Pathological Anatomy and Physiology Quiz

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Questions and Answers

Which of the following factors contributes to the development of thrombosis?

  • Blood flow disorder (correct)
  • Pulmonary embolism
  • Endothelial injury (correct)
  • Air embolism

An embolism is caused by a substance moving through the bloodstream and causing a blockage.

True (A)

What is the most common type of embolism?

Thrombembolism

Edema is the accumulation of ______ in tissues.

<p>fluid</p> Signup and view all the answers

Match the following skin pigmentation disorders with their descriptions:

<p>Albinism = Lack of pigmentation in the skin, hair, and eyes Vitiligo = Loss of skin color in patches Freckles = Small brown spots on the skin due to sun exposure</p> Signup and view all the answers

What are the systemic manifestations of inflammation?

<p>Fever (B)</p> Signup and view all the answers

Regeneration refers to healing in which the original tissue functionality is completely restored.

<p>True (A)</p> Signup and view all the answers

What is the term for the sudden, intermittent pain caused by muscle contractions due to a stone?

<p>Colic</p> Signup and view all the answers

What is the recommended age for women to start cervical cancer screening in the Czech Republic?

<p>25 years (A)</p> Signup and view all the answers

The most common tumors in women include breast, lung, and colorectal cancers.

<p>True (A)</p> Signup and view all the answers

Name one example of a benign tumor.

<p>Adenoma</p> Signup and view all the answers

Increased blood pressure above _______ indicates systemic arterial hypertension.

<p>140/90 mmHg</p> Signup and view all the answers

Match each type of tumor with its corresponding category:

<p>Liposarcoma = Mesenchymal tumors (malignant) Adenocarcinoma = Epithelial tumors (malignant) Papilloma = Epithelial tumors (benign) Leukemia = Hematological tumors (malignant)</p> Signup and view all the answers

Which of the following tumors is not a common cancer in children?

<p>Colorectal cancer (A)</p> Signup and view all the answers

What is secondary hypertension?

<p>High blood pressure caused by another condition.</p> Signup and view all the answers

A cyst is defined as a cavity without any lining.

<p>False (B)</p> Signup and view all the answers

Which of the following is a consequence of systemic hypertension?

<p>Kidney damage leading to kidney failure (A)</p> Signup and view all the answers

Aortic dissection is characterized by a localized enlargement of an artery.

<p>False (B)</p> Signup and view all the answers

What condition leads to disruption of diastolic filling of the heart due to myocardial rupture?

<p>Cardiac tamponade (A)</p> Signup and view all the answers

What is the main risk associated with iliofemoral phlebothrombosis?

<p>High risk of embolism</p> Signup and view all the answers

Angina pectoris is a form of _______ ischemia.

<p>reversible</p> Signup and view all the answers

Symptoms of right-sided heart failure primarily include pulmonary symptoms.

<p>False (B)</p> Signup and view all the answers

What is the typical course of acute rhinitis?

<p>Self-limiting viral infection causing nasal congestion and discharge.</p> Signup and view all the answers

Match each risk factor for coronary heart disease to its type:

<p>Hypertension = Modifiable Age = Non-modifiable Smoking = Modifiable Genetics = Non-modifiable</p> Signup and view all the answers

What are the two basic types of valvular disorders?

<p>Narrowing and insufficiency (C)</p> Signup and view all the answers

Pulmonary edema limits or prevents gas exchange due to the presence of _____ in the pulmonary interstitium.

<p>fluid</p> Signup and view all the answers

What is atherosclerosis?

<p>Formation of atherosclerotic plaques in arterial walls</p> Signup and view all the answers

Match the following obstructive pulmonary diseases with their causes:

<p>Bronchial Asthma = Bronchial inflammation and narrowing COPD = Long-term inflammation and damage due to smoking Bronchiectasis = Chronic infection and damage to the airways</p> Signup and view all the answers

Which of the following is a common cause of pulmonary hypertension?

<p>Idiopathic factors (C)</p> Signup and view all the answers

Chronic, excessive stress is a non-modifiable risk factor for coronary heart disease.

<p>False (B)</p> Signup and view all the answers

Pulmonary atelectasis occurs when there is excessive air in the lungs.

<p>False (B)</p> Signup and view all the answers

What is angina?

<p>Acute infection of the tonsils commonly caused by streptococci.</p> Signup and view all the answers

Which type of diabetes is characterized by an absolute lack of insulin secretion?

