PCOS First-Line Pharmacotherapy Options
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Questions and Answers

What is a potential benefit of using insulin sensitizers for women with PCOS?

  • Increased androgen levels and hirsutism
  • Enhanced menstrual cyclicity and acne
  • Improved glucose metabolism and lipid profiles (correct)
  • Promotion of atherosclerosis and type 2 diabetes
  • Why might metformin be prescribed to women with PCOS before an insulin sensitizer?

  • To induce hirsutism and acne
  • To manage glucose metabolism and prevent weight gain (correct)
  • To increase androgen levels and insulin resistance
  • To regulate menstrual cycles and reduce circulating androgens
  • What role do oral contraceptives typically play in the treatment of women with PCOS?

  • Exacerbate insulin resistance and glucose metabolism
  • Promote atherosclerosis and type 2 diabetes
  • Increase hirsutism, acne, and weight gain
  • Regulate menstrual cycle, reduce circulating androgens, improve mood (correct)
  • Why should the decision to use metformin for women with PCOS often be patient-driven?

    <p>If the woman is overweight and has evidence of insulin resistance</p> Signup and view all the answers

    Which option correctly describes the long-term effects of oral contraceptives on glucose and lipid metabolism for women with PCOS?

    <p>They have not been fully elucidated</p> Signup and view all the answers

    What should be the primary factor in deciding the first-line pharmacotherapy for women with PCOS?

    <p>Relief from menstrual irregularity, hirsutism, or acne</p> Signup and view all the answers

    What is a common treatment for women with polycystic ovary syndrome (PCOS) who do not desire pregnancy?

    <p>Oral contraceptives</p> Signup and view all the answers

    Which hormone, along with synthetic progestins, is generally effective and safe for most non-diabetic patients with PCOS?

    <p>Estradiol</p> Signup and view all the answers

    What is a potential adverse effect of oral contraceptive (OC) use in women with PCOS?

    <p>Worsened carbohydrate metabolism</p> Signup and view all the answers

    Which anti-androgen has been shown to reduce facial terminal hair growth in women with PCOS but its effects have not been proven permanent?

    <p>Cyproterone acetate</p> Signup and view all the answers

    Which anti-androgen is not widely used due to the risks of hepatotoxicity?

    <p>Flutamide</p> Signup and view all the answers

    Insulin resistance in PCOS patients can lead to an increased risk of what condition?

    <p>Heart disease and stroke</p> Signup and view all the answers

    What is the key factor in the development of Polycystic Ovary Syndrome (PCOS) related to insulin resistance?

    <p>'Normal' glucose response to insulin</p> Signup and view all the answers

    High insulin levels in PCOS patients can increase the production of what hormones?

    <p>Insulin-like growth factors</p> Signup and view all the answers

    Which medication has been shown to improve hyperandrogenic symptoms and lower testosterone concentrations in women with PCOS?

    <p>'Spironolactone'</p> Signup and view all the answers

    What is a potential concern that may limit the use of Cyproterone acetate in PCOS treatment?

    <p>Hepatotoxicity risks</p> Signup and view all the answers

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