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Questions and Answers
What is the primary function of the Pentose Phosphate Pathway?
What is the primary function of the Pentose Phosphate Pathway?
Where does the PPP occur in the cell?
Where does the PPP occur in the cell?
How much glucose per day enters the PPP?
How much glucose per day enters the PPP?
What is the difference between the EM pathway and the PPP?
What is the difference between the EM pathway and the PPP?
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What is the product of the oxidative reactions of the PPP?
What is the product of the oxidative reactions of the PPP?
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What is the product of the non-oxidative reactions of the PPP?
What is the product of the non-oxidative reactions of the PPP?
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Which organs operate the oxidative reactions of the PPP?
Which organs operate the oxidative reactions of the PPP?
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Which cell types operate the non-oxidative reactions of the PPP?
Which cell types operate the non-oxidative reactions of the PPP?
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What is the physiological significance of the PPP?
What is the physiological significance of the PPP?
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What is G6PD deficiency?
What is G6PD deficiency?
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What is the precipitating factor for G6PD deficiency?
What is the precipitating factor for G6PD deficiency?
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What is the primary function of the Pentose Phosphate Pathway?
What is the primary function of the Pentose Phosphate Pathway?
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Where does the PPP occur in the cell?
Where does the PPP occur in the cell?
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How much glucose per day enters the PPP?
How much glucose per day enters the PPP?
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What is the difference between the EM pathway and the PPP?
What is the difference between the EM pathway and the PPP?
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What is the product of the oxidative reactions of the PPP?
What is the product of the oxidative reactions of the PPP?
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What is the product of the non-oxidative reactions of the PPP?
What is the product of the non-oxidative reactions of the PPP?
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Which organs operate the oxidative reactions of the PPP?
Which organs operate the oxidative reactions of the PPP?
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Which cell types operate the non-oxidative reactions of the PPP?
Which cell types operate the non-oxidative reactions of the PPP?
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What is the physiological significance of the PPP?
What is the physiological significance of the PPP?
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What is G6PD deficiency?
What is G6PD deficiency?
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What is the precipitating factor for G6PD deficiency?
What is the precipitating factor for G6PD deficiency?
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What is the primary purpose of the Pentose Phosphate Pathway (PPP)?
What is the primary purpose of the Pentose Phosphate Pathway (PPP)?
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Which of the following is not a difference between the Embden-Meyerhof (EM) pathway and the Pentose Phosphate Pathway (PPP)?
Which of the following is not a difference between the Embden-Meyerhof (EM) pathway and the Pentose Phosphate Pathway (PPP)?
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What is the product of the oxidative reactions of the PPP?
What is the product of the oxidative reactions of the PPP?
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Which of the following organs does not operate the oxidative reactions of the PPP?
Which of the following organs does not operate the oxidative reactions of the PPP?
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What is the clinical significance of glucose 6-phosphate dehydrogenase (G6PD) deficiency?
What is the clinical significance of glucose 6-phosphate dehydrogenase (G6PD) deficiency?
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What is the difference between the oxidative and non-oxidative reactions of the PPP?
What is the difference between the oxidative and non-oxidative reactions of the PPP?
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What is the function of NADPH produced by the PPP?
What is the function of NADPH produced by the PPP?
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Which of the following is not a physiological significance of the PPP?
Which of the following is not a physiological significance of the PPP?
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What is the difference between the hydrogen acceptors of the EM pathway and the PPP?
What is the difference between the hydrogen acceptors of the EM pathway and the PPP?
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What is the difference between the PPP and the EM pathway in terms of CO2 production?
What is the difference between the PPP and the EM pathway in terms of CO2 production?
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What is the main function of the non-oxidative reactions of the PPP?
What is the main function of the non-oxidative reactions of the PPP?
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What is the significance of the PPP in erythrocytes?
What is the significance of the PPP in erythrocytes?
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What is the major purpose of the Pentose Phosphate Pathway?
What is the major purpose of the Pentose Phosphate Pathway?
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Which part of the cell does the Pentose Phosphate Pathway occur in?
Which part of the cell does the Pentose Phosphate Pathway occur in?
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How much glucose per day enters the Pentose Phosphate Pathway?
How much glucose per day enters the Pentose Phosphate Pathway?
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What is the difference between the Pentose Phosphate Pathway and the Embden-Meyerhof (EM) pathway?
What is the difference between the Pentose Phosphate Pathway and the Embden-Meyerhof (EM) pathway?
