PCOS First-Line Pharmacotherapy Options
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Questions and Answers

What is a potential benefit of using insulin sensitizers for women with PCOS?

  • Increased androgen levels and hirsutism
  • Enhanced menstrual cyclicity and acne
  • Improved glucose metabolism and lipid profiles (correct)
  • Promotion of atherosclerosis and type 2 diabetes

Why might metformin be prescribed to women with PCOS before an insulin sensitizer?

  • To induce hirsutism and acne
  • To manage glucose metabolism and prevent weight gain (correct)
  • To increase androgen levels and insulin resistance
  • To regulate menstrual cycles and reduce circulating androgens

What role do oral contraceptives typically play in the treatment of women with PCOS?

  • Exacerbate insulin resistance and glucose metabolism
  • Promote atherosclerosis and type 2 diabetes
  • Increase hirsutism, acne, and weight gain
  • Regulate menstrual cycle, reduce circulating androgens, improve mood (correct)

Why should the decision to use metformin for women with PCOS often be patient-driven?

<p>If the woman is overweight and has evidence of insulin resistance (A)</p> Signup and view all the answers

Which option correctly describes the long-term effects of oral contraceptives on glucose and lipid metabolism for women with PCOS?

<p>They have not been fully elucidated (B)</p> Signup and view all the answers

What should be the primary factor in deciding the first-line pharmacotherapy for women with PCOS?

<p>Relief from menstrual irregularity, hirsutism, or acne (A)</p> Signup and view all the answers

What is a common treatment for women with polycystic ovary syndrome (PCOS) who do not desire pregnancy?

<p>Oral contraceptives (A)</p> Signup and view all the answers

Which hormone, along with synthetic progestins, is generally effective and safe for most non-diabetic patients with PCOS?

<p>Estradiol (A)</p> Signup and view all the answers

What is a potential adverse effect of oral contraceptive (OC) use in women with PCOS?

<p>Worsened carbohydrate metabolism (B)</p> Signup and view all the answers

Which anti-androgen has been shown to reduce facial terminal hair growth in women with PCOS but its effects have not been proven permanent?

<p>Cyproterone acetate (C)</p> Signup and view all the answers

Which anti-androgen is not widely used due to the risks of hepatotoxicity?

<p>Flutamide (A)</p> Signup and view all the answers

Insulin resistance in PCOS patients can lead to an increased risk of what condition?

<p>Heart disease and stroke (D)</p> Signup and view all the answers

What is the key factor in the development of Polycystic Ovary Syndrome (PCOS) related to insulin resistance?

<p>'Normal' glucose response to insulin (B)</p> Signup and view all the answers

High insulin levels in PCOS patients can increase the production of what hormones?

<p>Insulin-like growth factors (A)</p> Signup and view all the answers

Which medication has been shown to improve hyperandrogenic symptoms and lower testosterone concentrations in women with PCOS?

<p>'Spironolactone' (D)</p> Signup and view all the answers

What is a potential concern that may limit the use of Cyproterone acetate in PCOS treatment?

<p>Hepatotoxicity risks (A)</p> Signup and view all the answers

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