulcers
Steroids & NSAIDs.
Stress Ulcers
Stress Ulcers
Hypotension from Hemorrhage.
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Cushing's Ulcer
Cushing's Ulcer
After cerebral trauma.
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Curling's Ulcer
Curling's Ulcer
After major burns.
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Acute Peptic Ulcer Number
Acute Peptic Ulcer Number
Multiple
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Acute Peptic Ulcer Site
Acute Peptic Ulcer Site
Antrum of stomach more often than the duodenum.
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Acute Peptic Ulcer Characters
Acute Peptic Ulcer Characters
Superficial, rarely invading mucosa
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Peptic Ulcer Prophylaxis
Peptic Ulcer Prophylaxis
Avoid all predisposing causes.
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Prophylaxis for Peptic Ulcers
Prophylaxis for Peptic Ulcers
Avoid all predisposing causes.
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Curative Treatment of Peptic Ulcers
Curative Treatment of Peptic Ulcers
Essentially conservative.
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Gastric Ulcer Age
Gastric Ulcer Age
40-60 years
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Gender in Gastric Ulcers
Gender in Gastric Ulcers
Male and Female are equally affected
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Genetic Predisposition of Gastric Ulcers
Genetic Predisposition of Gastric Ulcers
More in -ve blood group
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Increasing Destruction of Gastric Mucosa
Increasing Destruction of Gastric Mucosa
Duodeno-gastric reflux, Antral stasis, Smoking, Trauma, Infection (H. pylori)
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Urease Enzyme
Urease Enzyme
H. pylori hydrolyzes urea to CO2 and ammonia.
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Decreasing Reconstruction of Gastric Mucosa
Decreasing Reconstruction of Gastric Mucosa
Ischaemic Theory, Malnutrition, Vitamin A & C Deficiency
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Duodenal Ulcer Etiology
Duodenal Ulcer Etiology
↑↑ parietal cell mass, ↑↑ vagal tone, ↑↑↑ gastrin hormone, ↑↑ Histamine, Trauma, Infection
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Increased Vagal Tone
Increased Vagal Tone
Tall, Thin and Tense individuals
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Duodenum site
Duodenum site
Duodenum is the commonest site
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Stomach site
Stomach site
Lesser curve (ulcer-bearing area) because of food trauma
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GI Bleeding
GI Bleeding
History of GI Bleeding
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Peptic Ulcer Investigation
Peptic Ulcer Investigation
Emergency fibre-optic gastroscopy.
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Peptic Ulcer Perforation
Peptic Ulcer Perforation
DUODENAL ULCER is more common
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DU location and Stenosis
DU location and Stenosis
gastric outlet obstruction
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GU location and Stenosis
GU location and Stenosis
Hour- Glass or Tea-pot stomach.
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GU Malignancy
GU Malignancy
GU may turn malignant less than 0.5%
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Peptic Ulcer Number
Peptic Ulcer Number
single, Multiple ulcers may occur in Z.E syndrome.
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Prevalence between genders for Duodenal Ulcers
Prevalence between genders for Duodenal Ulcers
Male to female: 3:1
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Genetic Predisposition Duodenal Ulcers
Genetic Predisposition Duodenal Ulcers
More in blood group O
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Zollinger-Ellison syndrome
Zollinger-Ellison syndrome
↑serum gastrin
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Hyperparathyroidism
Hyperparathyroidism
Hypercalcemia
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Liver cirrhosis
Liver cirrhosis
leads to lack of inactivation of gastrin and histamine.
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Peptic Ulcer Shape
Peptic Ulcer Shape
Rounded or oval but usually irregular due to fibrosis.
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Peptic Ulcer Edges
Peptic Ulcer Edges
Sloping or punched out.
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Peptic Ulcer Floor
Peptic Ulcer Floor
covered by easily bleeding granulation tissue.