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What is produced by the oxidative reactions of the Pentose Phosphate Pathway?
What is produced by the oxidative reactions of the Pentose Phosphate Pathway?
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What is produced by the non-oxidative reactions of the Pentose Phosphate Pathway?
What is produced by the non-oxidative reactions of the Pentose Phosphate Pathway?
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In which organs do the oxidative reactions of the Pentose Phosphate Pathway operate?
In which organs do the oxidative reactions of the Pentose Phosphate Pathway operate?
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In which cell types do the non-oxidative reactions of the Pentose Phosphate Pathway operate?
In which cell types do the non-oxidative reactions of the Pentose Phosphate Pathway operate?
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What is the physiological significance of the Pentose Phosphate Pathway?
What is the physiological significance of the Pentose Phosphate Pathway?
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What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
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What are the symptoms of G6PD deficiency?
What are the symptoms of G6PD deficiency?
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What are the precipitating factors for G6PD deficiency?
What are the precipitating factors for G6PD deficiency?
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What is the major purpose of the Pentose Phosphate Pathway?
What is the major purpose of the Pentose Phosphate Pathway?
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Which pathway occurs in all tissues?
Which pathway occurs in all tissues?
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What is the hydrogen acceptor in the oxidative reactions of the Pentose Phosphate Pathway?
What is the hydrogen acceptor in the oxidative reactions of the Pentose Phosphate Pathway?
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Which pathway requires and produces ATP?
Which pathway requires and produces ATP?
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What is the main function of the non-oxidative reactions of the Pentose Phosphate Pathway?
What is the main function of the non-oxidative reactions of the Pentose Phosphate Pathway?
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Which organs operate the oxidative reactions of the Pentose Phosphate Pathway?
Which organs operate the oxidative reactions of the Pentose Phosphate Pathway?
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What is the clinical significance of glucose 6-phosphate dehydrogenase (G6PD) deficiency?
What is the clinical significance of glucose 6-phosphate dehydrogenase (G6PD) deficiency?
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What is the most severe effect of G6PD deficiency?
What is the most severe effect of G6PD deficiency?
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What is the cause of G6PD deficiency?
What is the cause of G6PD deficiency?
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What is the primary function of the PPP?
What is the primary function of the PPP?
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Which pathway involves oxidation by dehydrogenation with NAD as the hydrogen acceptor?
Which pathway involves oxidation by dehydrogenation with NAD as the hydrogen acceptor?
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What is the primary function of the oxidative reactions of the PPP?
What is the primary function of the oxidative reactions of the PPP?
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What is the alternative pathway for glucose oxidation known as?
What is the alternative pathway for glucose oxidation known as?
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What is the major purpose of the PPP?
What is the major purpose of the PPP?
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Where does the PPP occur in the cell?
Where does the PPP occur in the cell?
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How much glucose per day enters the PPP?
How much glucose per day enters the PPP?
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What are the products of the PPP?
What are the products of the PPP?
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What is the major difference between the EM pathway and the PPP?
What is the major difference between the EM pathway and the PPP?
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What is required and produced in the EM pathway?
What is required and produced in the EM pathway?
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What is required but not produced in the PPP?
What is required but not produced in the PPP?
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Where do the oxidative reactions of the PPP operate?
Where do the oxidative reactions of the PPP operate?
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Where do the non-oxidative reactions of the PPP operate?
Where do the non-oxidative reactions of the PPP operate?
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What is the physiological significance of the PPP?
What is the physiological significance of the PPP?
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What is the most common enzyme deficiency seen in clinical practice?
What is the most common enzyme deficiency seen in clinical practice?
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What is the Pentose Phosphate Pathway (PPP)?
What is the Pentose Phosphate Pathway (PPP)?
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Where does the PPP occur?
Where does the PPP occur?
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What is the major purpose of the PPP?
What is the major purpose of the PPP?
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How many molecules of glucose-6-phosphate enter the PPP cycle?
How many molecules of glucose-6-phosphate enter the PPP cycle?
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What is the major difference between the PPP and the Embden-Meyerhof (EM) pathway?
What is the major difference between the PPP and the Embden-Meyerhof (EM) pathway?
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What is the hydrogen acceptor in the oxidative reactions of the PPP?
What is the hydrogen acceptor in the oxidative reactions of the PPP?
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Is ATP produced in the PPP?
Is ATP produced in the PPP?
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Is CO2 produced in the EM pathway?
