Podcast
Questions and Answers
Why is GSH essential for normal RBC structure?
Why is GSH essential for normal RBC structure?
What is the significance of CO2 produced from the pentose phosphate pathway?
What is the significance of CO2 produced from the pentose phosphate pathway?
Which of the following is a clinical manifestation of low levels of GSH?
Which of the following is a clinical manifestation of low levels of GSH?
Which factor strongly inhibits glucose 6-phosphate dehydrogenase (G6PD)?
Which factor strongly inhibits glucose 6-phosphate dehydrogenase (G6PD)?
Signup and view all the answers
What induces the synthesis of glucose 6-phosphate dehydrogenase after a high carbohydrate meal?
What induces the synthesis of glucose 6-phosphate dehydrogenase after a high carbohydrate meal?
Signup and view all the answers
What is the clinical significance of Glucose-6-phosphate dehydrogenase (G6PD) deficiency?
What is the clinical significance of Glucose-6-phosphate dehydrogenase (G6PD) deficiency?
Signup and view all the answers
Which pathway produces CO2 as a byproduct?
Which pathway produces CO2 as a byproduct?
Signup and view all the answers
Which of the following is an occurrence of the HMP pathway?
Which of the following is an occurrence of the HMP pathway?
Signup and view all the answers
Which pathway utilizes ATP as well as produces it?
Which pathway utilizes ATP as well as produces it?
Signup and view all the answers
What is the biological significance of the HMP pathway?
What is the biological significance of the HMP pathway?
Signup and view all the answers
In which form are intermediates found in the HMP pathway?
In which form are intermediates found in the HMP pathway?
Signup and view all the answers
What is the consequence of decreased G6PD activity in red blood cells?
What is the consequence of decreased G6PD activity in red blood cells?
Signup and view all the answers
Which triggers can lead to the development of acute hemolytic anemia in individuals with G6PD deficiency?
Which triggers can lead to the development of acute hemolytic anemia in individuals with G6PD deficiency?
Signup and view all the answers
What is the association between G6PD deficiency and malaria?
What is the association between G6PD deficiency and malaria?
Signup and view all the answers
Which coenzyme is required by the enzyme Transketolase during the non-oxidative phase?
Which coenzyme is required by the enzyme Transketolase during the non-oxidative phase?
Signup and view all the answers
What is the clinical significance of measuring R.B.C Transketolase activity?
What is the clinical significance of measuring R.B.C Transketolase activity?
Signup and view all the answers
In what condition is Wernicke's encephalopathy commonly seen?
In what condition is Wernicke's encephalopathy commonly seen?
Signup and view all the answers
What is the role of NADPH in preventing Met-Hemoglobinemia?
What is the role of NADPH in preventing Met-Hemoglobinemia?
Signup and view all the answers
Which function does reduced glutathione (GSH) serve in cells?
Which function does reduced glutathione (GSH) serve in cells?
Signup and view all the answers
What is the main mechanism by which glutathione protects cells against highly reactive oxygen derivatives?
What is the main mechanism by which glutathione protects cells against highly reactive oxygen derivatives?
Signup and view all the answers
In what way is NADPH involved in the process of protecting cells against ROS?
In what way is NADPH involved in the process of protecting cells against ROS?
Signup and view all the answers
What is the composition of Glutathione (GSH)?
What is the composition of Glutathione (GSH)?
Signup and view all the answers
What role does reduced glutathione (GSH) play in maintaining the normal reduced state of RBCs?
What role does reduced glutathione (GSH) play in maintaining the normal reduced state of RBCs?
Signup and view all the answers
What is the product of the oxidative non-reversible phase of the pentose phosphate pathway?
What is the product of the oxidative non-reversible phase of the pentose phosphate pathway?
Signup and view all the answers
Which enzyme is responsible for the transfer of the 2-C fragment during the HMP-Shunt pathway?
Which enzyme is responsible for the transfer of the 2-C fragment during the HMP-Shunt pathway?
Signup and view all the answers
What compound is converted back to Glucose 6-p in the non-oxidative reversible phase of the pentose phosphate pathway?
What compound is converted back to Glucose 6-p in the non-oxidative reversible phase of the pentose phosphate pathway?
Signup and view all the answers
Which molecule can enter the glycolytic pathway through the pentose pathway?
Which molecule can enter the glycolytic pathway through the pentose pathway?
Signup and view all the answers
What molecules are generated by the oxidative non-reversible phase of the pentose phosphate pathway?
What molecules are generated by the oxidative non-reversible phase of the pentose phosphate pathway?
Signup and view all the answers
Which enzyme is involved in dehydrogenation and decarboxylation during the first phase of the pentose phosphate pathway?
Which enzyme is involved in dehydrogenation and decarboxylation during the first phase of the pentose phosphate pathway?
Signup and view all the answers
