55 Questions
What is the key factor in determining whether a bone tumor is benign or malignant based on cellular features?
Rate of growth
In the context of bone tumors, what is the significance of 'location' according to the text?
Affects the likelihood of the tumor being benign or malignant
Why are osteomas considered rare benign tumors according to the text?
They are typically asymptomatic
Which bone tumor is predominantly located at the epiphysis of bones?
Giant cell tumor
What is a common feature shared by fibrous dysplasia and aneurysmal bone cysts?
Both are benign bone tumors
Why is considering the cellular appearance crucial in determining the nature of a bone lesion?
To assess whether it is likely benign or malignant
Which bone tumor is characterized by being relieved by aspirin?
Osteoid osteoma
Which bone tumor is known as the 'giant osteoid osteoma'?
Osteoblastoma
Which bone tumor has an identical histologic appearance to osteoid osteoma?
Osteoblastoma
In which age group does osteosarcoma commonly occur?
Teens- twenties
Which bone tumor produces osteoid and can sometimes make cartilage?
Chondrosarcoma
What is the most common primary malignant tumor of bone?
Osteosarcoma
What is the significance of the 'location, location, location' phrase in relation to bone tumors?
It emphasizes the impact of the anatomical site of bone tumors on their diagnosis and treatment.
What distinguishes an osteoma from other bone tumors?
Presence of osteoid in the tumor cells
Why are chondromyxoid fibromas considered distinct among cartilage-forming bone tumors?
They exhibit a unique mix of cartilaginous and fibrous elements.
What factor is crucial in determining whether a bone lesion is benign or malignant based on cellular features?
The degree of cellular atypia observed
In terms of bone tumors, what does the pattern of growth help determine?
The aggressiveness of the tumor
What differentiates fibrous dysplasia from osteoid osteoma based on radiographic appearance?
Presence of ground-glass matrix in osteoid osteoma
What is a distinguishing feature between osteoid osteoma and osteoblastoma in terms of pain relief?
The pain is relieved by aspirin in osteoid osteoma but not in osteoblastoma
Which bone tumor is characterized by a central radiolucent nidus surrounded by a sclerotic rim on X-ray?
Osteoid osteoma
What is the distinguishing radiological feature between osteoblastoma and osteosarcoma?
Lack of sclerotic rim around the nidus
Which bone tumor is the most common primary malignant tumor of bone?
Osteosarcoma
In which age group do osteoblastomas typically occur?
Teens-twenties
What is a distinguishing characteristic between osteosarcoma and both osteoid osteoma and osteoblastoma?
Production of unmineralized bone matrix
What aspect of a bone lesion is crucial in determining if it is more likely benign or malignant?
Cellular features
Which bone tumor exhibits a central radiolucent nidus surrounded by a sclerotic rim on X-ray?
Aneurysmal bone cyst
What is a distinguishing histologic feature of osteoid osteoma that sets it apart from other bone tumors?
Presence of osteoid
In the context of bone tumors, what is the significance of the 'location, location, location' phrase?
Highlights the importance of anatomical location in differential diagnosis
Which bone tumor is known as the 'giant osteoid osteoma' due to its similar histologic appearance?
Osteoblastoma
'Location, location, location' in relation to bone tumors primarily refers to:
The impact of tumor location on prognosis and management
Which bone tumor is most likely to have a radiolucent nidus and less or no sclerotic rim on X-ray?
Osteoid osteoma
In which age group is osteoblastoma most commonly seen?
Teens-twenties
What is the distinguishing feature between osteoid osteoma and osteosarcoma in terms of pain?
Pain not relieved by aspirin
Which bone tumor is characterized by producing osteoid and sometimes cartilage?
Osteosarcoma
What is the most common primary malignant tumor of bone?
Osteosarcoma
Which bone tumor is known as the 'giant osteoid osteoma'?
Osteoblastoma
What differentiates osteoid osteoma and osteoblastoma in terms of pain relief?
Pain in osteoid osteoma is relieved by aspirin, while pain in osteoblastoma is not
Which bone tumor shares an identical histologic appearance with osteoblastoma?
Osteoid osteoma
What is a distinguishing radiological feature of osteosarcoma compared to osteoid osteoma and osteoblastoma?
Sclerotic rim around the tumor
What is a unique characteristic of the radiological appearance of osteoblastoma compared to other bone tumors?