Is CO2 produced in the EM pathway?
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What is the physiological significance of the PPP?
What is the physiological significance of the PPP?
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What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
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What is the most severe effect of G6PD deficiency?
What is the most severe effect of G6PD deficiency?
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What are the precipitating factors for G6PD deficiency?
What are the precipitating factors for G6PD deficiency?
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What is the other name for the Pentose Phosphate Pathway?
What is the other name for the Pentose Phosphate Pathway?
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Where does the Pentose Phosphate Pathway occur in the cell?
Where does the Pentose Phosphate Pathway occur in the cell?
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What is the major purpose of the Pentose Phosphate Pathway?
What is the major purpose of the Pentose Phosphate Pathway?
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Which of the following is not a product of the Pentose Phosphate Pathway?
Which of the following is not a product of the Pentose Phosphate Pathway?
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What are the major differences between the Embden-Meyerhof (EM) pathway and the PPP?
What are the major differences between the Embden-Meyerhof (EM) pathway and the PPP?
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Which organs operate the oxidative reactions of the PPP?
Which organs operate the oxidative reactions of the PPP?
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What is the physiological significance of the PPP?
What is the physiological significance of the PPP?
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What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
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What is the most severe effect of G6PD deficiency?
What is the most severe effect of G6PD deficiency?
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What is the role of the PPP in erythrocytes in individuals with G6PD deficiency?
What is the role of the PPP in erythrocytes in individuals with G6PD deficiency?
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What are the precipitating factors for G6PD deficiency?
What are the precipitating factors for G6PD deficiency?
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What is the role of the PPP in nucleotide synthesis?
What is the role of the PPP in nucleotide synthesis?
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What is the main purpose of the Pentose Phosphate Pathway?
What is the main purpose of the Pentose Phosphate Pathway?
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Where does the Pentose Phosphate Pathway occur?
Where does the Pentose Phosphate Pathway occur?
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How much glucose per day enters the Pentose Phosphate Pathway?
How much glucose per day enters the Pentose Phosphate Pathway?
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What are the major differences between the Embden-Meyerhof (EM) pathway and the PPP?
What are the major differences between the Embden-Meyerhof (EM) pathway and the PPP?
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What is the role of the oxidative reactions of the PPP?
What is the role of the oxidative reactions of the PPP?
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What is the role of the non-oxidative reactions of the PPP?
What is the role of the non-oxidative reactions of the PPP?
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What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
What is glucose 6-phosphate dehydrogenase (G6PD) deficiency?
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What are the precipitating factors for G6PD deficiency?
What are the precipitating factors for G6PD deficiency?
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What is the clinical significance of the PPP?
What is the clinical significance of the PPP?
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What is the role of NADPH in the PPP?
What is the role of NADPH in the PPP?
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Which tissues does the PPP operate in?
Which tissues does the PPP operate in?
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What is the difference between the hydrogen acceptors used in the PPP and the EM pathway?
What is the difference between the hydrogen acceptors used in the PPP and the EM pathway?
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Study Notes
The Pentose Phosphate Pathway: Definition, Differences from EM Pathway, Reactions, Physiological and Clinical Significance
- The Pentose Phosphate Pathway (PPP) is an alternative pathway for glucose oxidation, also known as the hexose monophosphate shunt or pentose phosphate pathway.
- The PPP occurs in the cytosol of the cell and about 10% of glucose per day enters this pathway.
- The major purposes of the PPP are the production of reduced nicotinamide adenine dinucleotide phosphate (NADPH) for use as a biochemical reductant, and the production of pentose phosphate for nucleotide synthesis.
- The PPP involves oxidative and non-oxidative reactions, with three molecules of glucose-6-phosphate entering the cycle and producing three molecules of CO2 and three molecules of 5 carbon residues, which give two molecules of glucose-6-phosphate and one molecule of glyceraldehyde-3-phosphate.
- The major differences between the Embden-Meyerhof (EM) pathway and the PPP include the fact that the EM pathway occurs in all tissues, while the PPP occurs in certain special tissues for a specific function.
- The PPP involves oxidation by dehydrogenation with NADP as the hydrogen acceptor, while the EM pathway involves oxidation by dehydrogenation with NAD as the hydrogen acceptor.
- ATP is required and produced in the EM pathway, while ATP is required but not produced in the PPP.
- CO2 is never formed in the EM pathway, while CO2 is produced in the PPP.
