Pathology: Hypersensitivity Reactions Study Notes
16 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the cause of hypersensitivity reaction?

  • Inheritance of susceptibility genes
  • Imbalance between effector cells & regulatory mechanisms (correct)
  • Exaggerated immune response to antigens
  • Presence of environmental antigens

Which type of immune diseases does hypersensitivity fall under?

  • Autoimmune (self react)
  • Immunodeficiency (under react) (correct)
  • Both autoimmune and immunodeficiency
  • None of the above

What cells are involved in hypersensitivity reactions?

  • Epithelial cells
  • Endothelial cells
  • Cells of the immune response (correct)
  • Red blood cells

Who does hypersensitivity affect?

<p>Only sensitized individuals (B)</p> Signup and view all the answers

Which type of hypersensitivity reaction is associated with IgE bound to mast cells and basophils?

<p>Type I immediate hypersensitivity reaction (A)</p> Signup and view all the answers

What elicits hypersensitivity reactions?

<p>Exogenous (environmental) antigens and endogenous (self) antigens (B)</p> Signup and view all the answers

What is the characteristic feature of atopic individuals?

<p>High serum IgE levels (C)</p> Signup and view all the answers

Which antibody is stimulated by TH2 and binds to FC receptors on the surface of effector cells?

<p>IgE (A)</p> Signup and view all the answers

What is the main effect of histamine in hypersensitivity reactions?

<p>Vasodilation and increased permeability of blood vessels (A)</p> Signup and view all the answers

What is the dominant inflammatory cell in the late phase reaction of hypersensitivity I?

<p>Neutrophils (C)</p> Signup and view all the answers

Which type of reaction occurs 5-30 minutes after re-exposure to an allergen?

<p>Early phase reaction (B)</p> Signup and view all the answers

What is the clinical manifestation of systemic (anaphylactic shock) in sensitized individuals?

<p>Profound respiratory distress (B)</p> Signup and view all the answers

Which effector cells are sensitized by IgE in hypersensitivity I?

<p>Mast cells and basophils (D)</p> Signup and view all the answers

What is the main effect of prostaglandins in hypersensitivity I?

<p>Muscle spasm (B)</p> Signup and view all the answers

Which type of cell produces IL-5, which activates eosinophils in the late phase reaction?

<p>TH2 cells (A)</p> Signup and view all the answers

What is the role of leukotrienes in hypersensitivity I reactions?

<p>Smooth muscle spasm (B)</p> Signup and view all the answers

More Like This

Use Quizgecko on...
Browser
Browser