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Questions and Answers
How does absorption in pediatric patients differ from adults?
How does absorption in pediatric patients differ from adults?
- The gastric pH in pediatric patients is less acidic until 1-2 years of age (correct)
- The first-pass elimination in pediatric patients is more efficient than in adults
- The gastric emptying in pediatric patients is faster than in adults
- The intramuscular absorption in pediatric patients is slower and regular
What factor affects drug distribution in pediatric patients?
What factor affects drug distribution in pediatric patients?
- Mature blood-brain barrier
- Increased level of protein binding
- Lower fat content (correct)
- High fat content
Why might pediatric patients experience more side effects from drugs?
Why might pediatric patients experience more side effects from drugs?
- Decreased metabolism in pediatric patients
- Immature blood-brain barrier allowing more drugs to enter the brain (correct)
- Greater protein binding in pediatric patients
- Lack of drug receptors in pediatric patients
What causes altered metabolism in pediatric patients?
What causes altered metabolism in pediatric patients?
How does kidney immaturity affect drug excretion in pediatric patients?
How does kidney immaturity affect drug excretion in pediatric patients?
Which factor affects pediatric drug doses according to the text?
Which factor affects pediatric drug doses according to the text?
What equipment preparation step is recommended when working with pediatric patients?
What equipment preparation step is recommended when working with pediatric patients?
What is one effect of pediatric patients having immature liver function?
What is one effect of pediatric patients having immature liver function?
What is one effect of pediatric patients having a slowed gastric emptying?
What is one effect of pediatric patients having a slowed gastric emptying?
In pediatric patients, what is faster and irregular?
In pediatric patients, what is faster and irregular?
What occurs with advancing age?
What occurs with advancing age?
Why might older children require higher doses of medication?
Why might older children require higher doses of medication?
Lifespan considerations have dramatic effects on the four phases of
Lifespan considerations have dramatic effects on the four phases of
With pediatric patients, what do we assess before, during, and after drug administration?
With pediatric patients, what do we assess before, during, and after drug administration?
Match
Match
Older adult patients metabolism is altered due to aging liver and reduced blood flow to the liver.
Older adult patients metabolism is altered due to aging liver and reduced blood flow to the liver.
Study Notes
Pediatric Pharmacology
- Absorption in pediatric patients differs from adults due to differences in gastric pH, gastric emptying, and gastrointestinal motility.
Drug Distribution
- Body composition and fluid distribution affect drug distribution in pediatric patients.
Adverse Effects
- Pediatric patients may experience more side effects from drugs due to differences in pharmacokinetics and pharmacodynamics.
Metabolism
- Altered metabolism in pediatric patients is caused by immature liver function, which affects enzyme systems responsible for drug metabolism.
Excretion
- Kidney immaturity in pediatric patients affects drug excretion, as the glomerular filtration rate and tubular secretion are not fully developed.
Dosing
- Pediatric drug doses are affected by the patient's weight, which is used to calculate dosages.
Equipment Preparation
- When working with pediatric patients, it is recommended to have equipment prepared in advance, such as syringes and infusion pumps, to ensure accurate dosing.
Liver Function
- Immature liver function in pediatric patients can lead to reduced drug metabolism.
Gastric Emptying
- Slowed gastric emptying in pediatric patients can lead to delayed drug absorption.
Heart Rate
- Pediatric patients have a faster and irregular heart rate.
Age-Related Changes
- With advancing age, pediatric patients' heart rate and metabolism slow down.
Dosing in Older Children
- Older children may require higher doses of medication due to their increased body size and weight.
Lifespan Considerations
- Lifespan considerations have dramatic effects on the four phases of pharmacokinetics: absorption, distribution, metabolism, and excretion.
Assessment
- Before, during, and after drug administration, we assess pediatric patients' vital signs, medical history, and medications to ensure safe and effective treatment.
Older Adults
- Older adult patients' metabolism is altered due to aging liver and reduced blood flow to the liver.
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Description
Test your knowledge of the effects of pediatric patients' lifespan considerations on the absorption and distribution phases of pharmacokinetics. Explore how gastric pH, gastric emptying, liver maturation, and intramuscular absorption impact drug absorption and distribution in pediatric patients.