<p>Type 1 Diabetes (D)</p> Signup and view all the answers

Chronic hyperglycemia in diabetes mellitus can be caused by both impaired insulin secretion and action.

<p>True (A)</p> Signup and view all the answers

What are two acute complications of diabetes mellitus?

<p>Hypoglycemia and diabetic ketoacidosis</p> Signup and view all the answers

The condition characterized by a high level of proteinuria (over 3.5g/day) is known as ________.

<p>nephrotic syndrome</p> Signup and view all the answers

Match the following chronic complications of diabetes with their descriptions:

<p>Neuropathy = Nerve damage leading to numbness Nephropathy = Kidney damage affecting filtration Retinopathy = Vision impairment due to retinal damage Atherosclerosis = Hardening of the arteries</p> Signup and view all the answers

What is the most common cause of chronic kidney insufficiency?

<p>Glomerulonephritis (A)</p> Signup and view all the answers

Acute renal failure can be caused solely by prerenal mechanisms.

<p>False (B)</p> Signup and view all the answers

What is hydronephrosis?

<p>A condition in which urine outflow from the renal pelvis is obstructed</p> Signup and view all the answers

Which of the following is NOT a manifestation of acute bladder inflammation?

<p>Polydipsia (B)</p> Signup and view all the answers

Vesicoureteral reflux can lead to kidney damage and infections.

<p>True (A)</p> Signup and view all the answers

What is a polyp?

<p>A circumscribed protrusion of the mucosa into the lumina.</p> Signup and view all the answers

The acidic contents of the stomach can flow back into the esophagus due to a _______ lower esophageal sphincter.

<p>weak</p> Signup and view all the answers

Match the following mechanisms of diarrhea with their descriptions:

<p>Osmotic = Diarrhea caused by unabsorbed substances in the intestines Secretory = Diarrhea due to excessive secretion of fluids into the intestines Exudative = Diarrhea with the presence of blood and pus Motility disorders = Diarrhea related to abnormal intestinal movement</p> Signup and view all the answers

What risk factors are associated with developing urolithiasis?

<p>All of the above (D)</p> Signup and view all the answers

Chronic pancreatitis involves transient inflammation without any fibrosis.

<p>False (B)</p> Signup and view all the answers

A hiatal hernia is the dislocation of part of the stomach through the esophageal _______.

<p>hiatus</p> Signup and view all the answers

Flashcards

What is thrombosis?

The formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

What is an embolism?

A substance, often a blood clot, that travels through the bloodstream and lodges in a blood vessel, causing a blockage.

What is edema?

The accumulation of fluid in body tissues, leading to swelling.

What is lithiasis?

The presence of concrements (stones) in the body within the excretory systems of certain organs.

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What is colic?

Sudden, intermittent pain from muscle contractions caused by a stone moving through excretory pathways.

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What is inflammation?

A defensive and reparative response to tissue damage, part of the innate immune system.

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What is regeneration?

The healing of a lesion with the original tissue maintaining its functionality.

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What is reparation?

The healing of a lesion with functionally inferior tissue, usually a fibrous scar.

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Paraneoplastic Syndrome

Symptoms in advanced cancer patients not directly related to the tumor mass, often caused by endocrine, autoimmune, or coagulation disorders.

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Benign Tumor

A tumor with abnormal cell growth that does not spread to other parts of the body.

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Malignant Tumor

A tumor with abnormal cell growth that can spread to other parts of the body.

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Cyst

A cavity surrounded by epithelial lining.

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Systemic Arterial Hypertension

Increased blood pressure above 140/90 mmHg (repeated measurements at rest, minimum of 2 times across three doctor visits).

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Secondary Hypertension

High blood pressure caused by another condition, such as kidney disorders, endocrine problems, or aortic narrowing.

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Primary (Essential) Hypertension

High blood pressure without a known cause.

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Tumor Cell Transformation (Oncogenesis)

The process of normal cells turning into cancerous cells, caused by genetic changes altering cell growth, death, and invasion.

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What is systemic hypertension?

High blood pressure that can damage organs like the heart, brain, and kidneys.

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What is atherosclerosis?

A buildup of plaque in arteries, narrowing them and potentially cutting off blood flow.

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What's the difference between an aneurysm and an aortic dissection?

A bulge in an artery caused by weakness in the wall, or a tear in the aorta causing blood flow between layers.

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Define aneurysm and aortic dissection.

Aneurysm: bulging artery; Dissection: tear in aorta.

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What are varices, and where do they occur?

