10 Questions
What is a benefit of PEGylation on enzymes?
Reduces immunogenicity and increases the half-life
What is an advantage of using PEGylated enzymes in therapy?
They have a longer half-life in the body
What is an example of an enzyme that can be PEGylated?
L-asparaginase
Why is PEGylation used to modify enzymes?
To reduce their immunogenicity and increase their half-life
What is the effect of PEGylation on the body's immune response to an enzyme?
It reduces the immune response
What is a disadvantage of ERT challenges?
Waning of effect
Which of the following is NOT an advantage of ERT challenges?
Waning of effect
What is a financial disadvantage of ERT challenges?
Expensive
What is a non-curative aspect of ERT challenges?
Not curative
What is an invasive aspect of ERT challenges?
More invasive
Study Notes
ERT Challenges
- Inconvenient administration methods: IV or IM injections required
- More invasive treatment approach
- Limited effectiveness due to waning of effect over time
- Non-curative treatment option
- High cost: $$$
Advantages of ERT
- Fewer side effects experienced by patients
- Longer history of drug use, establishing safety and efficacy
- Wider availability for use in diverse patient populations
This quiz covers the process of PEGylation in improving enzymes, reducing immunogenicity and increasing half-life. Learn about examples such as adenosine deaminase and L-asparaginase.
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