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Peptic Ulcer Margin
Peptic Ulcer Margin
Surrounding mucosa converge on ulcer as a result of scarring
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Peptic Ulcer Base
Peptic Ulcer Base
deeply penetrating reaching to serosa and may perforates nearby organs.
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Pointing sign
Pointing sign
Patient can localize the point of maximum pain
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Resistant ulcers
Resistant ulcers
to treatment with H2 receptor blockers.
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Ulcers in unusual sites
Ulcers in unusual sites
as distal duodenum and proximal jejunum.
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Weight loss
Weight loss
Hematemesis > melena
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Weight loss
Weight loss
Melena > Hematemesis
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- An ulcer is bathed in acid (HCL)
Sites for Peptic Ulcers
- DU
- GU
- Jejunum: in ZES and gastrojejunostomy
- Lower end esophagus: in GERD
- Terminal ileum: in Meckel's diverticulum containing heterotopic gastric epithelium
Acute Peptic Ulcers
- Drug induced ulcers are caused by steroids and NSAIDs
- Stress Ulcers are caused by hypotension from hemorrhage
- Cushing's Ulcer happens after cerebral trauma
- Curling's Ulcer happens after major burns
Pathology of Acute Peptic Ulcers
- Multiple in numbers
- Located at ant part of the stomach, most often the duodenum
- Superficial in character rarely invading mucosa
Clinical Picture of Acute Peptic Ulcers
- Varies from mild dyspepsia to severe attack of haematemsis or perforation of the ulcer
Investigations of Acute Peptic Ulcers
- Emergency fibre-optic gastroscopy
Treatment of Acute Peptic Ulcers
- Prophylaxis: Avoid all predisposing causes
- Curative: Essentially conservative, conservative, interventional and finally surgery
Chronic Peptic Ulcer Etiology
Gastric Ulcer
- Age is most often 40-60 years
- Gender is more common in females
- Negative Family History
- More common in -ve blood group
Duodenal Ulcer
- Age is most often 20-40 years
- Gender is more common in males at a rate of 3:1
- Positive Family History
- More common in O blood group
Precipitating Factors
- Gastric Ulcer (Devitalization of Mucosa)
- Increasing Destruction of Gastric Mucosa due to Duodeno-gastric reflux (Cooper's theory)
- Increasing Destruction of Gastric Mucosa due to Antral stasis (Dragstedt theory)
- Increasing Destruction of Gastric Mucosa due to Smoking
- Increasing Destruction of Gastric Mucosa due to Trauma by irritant food includes spices, coffee, tea, alcohol and ulcerogenic drugs
- Increasing Destruction of Gastric Mucosa due to Infection by Helicobacter pylori: G-ve bacilli which is adherent to antral mucosa
- It produces substances that damage gastric and duodenal mucosa such as Urease enzyme, it hydrolyzes urea to CO2 & ammonia which is a strong alkali that damages the mucosa and Proteases enzyme, it degrades the protective mucus layer
Decreasing Reconstruction of Gastric Mucosa Due To:
- Ischaemic theory: a decrease in blood supply as in old atherosclerotic patients and IHD
- Malnutrition: Deficiency of proteins
- Deficiency of Vitamins A and C
II) Deuodenal Ulcer (Hyperacidity)
- ↑↑ parietal cell mass: (hyperplasia)
- ↑↑ vagal tone: as in Tall, Thin and Tense individuals
- ↑↑↑ gastrin hormone:
- Zollinger-Ellison's syndrome
- Hyperparathyroidism → Hypercalcemia which increase gastric acid secretion - Liver cirrhosis leads to the lack of inactivation of gastrin and histamine
- ↑↑ Histamine (Allergic theory): Ag/Ab reaction
- Trauma by irritant food, increases gastric acidity
- Infection by Helicobacter causes a decrease in secretion of pancreaticoduodenal bicarbonate
Pathology
- Number of ulcers is usually single; multiple can occur in Z.E Syndrome
- The most common site is the Duodenum: a Bulbar ulcer is in antero-superior aspect of 1st inch of 1st part of duodenum, it's the site of antral jets or Stomach a Lesser curve (ulcer-bearing area), because of food trauma and lesser curvature less vascular than greater curve