Enlarged veins, often in the legs or esophagus, due to increased pressure or liver disease.

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What's the difference between superficial thrombophlebitis and iliofemoral phlebothrombosis?

Superficial thrombophlebitis is inflammation in surface veins with low embolism risk, while iliofemoral phlebothrombosis affects deep veins and has high embolism risk.

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Name the two basic types of valvular disorders.

Narrowing (stenosis) or backflow (insufficiency) of valves.

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What is coronary heart disease (CHD)?

Ischemia caused by atherosclerosis in the coronary arteries.

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What is heart failure?

A condition where the heart cannot effectively pump blood, leading to inadequate tissue perfusion. It can be classified based on the location of the malfunction (left or right side) and the presence or absence of shunts.

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What is cardiac tamponade?

A life-threatening condition where fluid accumulates in the space between the heart and the pericardium, preventing the heart from filling properly.

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What is pulmonary atelectasis?

A condition where the lung tissue collapses due to air absorption and alveolar collapse. This can result from blocked airways or pressure on the lung.

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What is pulmonary edema?

A condition where fluid accumulates in the spaces around the air sacs (alveoli) in the lungs, making it difficult for oxygen to reach the bloodstream. It can be caused by various factors, including heart failure and lung injuries.

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What is pulmonary hypertension?

High blood pressure in the arteries of the lungs, which can lead to right heart failure and damage to the lungs. It can be caused by various factors, including lung disease, heart defects, and certain medications.

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What is pulmonary embolism?

A blockage in the pulmonary artery, usually caused by a blood clot that travels from the legs or other parts of the body. It can be very dangerous and lead to respiratory failure.

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What is ARDS (Acute Respiratory Distress Syndrome)?

A severe form of lung injury that causes fluid to leak into the alveoli, leading to difficulty breathing. This can be caused by various factors, including infection, trauma, and aspiration.

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What are the three most important obstructive pulmonary diseases?

A group of inflammatory lung diseases that cause airflow obstruction. This can lead to coughing, wheezing, and shortness of breath. The three most common causes of obstruction are inflammation, airway narrowing, and chronic infection.

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What is diabetes mellitus (DM)?

A group of metabolic disorders characterized by chronic high blood sugar (hyperglycemia) due to problems with insulin production, insulin action, or both.

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What is type 1 diabetes?

Type 1 diabetes is caused by the body's immune system attacking and destroying the insulin-producing cells in the pancreas. This leads to an absolute lack of insulin.

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What is type 2 diabetes?

Type 2 diabetes occurs when the body doesn't use insulin properly, leading to insulin resistance. Over time, the pancreas may not be able to produce enough insulin to overcome this resistance.

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What is uremia?

A condition caused by kidney failure, especially in end-stage renal disease (ESRD), leading to a buildup of waste products in the blood.

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What is nephrotic syndrome?

A group of symptoms caused by high protein levels in the urine (over 3.5 grams per day).

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What is hydronephrosis?

A condition where the flow of urine from the kidneys is blocked, causing the kidneys to swell.

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What is acute pyelonephritis?

A bacterial infection of the kidneys and renal pelvis, causing pus (inflammation).

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What is hyperkalemia and how is it dangerous?

A potentially life-threatening condition occurring in acute kidney failure, characterized by high potassium levels in the blood, leading to heart rhythm problems.

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Cystitis

Inflammation of the bladder, characterized by pain or burning during urination (dysuria), blood in the urine (hematuria), frequent urination (pollakiuria), and a strong urge to urinate (urgency).

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Vesicoureteral Reflux (VUR)

Urine flows backward from the bladder into the ureters, potentially leading to kidney infections and damage.

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Dysphagia

A disruption in the normal process of swallowing, leading to difficulty or pain in moving food or liquid from the mouth to the stomach.

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Gastroesophageal Reflux Disease (GERD)

The backward flow of acidic stomach contents into the esophagus due to a weak lower esophageal sphincter, causing discomfort and potential complications.

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Hiatal Hernia

A protrusion of the stomach through the esophageal hiatus of the diaphragm into the chest area.

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Peptic Ulcer

A breakdown of the protective lining in the stomach or duodenum due to the combined effects of acid and the bacterium Helicobacter pylori.

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Polyp

A pouch-like protrusion of the mucosal lining into the lumen of an organ, usually the colon.

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Ileus

A life-threatening intestinal obstruction caused by mechanical blockage (e.g., tumors), paralysis of muscle movements (neurogenic), or insufficient blood supply (vascular).