Surrounded by sclerotic bone rim on X-ray
In terms of size, what differentiates osteoid osteoma from osteoblastoma?
Osteoid osteoma is smaller than 2 cm, while osteoblastoma is larger
What is a distinguishing characteristic between osteosarcoma and both osteoid osteoma and osteoblastoma?
Malignant transformation potential
What aspect is crucial in determining if a bone lesion is more likely benign or malignant based on cellular features?
The cellular morphology of the lesion
What is the primary factor in determining whether a bone lesion is benign or malignant?
The cellular features of the lesion
Which bone tumor is predominantly located at the diaphysis of bones?
Ewing sarcoma
What sets osteoma apart from other bone tumors?
It is a rare benign tumor of mature bone
In terms of radiographic appearance, what feature distinguishes fibrous dysplasia from osteoid osteoma?
Surrounded by a sclerotic rim
Which bone tumor is characterized by being relieved by aspirin?
Osteoid osteoma
What does the phrase 'location, location, location' primarily refer to in the context of bone tumors?
The anatomical location of the tumor within the bone
What characteristic differentiates osteoid osteoma from osteoblastoma in terms of pain relief?
Pain is relieved by aspirin in osteoid osteoma but not in osteoblastoma
What is the distinguishing characteristic of the radiological appearance of osteosarcoma compared to osteoid osteoma and osteoblastoma?
Absence of central area (nidus)
What is a distinguishing feature of the histologic appearance of both osteoid osteoma and osteoblastoma?
Interlacing trabeculae of woven bone surrounded by osteoblasts
Which bone tumor has a bimodal age distribution and is most common as a primary malignant tumor of bone?
Osteosarcoma
In contrast to osteoid osteoma, which bone tumor exhibits a central radiolucent nidus surrounded by a sclerotic rim on X-ray?
Osteoblastoma
What characteristic differentiates the pain relief pattern between osteoid osteoma and osteosarcoma?
Pain is relieved by aspirin in both
Study Notes
Bone Tumors: Characteristics and Classification
Osteoma
- Rare benign tumor of mature bone
- Age: 40-50 years old
- Site: cortical bones of skull and face
- X-ray: well-delimited nodule
- Prognosis: good (simple excision), slow-growing, not invasive, no malignant transformation
- May cause local and mechanical problems (e.g. sinus obstruction; osteoma in endosteal surface of brain)
Osteoid Osteoma & Osteoblastoma
- Benign neoplasms with identical histology
- Differ in size, sites of origin, X-ray features, and symptoms
- Osteoblastoma = "giant osteoid osteoma"
- X-ray: central area of tumor (nidus); usually radiolucent, surrounded by rim of sclerotic bone
- Both painful lesions, but pain is relieved by aspirin in osteoid osteoma, not in osteoblastoma
Osteoblastoma
- Age: teens to twenties
- Site: vertebral column, other
- Size: > 2 cm
- X-ray: radiolucent nidus, less (or no) sclerotic rim
- Prognosis: good, if totally excised
- Histologic appearance: interlacing trabeculae of woven bone surrounded by osteoblasts; loose connective tissue stroma (no marrow elements); may see giant cells
- Pain not relieved by aspirin
Osteosarcoma
- Malignant mesenchymal tumor
- Neoplastic cells produce osteoid (unmineralized bone matrix); sometimes makes cartilage
- Most common 1° malignant tumor of bone (20% of 1° bone malignancies)
- M:F = 1.6:1
- Bimodal age distribution: 75% occur in patients
General Locations of Bone Tumors
- Diaphysis: Ewing sarcoma, chondrosarcoma
- Metaphysis: osteosarcoma
- Physis: giant cell tumor
- Epiphysis: various tumors
Systematic Approach to Bone Tumors
- What is the lesion's pattern of growth?
- Are the cells of the lesion producing anything?
- What do the cells of the lesion look like?
- Based on cellular features and imaging studies, is the lesion more likely benign or malignant?
- Does the anatomical diagnosis (i.e. pathology) correlate with the clinical picture and radiographic appearance of the lesion?
Test your knowledge on neoplastic disorders of bone with a systematic approach. Answer 5 questions relating to the growth pattern, cell characteristics, and likelihood of benign or malignant nature of the lesion.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
