Podcast
Questions and Answers
What is a benefit of PEGylation on enzymes?
What is a benefit of PEGylation on enzymes?
- Reduces the half-life
- Increases immunogenicity
- Reduces immunogenicity and increases the half-life (correct)
- Has no effect on immunogenicity or half-life
What is an advantage of using PEGylated enzymes in therapy?
What is an advantage of using PEGylated enzymes in therapy?
- They are less effective than non-PEGylated enzymes
- They are more likely to cause an immune response
- They are more expensive to produce
- They have a longer half-life in the body (correct)
What is an example of an enzyme that can be PEGylated?
What is an example of an enzyme that can be PEGylated?
- L-glutamine
- Glucose oxidase
- L-asparaginase (correct)
- Adenosine triphosphate
Why is PEGylation used to modify enzymes?
Why is PEGylation used to modify enzymes?
What is the effect of PEGylation on the body's immune response to an enzyme?
What is the effect of PEGylation on the body's immune response to an enzyme?
What is a disadvantage of ERT challenges?
What is a disadvantage of ERT challenges?
Which of the following is NOT an advantage of ERT challenges?
Which of the following is NOT an advantage of ERT challenges?
What is a financial disadvantage of ERT challenges?
What is a financial disadvantage of ERT challenges?
What is a non-curative aspect of ERT challenges?
What is a non-curative aspect of ERT challenges?
What is an invasive aspect of ERT challenges?
What is an invasive aspect of ERT challenges?
Study Notes
ERT Challenges
- Inconvenient administration methods: IV or IM injections required
- More invasive treatment approach
- Limited effectiveness due to waning of effect over time
- Non-curative treatment option
- High cost: $$$
Advantages of ERT
- Fewer side effects experienced by patients
- Longer history of drug use, establishing safety and efficacy
- Wider availability for use in diverse patient populations
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Description
This quiz covers the process of PEGylation in improving enzymes, reducing immunogenicity and increasing half-life. Learn about examples such as adenosine deaminase and L-asparaginase.
