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PCOS First-Line Pharmacotherapy Options

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Questions and Answers

What is a potential benefit of using insulin sensitizers for women with PCOS?

Increased androgen levels and hirsutism

Enhanced menstrual cyclicity and acne

Improved glucose metabolism and lipid profiles (correct)

Promotion of atherosclerosis and type 2 diabetes

Why might metformin be prescribed to women with PCOS before an insulin sensitizer?

To induce hirsutism and acne

To manage glucose metabolism and prevent weight gain (correct)

To increase androgen levels and insulin resistance

To regulate menstrual cycles and reduce circulating androgens

What role do oral contraceptives typically play in the treatment of women with PCOS?

Exacerbate insulin resistance and glucose metabolism

Promote atherosclerosis and type 2 diabetes

Increase hirsutism, acne, and weight gain

Regulate menstrual cycle, reduce circulating androgens, improve mood (correct)

Why should the decision to use metformin for women with PCOS often be patient-driven?

If the woman is overweight and has evidence of insulin resistance (A) Signup and view all the answers

Which option correctly describes the long-term effects of oral contraceptives on glucose and lipid metabolism for women with PCOS?

They have not been fully elucidated (B) Signup and view all the answers

What should be the primary factor in deciding the first-line pharmacotherapy for women with PCOS?

Relief from menstrual irregularity, hirsutism, or acne (A) Signup and view all the answers

What is a common treatment for women with polycystic ovary syndrome (PCOS) who do not desire pregnancy?

Oral contraceptives (A) Signup and view all the answers

Which hormone, along with synthetic progestins, is generally effective and safe for most non-diabetic patients with PCOS?

Estradiol (A) Signup and view all the answers

What is a potential adverse effect of oral contraceptive (OC) use in women with PCOS?

Worsened carbohydrate metabolism (B) Signup and view all the answers

Which anti-androgen has been shown to reduce facial terminal hair growth in women with PCOS but its effects have not been proven permanent?

Cyproterone acetate (C) Signup and view all the answers

Which anti-androgen is not widely used due to the risks of hepatotoxicity?

Flutamide (A) Signup and view all the answers

Insulin resistance in PCOS patients can lead to an increased risk of what condition?

Heart disease and stroke (D) Signup and view all the answers

What is the key factor in the development of Polycystic Ovary Syndrome (PCOS) related to insulin resistance?

'Normal' glucose response to insulin (B) Signup and view all the answers

High insulin levels in PCOS patients can increase the production of what hormones?

Insulin-like growth factors (A) Signup and view all the answers

Which medication has been shown to improve hyperandrogenic symptoms and lower testosterone concentrations in women with PCOS?

'Spironolactone' (D) Signup and view all the answers

What is a potential concern that may limit the use of Cyproterone acetate in PCOS treatment?

Hepatotoxicity risks (A) Signup and view all the answers