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What is the primary role of IgE antibodies in the early phase of an asthma exacerbation?
What is the primary role of IgE antibodies in the early phase of an asthma exacerbation?
What is the result of the release of cytokines from mast cells in the early phase of an asthma exacerbation?
What is the result of the release of cytokines from mast cells in the early phase of an asthma exacerbation?
What is the primary component of the early asthmatic response?
What is the primary component of the early asthmatic response?
What is the effect of the release of histamine from mast cells in the early phase of an asthma exacerbation?
What is the effect of the release of histamine from mast cells in the early phase of an asthma exacerbation?
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What is the outcome of the simultaneous release of cytokines and degranulation of mast cells in the early phase of an asthma exacerbation?
What is the outcome of the simultaneous release of cytokines and degranulation of mast cells in the early phase of an asthma exacerbation?
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During the early phase of an asthma exacerbation, what is the effect ofmast cells on the airway?
During the early phase of an asthma exacerbation, what is the effect ofmast cells on the airway?
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Study Notes
Pathophysiology of Asthma Exacerbation
- There are two phases of an asthma exacerbation: the early phase and late phase.
- The early phase is initiated by IgE antibodies that are sensitized and released by plasma cells.
- IgE antibodies respond to certain triggers in the environment, such as risk factors, and bind to high-affinity mast cells and basophils.
- When a pollutant or risk factor is inhaled, the mast cells release cytokines and eventually de-granulate.
- Released from mast cells are histamine, prostaglandins, and leukotrienes.
- Simultaneously, cytokines derived from the mast cell will signal other inflammatory cells and their mediators to the lung.
- The result is airway inflammation, increased vascular permeability, mucus secretion, bronchospasm, and wheezing.
- These events are referred to as the early asthmatic response because they occur within minutes.
- A major component of the early response is bronchospasm.
Key Components of Early Asthmatic Response
- Airway inflammation
- Increased vascular permeability
- Mucus secretion
- Bronchospasm
- Wheezing
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Description
This quiz covers the two phases of an asthma exacerbation, including the early phase triggered by IgE antibodies and the late phase, and the role of mast cells and cytokines.