- Size is usually less than one inch (GU larger than D.U)
- Shape is Rounded or oval but usually irregular due to fibrosis
- Edges are Sloping or punched out
- Floor is covered by easily bleeding granulation tissue
- Base is deeply penetrating reaching to serosa and may perforates nearby organs
- Margin: Surrounding mucosa converge on ulcer as a result of scarring
Complications
- Bleeding which is more common in D.U. than G.U, haematemsis is commoner in GU or melena is commoner in D.U or Both
- Perforation which is more common in DU > GU
- Stenosis: GU is Hour- Glass or Tea-pot stomach or DU is Pyloric stenosis. (Gastric outlet obstruction)
- Malignancy where GU may turn malignant in less than 0.5% but never in DU
Clinical Picture
Gastric Ulcer
- Deep-seated burning pain located Epigastric to the left of the midline and has a Retrostenal heartburn radiation around half an hour to 1 hour after meals which is increased by Irritant foods, alcohol, smoking & stress but decreased by Vomiting
- Vomiting is Common, self-induced and has a tendency to occur during spring, winter & autumn periods of ulcer activity followed by freedom periods from 2-6 months where the patient is completely free
- Patient has Good appetite but is afraid to eat from pain resulting in Weight loss and Hematemesis > melena, caused by reflex inhibition of intestinal motility by pain OR pylorospasm
- Pointing sign is when a patient can localize the point of maximum pain
- Presence of Localized deep tenderness at that point Just to the left of midline
Duodenal Ulcer
- Deep-seated burning pain located Epigastric to the right of the midline and has around 2 hours after meals radiation, patients also have Hunger pain around 1/2-1 hour before next meal or pain that wakes the patient in midnight the pain is increased by Hunger but decreased by Alkalis & antacids or Eating small frequent meal
- Vomiting is Rare, except when pyloric stenosis occurred and has a tendency to occur during spring, winter & autumn periods of ulcer activity followed by freedom periods from 2-6 months where the patient is completely free
- Patient has Good appetite when patient eats frequent small meals, also has Over weight and Melena > Hematemesis, caused by reflex inhibition of intestinal motility by pain OR pylorospasm
- Pointing sign is when a patient can localize the point of maximum pain
- Presence of Localized deep tenderness at that point Just to the right of midline is caused by reflex inhibition of intestinal motility by pain OR pylorospasm
PU of ZES is suspected clinically by
- Resistant ulcers to treatment with H2 receptor blockers
- Recurrent ulcers
- Multiple ulcers
- Ulcers in unusual sites as distal duodenum and proximal jejunum
- Peptic ulcers at the extremes of age
- Peptic ulcers with a strong family history of ulcer disease of MEN syndrome
- Wilkie's Triad which is Chronic Cholecystitis + Peptic ulcer + Appendicitis
- Saint's triad is Chronic Cholecystitis + H.H. + Colonic diverticulosis
Investigations
- CBC: iron deficiency anemia due to chronic blood loss
- Stools: Occult blood is present (Benzedine test- Guaicum test)
- Estimation of serum gastrin (N up to 100 pg/ml) can be diagnostic if > 500 pg/ml for Z.E.S
- Gastric function tests: Hyperacidity in D.U. and Normal or hypoacidity in GU.
- Radiological investigations uses a Barium meal to visualize the ulcer
- Upper GIT Endoscopy + Biopsy uses a 4 or 8 quadrants biopsy from ulcer edge by endoscopy or Exfoliative Cytology done from gastric wash or Brush cytology
- Investigation to Detect H. Pylori uses a Urease test by applying Urea & reagent on the ulcer, if color is changed its helicobacter pylori, Serology is done by detection of specific antibodies or Culture is used in detection of organisms
Differential Diagnosis
- From other causes of dyspepsia & haematemsis
- Difference between benign & malignant ulcer
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