Pediatric Dosage Forms & Compliance
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Questions and Answers

Why is it important to shake suspensions before administration?

  • To ensure the drug molecules are dissolved properly.
  • To distribute undissolved drug particles throughout the vehicle. (correct)
  • To decrease the risk of adverse effects.
  • To reduce the risk of measuring errors.

    • What is the main difference between elixirs and suspensions?

  • Elixirs have a higher risk of toxicity than suspensions.
  • Elixirs are alcoholic solutions, while suspensions contain undissolved particles of drug. (correct)
  • Elixirs must be distributed throughout the vehicle, while suspensions are evenly distributed.
  • Elixirs require shaking, while suspensions do not.

    • What potential issues can arise if a suspension is not shaken well before each dose?

  • Increased efficacy of the drug
  • Decreased risk of spilling or measuring errors
  • Early inefficacy or unexpected toxicity (correct)
  • Reduced plasma concentration at the end of therapy

    • What is the main focus of the article by Hansten and Horn?

    <p>Drug interactions in pediatric patients</p> Signup and view all the answers

    Why can compliance be more challenging in pediatric practice when it comes to administering medications?

    <p>Measuring errors and spitting out medication are common in children.</p> Signup and view all the answers

    How would the drug dosage for a 9-year-old child compare to the adult dose according to the text?

    <p>It would be 80% of the adult dose.</p> Signup and view all the answers

    Which publication emphasizes the importance of counseling women on drug exposure during the first trimester?

    <p>Koren G, Pastuszak A</p> Signup and view all the answers

    Based on Clark's rule, how is the pediatric drug dosage calculated in relation to an adult dose?

    <p>The pediatric dose is calculated based on the child's weight compared to 70 kg.</p> Signup and view all the answers

    Why is it important to conduct studies in children to determine safe and effective drug doses?

    <p>To establish proper dosages specific to children's age and condition.</p> Signup and view all the answers

    Which source provides information on the role of protease inhibitor therapy in children with HIV infection?

    <p>Gavin PJ, Yogev R</p> Signup and view all the answers

    In what area does Ito's research mainly contribute to?

    <p>Fetal drug therapy</p> Signup and view all the answers

    If an adult dosage is 2 mg/kg, what would be the approximate dosage for a 1-year-old according to the text?

    <p>1.2 mg/kg</p> Signup and view all the answers

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