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Pathological Fracture Laboratory Work-up Quiz

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Pathological Fracture Laboratory Work-up Quiz

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Questions and Answers

Which criterion is part of the diagnostic criteria for multiple myeloma?

Elevated white blood cell count

Presence of M component in blood (correct)

Low platelet count

High red blood cell count

What diagnostic tests are recommended for evaluating plasma dyscrasia?

Blood film, chemistry including calcium and creatinine, and bone marrow aspirate & biopsy

Serum protein electrophoresis, quantification of immunoglobulins, and CT or MRI (correct)

Complete blood count, urine culture, and liver function tests

CT or MRI, blood culture, and urine dipstick test

What is the threshold for serum calcium elevation in the CRAB criteria for multiple myeloma?

Serum calcium >11.5 mg/dL (correct)

Serum calcium >13.5 mg/dL

Serum calcium >10.5 mg/dL

Serum calcium >12.5 mg/dL

What impacts the aggressiveness of multiple myeloma?

Several variables that impact disease biology Signup and view all the answers

What is the primary cause of pruritus in the context of the given text?

Increased histamine release from basophils and mast cells Signup and view all the answers

Which mutation is typically associated with Polycythemia Vera?

JAK2V617F Signup and view all the answers

What characterizes bone marrow biopsy in Polycythemia Vera?

Hypercellularity for age with trilineage growth Signup and view all the answers

What is the main stimulus for hyperproliferation of fibroblasts in myelofibrosis?

PDGF, EGF, TGF-β released from myeloid cells Signup and view all the answers

What is the predominant phenotypic expression of the myeloproliferative clone in Polycythemia Vera (PV)?

Erythroid proliferation Signup and view all the answers

Which clinical feature is present in approximately 40% of patients at the time of diagnosis of Polycythemia Vera (PV)?

Splenomegaly Signup and view all the answers

What is a common complication of Polycythemia Vera (PV) that can lead to impaired oxygen delivery?

Erythrocytosis and hyperviscosity Signup and view all the answers

What may be observed on examination of the eye grounds in patients with Polycythemia Vera (PV)?

Engorged, tortuous, and irregular vessels Signup and view all the answers