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Study Notes

Pathological Anatomy and Physiology

  • Pathological anatomy studies structural changes caused by disease in tissues and organs.
  • Pathological physiology examines the functional changes in the body during disease.
  • Etiology refers to the cause of a disease.
  • Pathogenesis describes the mechanism of disease development.

Types of Autopsies

  • Clinical autopsies analyze the cause of a patient's death.
  • Forensic autopsies investigate suspicious deaths.
  • Anatomical autopsies are for research and education.

Biopsy and Cytology

  • Biopsy involves the removal and examination of a tissue sample from a living patient.
  • Cytology examines cells from swabs or liquids (excluding blood).

Molecular Pathological Examination

  • Detects genetic changes in tumor cells, used for diagnosis and predicting disease progression.

Stages of Dying

  • Clinical death is reversible.
  • Biological death is irreversible.

Brain Death Diagnosis

  • Diagnosed by clinical assessment (absence of brainstem reflexes, breathing, and electrical activity).
  • Confirmatory testing includes cerebral angiography and brain perfusion scintigraphy.

Adaptation

  • Adaptation is a reversible change in function and structure in response to increased or decreased demands on the organism.
  • Types: hypertrophy, hyperplasia, atrophy, and metaplasia.

Hypertrophy vs. Hyperplasia

  • Hypertrophy is an increase in the size of cells.
  • Hyperplasia is an increase in the number of cells.

Atrophy

  • A decrease in cell size or volume. Examples include brain and testicular atrophy.

Metaplasia

  • Replacement of one type of differentiated cell with another.

Cell Death Types

  • Necrosis is uncontrolled cell death.
  • Apoptosis is regulated, programmed cell death.

Infarction

  • Tissue death due to lack of blood supply.

Gangrene

  • Necrosis modified by secondary changes, such as drying, infection by bacteria.

Pressure Ulcer

  • Necrosis of skin and subcutaneous tissue due to prolonged pressure, often over bony areas in immobile patients.

Thrombosis

  • Intravital clot formation in blood vessels. Factors contributing are endothelial injury, blood flow disorders, and the hypercoagulable state.

Embolism

  • A substance (embolus) that travels through the bloodstream and blocks a vessel.
  • Common types: thromboembolism, air embolism, fat embolism, amniotic fluid embolism, and tumor embolism.

Edema

  • Accumulation of fluid in tissues due to mechanisms such as venous stasis, hypoproteinemia, sodium and water retention, and lymphedema.

Dehydration Signs

  • Reduced fluid intake, diarrhea, vomiting, sweating, urine loss, fluid loss from burns.

Marfan Syndrome

  • Genetic disorder affecting connective tissue (fibrillin gene), leading to tall stature, aortic defects, hypermobility, and flat feet and long limbs.

Amyloid/Amyloidosis

  • A disease where soluble proteins convert into insoluble proteins that accumulate in tissues.
  • Key role in Alzheimer's disease.

Skin Pigmentation Disorders

  • Albinism, vitiligo, and freckles.

Lithiasis

  • Presence of concrements in excretory systems.

Colic

  • Sudden, intermittent pain from muscle contractions in excretory pathways.

Inflammation

  • Defensive and reparative response to tissue damage, a part of the innate immune system.
  • Local manifestations include rubor, dolor, calor, tumor, and functio laesa.
  • Systemic manifestations include leukocytosis, leukopenia, increased acute-phase proteins, increased coagulation, sedimentation and fever.

Abscess vs. Phlegmon

  • Abscess involves a localized collection of pus.
  • Phlegmon is diffuse tissue inflammation.

Healing Types

  • Regeneration is healing of a lesion, maintaining original tissue function.
  • Reparation is healing of a lesion with a fibrous scar.

Fracture Healing

  • Fracture healing involves hematoma formation, granulation tissue formation, cartilage callus formation, bone callus formation, and bone callus remodeling.

Immunity

  • Innate immunity (general defense, no memory) and adaptive immunity (memory, involves T and B cells, specific immunity) protect against pathogens.

Low Immune System Activity

  • Immunodeficiency diseases, immunosuppressive treatments, malnutrition and congenital or acquired immune system deficiencies.

Exaggerated Immune Reactions

  • Allergies, and autoimmune diseases (e.g. rheumatoid arthritis, lupus).

Trisomy

  • A genetic condition where a chromosome has three copies instead of two. Example: Down syndrome (trisomy 21).

Teratogen

  • An external factor that can cause developmental disorders, such as alcohol or medications.

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