Pathology Lecture 1: Arterial Atherosclerosis and Arteriosclerosis

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Questions and Answers

What is the main characteristic of atherosclerosis?

  • Increased extracellular matrix with reduced lipids
  • Patches of intimal thickening and accumulation of lipids (correct)
  • Inflammatory cells without intimal thickening
  • Proliferation of smooth muscle cells only

Which risk factor is considered a constitutional (fixed) risk factor for atherosclerosis?

  • High lipoprotein A
  • Inflammation
  • Reduced physical activity
  • Male gender (correct)

What is the pathogenesis of atherosclerosis according to the reaction to injury hypothesis?

  • Injury to vessel wall leads to chronic inflammation but no healing response
  • No injury to vessel wall results in increased extracellular matrix
  • Healing response occurs without chronic inflammation
  • Chronic inflammation and healing response due to injury to vessel wall (correct)

What is the main characteristic of arteriosclerosis?

<p>Stiffening and loss of elasticity in arteries (B)</p> Signup and view all the answers

Which type of aneurysm involves a tear in the inner layer of the artery wall?

<p>Dissecting aneurysm (C)</p> Signup and view all the answers

What is the composition of fatty streaks in atherosclerosis?

<p>Lipid-filled foamy macrophages (C)</p> Signup and view all the answers

Which vessels are most extensively involved in atherosclerotic lesions?

<p>Coronary arteries and popliteal arteries (B)</p> Signup and view all the answers

What is the main stage of biobodexi in atherosclerosis?

<p>Release of cytokines (D)</p> Signup and view all the answers

What is the characteristic feature of atheromas on cross-sectioning?

<p>Soft, lipid-rich center covered with smooth muscle cells (D)</p> Signup and view all the answers

What is present in the necrotic core of atherosclerotic plaques?

<p>Cholesterol crystals and foam cells (D)</p> Signup and view all the answers

What tissue changes are associated with acute plaque changes in atherosclerosis?

<p>Erosion, ulceration, or rupture (D)</p> Signup and view all the answers

What is the primary cause of the yellow color of atheromas?

<p>Presence of cholesterol crystals and foam cells (B)</p> Signup and view all the answers

What are the earliest recognizable lesions in atherosclerosis?

<p>&quot;Elongated streaks&quot; (D)</p> Signup and view all the answers

What is the characteristic feature of atherosclerotic lesions on cross-sectioning?

<p>&quot;Eccentric&quot; appearance due to patchy lesions (B)</p> Signup and view all the answers

What are the components of a fibrous cap in atherosclerotic plaques?

<p>(Smooth muscle cells, macrophages, foam cells) (A)</p> Signup and view all the answers

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