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PEGylation of Enzymes in Biotechnology

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Questions and Answers

What is a benefit of PEGylation on enzymes?

Reduces the half-life

Increases immunogenicity

Reduces immunogenicity and increases the half-life (correct)

Has no effect on immunogenicity or half-life

What is an advantage of using PEGylated enzymes in therapy?

They are less effective than non-PEGylated enzymes

They are more likely to cause an immune response

They are more expensive to produce

They have a longer half-life in the body (correct)

What is an example of an enzyme that can be PEGylated?

L-glutamine

Glucose oxidase

L-asparaginase (correct)

Adenosine triphosphate

Why is PEGylation used to modify enzymes?

To reduce their immunogenicity and increase their half-life Signup and view all the answers

What is the effect of PEGylation on the body's immune response to an enzyme?

It reduces the immune response Signup and view all the answers

What is a disadvantage of ERT challenges?

Waning of effect Signup and view all the answers

Which of the following is NOT an advantage of ERT challenges?

Waning of effect Signup and view all the answers

What is a financial disadvantage of ERT challenges?

Expensive Signup and view all the answers

What is a non-curative aspect of ERT challenges?

Not curative Signup and view all the answers

What is an invasive aspect of ERT challenges?

More invasive Signup and view all the answers

Study Notes

ERT Challenges

Inconvenient administration methods: IV or IM injections required
More invasive treatment approach
Limited effectiveness due to waning of effect over time
Non-curative treatment option
High cost: $$$

Advantages of ERT

Fewer side effects experienced by patients
Longer history of drug use, establishing safety and efficacy
Wider availability for use in diverse patient populations

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Description

This quiz covers the process of PEGylation in improving enzymes, reducing immunogenicity and increasing half-life. Learn about examples such as adenosine deaminase and L-asparaginase.