Patterns of Inheritance: Mendelian and Non-Mendelian Traits
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Questions and Answers

What type of inheritance is characterized by a single mutated gene copy being enough for the trait to manifest?

  • Autosomal Dominant (correct)
  • X-Linked Recessive
  • X-Linked Dominant
  • Autosomal Recessive
  • In X-Linked Recessive inheritance, affected males inherit the condition from their ___.

  • Both parents
  • Siblings
  • Fathers
  • Mothers (correct)
  • Which type of inheritance requires both parents to pass on the mutated gene for the trait to manifest?

  • X-Linked Dominant
  • Autosomal Recessive (correct)
  • Autosomal Dominant
  • Polygenic
  • If a trait is controlled by a single gene and follows predictable patterns based on the inheritance of alleles, it is likely an example of ___ inheritance.

    <p>Mendelian</p> Signup and view all the answers

    Which type of inheritance results in more females being affected compared to males due to females having two copies of the relevant chromosome?

    <p>X-Linked Dominant</p> Signup and view all the answers

    What term refers to the type of inheritance where both copies of the mutated gene must be present for the trait to manifest?

    <p>X-Linked Recessive</p> Signup and view all the answers

    Which of the following is an example of incomplete dominance?

    <p>Snapdragon flower color</p> Signup and view all the answers

    What type of inheritance pattern is exhibited by traits like height and weight in humans?

    <p>Polygenic inheritance</p> Signup and view all the answers

    Which of the following statements about sex-linked inheritance is correct?

    <p>Males are more likely to be affected by X-linked recessive disorders</p> Signup and view all the answers

    What is the term used to describe a single gene affecting multiple traits?

    <p>Pleiotropy</p> Signup and view all the answers

    Which of the following inheritance patterns does not follow Mendel's laws?

    <p>Multiple alleles</p> Signup and view all the answers

    In which type of inheritance pattern do both alleles contribute equally to the phenotype?

    <p>Co-dominance</p> Signup and view all the answers

    Study Notes

    Patterns of Inheritance: Mendelian, Non-Mendelian, Sex-Linked, Autosomal, and Polygenic

    Mendelian Inheritance

    Gregor Mendel, in his groundbreaking studies on pea plants, identified four main patterns of inheritance: autosomal dominant, autosomal recessive, X-linked dominant, and X-linked recessive. In Mendelian inheritance, a trait is controlled by a single gene and follows predictable patterns based on the inheritance of alleles.

    Autosomal Dominant

    A single mutated gene copy is enough to determine the presence of a trait. Both parents have a chance to pass on the mutated gene. Common example: Huntington's disease.

    Autosomal Recessive

    Both parents must pass on the mutated gene for the trait to manifest. Parents are usually unaffected and carrying the mutated gene without symptoms. Common example: Cystic Fibrosis.

    X-Linked Dominant

    One mutated gene copy is enough for the trait to manifest in all affected individuals. Women are more commonly affected since they have two copies of the X chromosome compared to men who have only one. Examples include hypophosphatemic rickets (vitamin D-resistant rickets) and ornithine transcarbamylase deficiency.

    X-Linked Recessive

    Both copies of the mutated gene must be present for the trait to manifest. Affected males inherit the condition from their mothers since fathers can only pass on Y chromosomes to male offspring. Common example: Hemophilia A.

    Non-Mendelian Inheritance

    Some genetic conditions do not follow Mendel's laws due to various factors such as multiple alleles, incomplete dominance, co-dominance, pleiotropy, lethal alleles, sex linkage, and polygenic traits.

    Multiple Alleles

    Real populations often have more than two versions of a given gene. For example, ABO blood group system has three different alleles for each location at a locus.

    Incomplete Dominance

    Two alleles may produce an intermediate phenotype when both are present. Example: Snapdragon flowers where a cross between white and red homozygotes produces wavy, intermediate-colored flowers.

    Co-Dominance

    Neither allele is dominant over the other; both contribute to the phenotype. Example: Duodenal alkaline phosphatase enzyme activity follows this pattern.

    Pleiotropy

    Single genes affect multiple traits. Example: Sickle cell disease affects hemoglobin production and oxygen transport in addition to causing sickle cells.

    Lethal Alles

    Can never survive until developmentally advanced stages. For example, some mutations in the EGFR gene cause embryonic lethality.

    Sex Linkage

    Traits linked with the sex chromosomes (X and Y). Mutations in a single copy of the gene can lead to the disorder in females but not males. X-linked diseases are usually recessive but sometimes appear to be dominant because males are affected while females are carriers.

    Polygenic Inheritance

    Involves many genes contributing to a particular trait rather than just one gene or a pair of opposing alleles. This type of inheritance makes it difficult to predict outcomes based on individual parental genotypes alone.

    A complex organism like humans exhibits continuous variation like height, weight, etc., which can't be explained by simple Mendelian patterns. Instead, these traits involve multiple genes and environmental interactions.

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    Description

    Explore the different patterns of inheritance such as Mendelian (autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive) and Non-Mendelian (multiple alleles, incomplete dominance, co-dominance, pleiotropy, lethal alleles, sex linkage). Understand how polygenic inheritance plays a role in complex traits in organisms like humans.

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