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Questions and Answers
Which of the following factors contributes to the development of thrombosis?
Which of the following factors contributes to the development of thrombosis?
An embolism is caused by a substance moving through the bloodstream and causing a blockage.
An embolism is caused by a substance moving through the bloodstream and causing a blockage.
True (A)
What is the most common type of embolism?
What is the most common type of embolism?
Thrombembolism
Edema is the accumulation of ______ in tissues.
Edema is the accumulation of ______ in tissues.
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Match the following skin pigmentation disorders with their descriptions:
Match the following skin pigmentation disorders with their descriptions:
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What are the systemic manifestations of inflammation?
What are the systemic manifestations of inflammation?
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Regeneration refers to healing in which the original tissue functionality is completely restored.
Regeneration refers to healing in which the original tissue functionality is completely restored.
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What is the term for the sudden, intermittent pain caused by muscle contractions due to a stone?
What is the term for the sudden, intermittent pain caused by muscle contractions due to a stone?
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What is the recommended age for women to start cervical cancer screening in the Czech Republic?
What is the recommended age for women to start cervical cancer screening in the Czech Republic?
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The most common tumors in women include breast, lung, and colorectal cancers.
The most common tumors in women include breast, lung, and colorectal cancers.
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Name one example of a benign tumor.
Name one example of a benign tumor.
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Increased blood pressure above _______ indicates systemic arterial hypertension.
Increased blood pressure above _______ indicates systemic arterial hypertension.
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Match each type of tumor with its corresponding category:
Match each type of tumor with its corresponding category:
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Which of the following tumors is not a common cancer in children?
Which of the following tumors is not a common cancer in children?
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What is secondary hypertension?
What is secondary hypertension?
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A cyst is defined as a cavity without any lining.
A cyst is defined as a cavity without any lining.
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Which of the following is a consequence of systemic hypertension?
Which of the following is a consequence of systemic hypertension?
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Aortic dissection is characterized by a localized enlargement of an artery.
Aortic dissection is characterized by a localized enlargement of an artery.
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What condition leads to disruption of diastolic filling of the heart due to myocardial rupture?
What condition leads to disruption of diastolic filling of the heart due to myocardial rupture?
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What is the main risk associated with iliofemoral phlebothrombosis?
What is the main risk associated with iliofemoral phlebothrombosis?
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Angina pectoris is a form of _______ ischemia.
Angina pectoris is a form of _______ ischemia.
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Symptoms of right-sided heart failure primarily include pulmonary symptoms.
Symptoms of right-sided heart failure primarily include pulmonary symptoms.
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What is the typical course of acute rhinitis?
What is the typical course of acute rhinitis?
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Match each risk factor for coronary heart disease to its type:
Match each risk factor for coronary heart disease to its type:
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What are the two basic types of valvular disorders?
What are the two basic types of valvular disorders?
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Pulmonary edema limits or prevents gas exchange due to the presence of _____ in the pulmonary interstitium.
Pulmonary edema limits or prevents gas exchange due to the presence of _____ in the pulmonary interstitium.
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What is atherosclerosis?
What is atherosclerosis?
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Match the following obstructive pulmonary diseases with their causes:
Match the following obstructive pulmonary diseases with their causes:
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Which of the following is a common cause of pulmonary hypertension?
Which of the following is a common cause of pulmonary hypertension?
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Chronic, excessive stress is a non-modifiable risk factor for coronary heart disease.
Chronic, excessive stress is a non-modifiable risk factor for coronary heart disease.
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Pulmonary atelectasis occurs when there is excessive air in the lungs.
Pulmonary atelectasis occurs when there is excessive air in the lungs.
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What is angina?
What is angina?
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Which type of diabetes is characterized by an absolute lack of insulin secretion?
Which type of diabetes is characterized by an absolute lack of insulin secretion?
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Chronic hyperglycemia in diabetes mellitus can be caused by both impaired insulin secretion and action.
Chronic hyperglycemia in diabetes mellitus can be caused by both impaired insulin secretion and action.
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What are two acute complications of diabetes mellitus?
What are two acute complications of diabetes mellitus?
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The condition characterized by a high level of proteinuria (over 3.5g/day) is known as ________.
The condition characterized by a high level of proteinuria (over 3.5g/day) is known as ________.
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Match the following chronic complications of diabetes with their descriptions:
Match the following chronic complications of diabetes with their descriptions:
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What is the most common cause of chronic kidney insufficiency?
What is the most common cause of chronic kidney insufficiency?
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Acute renal failure can be caused solely by prerenal mechanisms.
Acute renal failure can be caused solely by prerenal mechanisms.
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What is hydronephrosis?
What is hydronephrosis?
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Which of the following is NOT a manifestation of acute bladder inflammation?
Which of the following is NOT a manifestation of acute bladder inflammation?
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Vesicoureteral reflux can lead to kidney damage and infections.
Vesicoureteral reflux can lead to kidney damage and infections.
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What is a polyp?
What is a polyp?
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The acidic contents of the stomach can flow back into the esophagus due to a _______ lower esophageal sphincter.
The acidic contents of the stomach can flow back into the esophagus due to a _______ lower esophageal sphincter.