- The oxidative reactions of the PPP operate in organs such as the liver, lactating mammary glands, adipose, adrenal cortex, erythrocytes, testes and ovaries, and the lens of the eyes.
- The non-oxidative reactions of the PPP operate in all cell types synthesizing nucleotides and nucleic acids.
- The physiological significance of the PPP includes the generation of reducing equivalents for reductive biosynthesis of fatty acid, cholesterol, and steroids, free radical scavenging, erythrocyte membrane integrity, prevention of methemoglobinemia, preservation of the transparency of the lens of the eye, and macrophage bacteria activity.
- The clinical significance of the PPP includes glucose 6-phosphate dehydrogenase (G6PD) deficiency, which is the most common enzyme deficiency seen in clinical practice, and leads to hemolytic anemia characterized by anemia, jaundice, and black urine. G6PD deficiency occurs in all cells of the affected individual, but is most severe in erythrocytes, where the PPP provides the only means of generating NADPH. Precipitating factors for G6PD deficiency include treatment with oxidant drugs, ingesting fava beans (favism), and severe infection.
The Pentose Phosphate Pathway: Definition, Differences from EM Pathway, Reactions, Physiological and Clinical Significance
- The Pentose Phosphate Pathway (PPP) is an alternative pathway for glucose oxidation, also known as the hexose monophosphate shunt or pentose phosphate pathway.
- The PPP occurs in the cytosol of the cell and about 10% of glucose per day enters this pathway.
- The major purposes of the PPP are the production of reduced nicotinamide adenine dinucleotide phosphate (NADPH) for use as a biochemical reductant, and the production of pentose phosphate for nucleotide synthesis.
- The PPP involves oxidative and non-oxidative reactions, with three molecules of glucose-6-phosphate entering the cycle and producing three molecules of CO2 and three molecules of 5 carbon residues, which give two molecules of glucose-6-phosphate and one molecule of glyceraldehyde-3-phosphate.
- The major differences between the Embden-Meyerhof (EM) pathway and the PPP include the fact that the EM pathway occurs in all tissues, while the PPP occurs in certain special tissues for a specific function.
- The PPP involves oxidation by dehydrogenation with NADP as the hydrogen acceptor, while the EM pathway involves oxidation by dehydrogenation with NAD as the hydrogen acceptor.
- ATP is required and produced in the EM pathway, while ATP is required but not produced in the PPP.
- CO2 is never formed in the EM pathway, while CO2 is produced in the PPP.
- The oxidative reactions of the PPP operate in organs such as the liver, lactating mammary glands, adipose, adrenal cortex, erythrocytes, testes and ovaries, and the lens of the eyes.
- The non-oxidative reactions of the PPP operate in all cell types synthesizing nucleotides and nucleic acids.
- The physiological significance of the PPP includes the generation of reducing equivalents for reductive biosynthesis of fatty acid, cholesterol, and steroids, free radical scavenging, erythrocyte membrane integrity, prevention of methemoglobinemia, preservation of the transparency of the lens of the eye, and macrophage bacteria activity.
- The clinical significance of the PPP includes glucose 6-phosphate dehydrogenase (G6PD) deficiency, which is the most common enzyme deficiency seen in clinical practice, and leads to hemolytic anemia characterized by anemia, jaundice, and black urine. G6PD deficiency occurs in all cells of the affected individual, but is most severe in erythrocytes, where the PPP provides the only means of generating NADPH. Precipitating factors for G6PD deficiency include treatment with oxidant drugs, ingesting fava beans (favism), and severe infection.
The Pentose Phosphate Pathway: Definition, Differences from EM Pathway, Reactions, Physiological and Clinical Significance
- The Pentose Phosphate Pathway (PPP) is an alternative pathway for glucose oxidation, also known as the hexose monophosphate shunt or pentose phosphate pathway.
- The PPP occurs in the cytosol of the cell and about 10% of glucose per day enters this pathway.
- The major purposes of the PPP are the production of reduced nicotinamide adenine dinucleotide phosphate (NADPH) for use as a biochemical reductant, and the production of pentose phosphate for nucleotide synthesis.
- The PPP involves oxidative and non-oxidative reactions, with three molecules of glucose-6-phosphate entering the cycle and producing three molecules of CO2 and three molecules of 5 carbon residues, which give two molecules of glucose-6-phosphate and one molecule of glyceraldehyde-3-phosphate.