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Match the following mechanisms of diarrhea with their descriptions:
Match the following mechanisms of diarrhea with their descriptions:
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What risk factors are associated with developing urolithiasis?
What risk factors are associated with developing urolithiasis?
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Chronic pancreatitis involves transient inflammation without any fibrosis.
Chronic pancreatitis involves transient inflammation without any fibrosis.
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A hiatal hernia is the dislocation of part of the stomach through the esophageal _______.
A hiatal hernia is the dislocation of part of the stomach through the esophageal _______.
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Study Notes
Pathological Anatomy and Physiology
- Pathological anatomy studies structural changes caused by disease in tissues and organs.
- Pathological physiology examines the functional changes in the body during disease.
- Etiology refers to the cause of a disease.
- Pathogenesis describes the mechanism of disease development.
Types of Autopsies
- Clinical autopsies analyze the cause of a patient's death.
- Forensic autopsies investigate suspicious deaths.
- Anatomical autopsies are for research and education.
Biopsy and Cytology
- Biopsy involves the removal and examination of a tissue sample from a living patient.
- Cytology examines cells from swabs or liquids (excluding blood).
Molecular Pathological Examination
- Detects genetic changes in tumor cells, used for diagnosis and predicting disease progression.
Stages of Dying
- Clinical death is reversible.
- Biological death is irreversible.
Brain Death Diagnosis
- Diagnosed by clinical assessment (absence of brainstem reflexes, breathing, and electrical activity).
- Confirmatory testing includes cerebral angiography and brain perfusion scintigraphy.
Adaptation
- Adaptation is a reversible change in function and structure in response to increased or decreased demands on the organism.
- Types: hypertrophy, hyperplasia, atrophy, and metaplasia.
Hypertrophy vs. Hyperplasia
- Hypertrophy is an increase in the size of cells.
- Hyperplasia is an increase in the number of cells.
Atrophy
- A decrease in cell size or volume. Examples include brain and testicular atrophy.
Metaplasia
- Replacement of one type of differentiated cell with another.
Cell Death Types
- Necrosis is uncontrolled cell death.
- Apoptosis is regulated, programmed cell death.
Infarction
- Tissue death due to lack of blood supply.
Gangrene
- Necrosis modified by secondary changes, such as drying, infection by bacteria.
Pressure Ulcer
- Necrosis of skin and subcutaneous tissue due to prolonged pressure, often over bony areas in immobile patients.
Thrombosis
- Intravital clot formation in blood vessels. Factors contributing are endothelial injury, blood flow disorders, and the hypercoagulable state.
Embolism
- A substance (embolus) that travels through the bloodstream and blocks a vessel.
- Common types: thromboembolism, air embolism, fat embolism, amniotic fluid embolism, and tumor embolism.
Edema
- Accumulation of fluid in tissues due to mechanisms such as venous stasis, hypoproteinemia, sodium and water retention, and lymphedema.
Dehydration Signs
- Reduced fluid intake, diarrhea, vomiting, sweating, urine loss, fluid loss from burns.
Marfan Syndrome
- Genetic disorder affecting connective tissue (fibrillin gene), leading to tall stature, aortic defects, hypermobility, and flat feet and long limbs.
Amyloid/Amyloidosis
- A disease where soluble proteins convert into insoluble proteins that accumulate in tissues.
- Key role in Alzheimer's disease.
Skin Pigmentation Disorders
- Albinism, vitiligo, and freckles.
Lithiasis
- Presence of concrements in excretory systems.
Colic
- Sudden, intermittent pain from muscle contractions in excretory pathways.
Inflammation
- Defensive and reparative response to tissue damage, a part of the innate immune system.
- Local manifestations include rubor, dolor, calor, tumor, and functio laesa.
- Systemic manifestations include leukocytosis, leukopenia, increased acute-phase proteins, increased coagulation, sedimentation and fever.
Abscess vs. Phlegmon
- Abscess involves a localized collection of pus.
- Phlegmon is diffuse tissue inflammation.
Healing Types
- Regeneration is healing of a lesion, maintaining original tissue function.
- Reparation is healing of a lesion with a fibrous scar.
Fracture Healing
- Fracture healing involves hematoma formation, granulation tissue formation, cartilage callus formation, bone callus formation, and bone callus remodeling.
Immunity
- Innate immunity (general defense, no memory) and adaptive immunity (memory, involves T and B cells, specific immunity) protect against pathogens.
Low Immune System Activity
- Immunodeficiency diseases, immunosuppressive treatments, malnutrition and congenital or acquired immune system deficiencies.
Exaggerated Immune Reactions
- Allergies, and autoimmune diseases (e.g. rheumatoid arthritis, lupus).
Trisomy
- A genetic condition where a chromosome has three copies instead of two. Example: Down syndrome (trisomy 21).
Teratogen
- An external factor that can cause developmental disorders, such as alcohol or medications.
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Description
Test your knowledge on pathological anatomy and physiology, exploring structural and functional changes caused by diseases. Learn about different types of autopsies, biopsy procedures, and the stages of dying. This quiz covers critical concepts essential for understanding disease mechanisms and diagnostics.