- The major differences between the Embden-Meyerhof (EM) pathway and the PPP include the fact that the EM pathway occurs in all tissues, while the PPP occurs in certain special tissues for a specific function.
- The PPP involves oxidation by dehydrogenation with NADP as the hydrogen acceptor, while the EM pathway involves oxidation by dehydrogenation with NAD as the hydrogen acceptor.
- ATP is required and produced in the EM pathway, while ATP is required but not produced in the PPP.
- CO2 is never formed in the EM pathway, while CO2 is produced in the PPP.
- The oxidative reactions of the PPP operate in organs such as the liver, lactating mammary glands, adipose, adrenal cortex, erythrocytes, testes and ovaries, and the lens of the eyes.
- The non-oxidative reactions of the PPP operate in all cell types synthesizing nucleotides and nucleic acids.
- The physiological significance of the PPP includes the generation of reducing equivalents for reductive biosynthesis of fatty acid, cholesterol, and steroids, free radical scavenging, erythrocyte membrane integrity, prevention of methemoglobinemia, preservation of the transparency of the lens of the eye, and macrophage bacteria activity.
- The clinical significance of the PPP includes glucose 6-phosphate dehydrogenase (G6PD) deficiency, which is the most common enzyme deficiency seen in clinical practice, and leads to hemolytic anemia characterized by anemia, jaundice, and black urine. G6PD deficiency occurs in all cells of the affected individual, but is most severe in erythrocytes, where the PPP provides the only means of generating NADPH. Precipitating factors for G6PD deficiency include treatment with oxidant drugs, ingesting fava beans (favism), and severe infection.
The Pentose Phosphate Pathway: Definition, Differences from EM Pathway, Reactions, Physiological and Clinical Significance
- The Pentose Phosphate Pathway (PPP) is an alternative pathway for glucose oxidation, also known as the hexose monophosphate shunt or pentose phosphate pathway.
- The PPP occurs in the cytosol of the cell and about 10% of glucose per day enters this pathway.
- The major purposes of the PPP are the production of reduced nicotinamide adenine dinucleotide phosphate (NADPH) for use as a biochemical reductant, and the production of pentose phosphate for nucleotide synthesis.
- The PPP involves oxidative and non-oxidative reactions, with three molecules of glucose-6-phosphate entering the cycle and producing three molecules of CO2 and three molecules of 5 carbon residues, which give two molecules of glucose-6-phosphate and one molecule of glyceraldehyde-3-phosphate.
- The major differences between the Embden-Meyerhof (EM) pathway and the PPP include the fact that the EM pathway occurs in all tissues, while the PPP occurs in certain special tissues for a specific function.
- The PPP involves oxidation by dehydrogenation with NADP as the hydrogen acceptor, while the EM pathway involves oxidation by dehydrogenation with NAD as the hydrogen acceptor.
- ATP is required and produced in the EM pathway, while ATP is required but not produced in the PPP.
- CO2 is never formed in the EM pathway, while CO2 is produced in the PPP.
- The oxidative reactions of the PPP operate in organs such as the liver, lactating mammary glands, adipose, adrenal cortex, erythrocytes, testes and ovaries, and the lens of the eyes.
- The non-oxidative reactions of the PPP operate in all cell types synthesizing nucleotides and nucleic acids.
- The physiological significance of the PPP includes the generation of reducing equivalents for reductive biosynthesis of fatty acid, cholesterol, and steroids, free radical scavenging, erythrocyte membrane integrity, prevention of methemoglobinemia, preservation of the transparency of the lens of the eye, and macrophage bacteria activity.
- The clinical significance of the PPP includes glucose 6-phosphate dehydrogenase (G6PD) deficiency, which is the most common enzyme deficiency seen in clinical practice, and leads to hemolytic anemia characterized by anemia, jaundice, and black urine. G6PD deficiency occurs in all cells of the affected individual, but is most severe in erythrocytes, where the PPP provides the only means of generating NADPH. Precipitating factors for G6PD deficiency include treatment with oxidant drugs, ingesting fava beans (favism), and severe infection.
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Test your knowledge on the Pentose Phosphate Pathway (PPP) with this informative quiz! Discover the differences between the PPP and the Embden-Meyerhof pathway, the reactions involved, and the physiological and clinical significance of the PPP. Challenge yourself with questions on glucose oxidation, NADPH production, and nucleotide synthesis. See how well you understand the role of the PPP in fatty acid and cholesterol biosynthesis, erythrocyte membrane integrity, and free radical scavenging. Don't