Pathogenic Microorganisms Quiz
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Questions and Answers

Which pathogen is associated with dysentery and produces shiga toxin?

  • Bacillus cereus
  • Salmonella enterica
  • Shigella species (correct)
  • Clostridium difficile

What is the primary symptom of gastroenteritis caused by certain pathogens?

  • Severe abdominal pain
  • Mucosal abscesses
  • Bloody stools
  • Nausea, vomiting, and diarrhea (correct)

Which pathogen is primarily known for causing antibiotic-associated colitis?

  • Clostridium difficile (correct)
  • Yersinia
  • E.coli
  • Campylobacter jejuni

What is the role of M cells in the infection process of Shigella?

<p>They facilitate the entrance of pathogens into epithelial cells. (A)</p> Signup and view all the answers

What is a potential consequence of consuming food contaminated with Staphylococcus aureus?

<p>Immediate nausea and vomiting (B)</p> Signup and view all the answers

Which symptom is NOT associated with Clostridium difficile infections?

<p>Nausea and vomiting (D)</p> Signup and view all the answers

What characteristic is unique to the pathogenic process of Shigella compared to other gastrointestinal pathogens?

<p>It forms mucosal abscesses. (D)</p> Signup and view all the answers

What does virulence refer to in the context of pathogenic microorganisms?

<p>The extent of pathogenicity of an organism (A)</p> Signup and view all the answers

Which of the following best defines pathogenicity?

<p>The ability to cause disease in a host organism (A)</p> Signup and view all the answers

What role do beneficial microorganisms play within the human body?

<p>They prevent the overgrowth of pathogenic microbes. (A)</p> Signup and view all the answers

What is the significance of virulence factors in pathogens?

<p>They are responsible for increasing the pathogenicity of organisms. (B)</p> Signup and view all the answers

In terms of disease development, what does the term pathogenesis imply?

<p>The process through which disease develops (C)</p> Signup and view all the answers

Which of these terms refers to the infectious agent that causes Acquired Immunodeficiency Syndrome?

<p>Human Immunodeficiency Virus (B)</p> Signup and view all the answers

What defines the role of ATP in microbial physiology?

<p>It serves as the primary energy currency in cells. (C)</p> Signup and view all the answers

Which of the following terms is associated with non-infectious neurological diseases?

<p>Transmissible Spongiform Encephalopathy (A)</p> Signup and view all the answers

What is the primary pathogen associated with the most common cause of sepsis?

<p>Staphylococcus aureus (A)</p> Signup and view all the answers

Which antibiotic would be ineffective against E. coli in the treatment of sepsis?

<p>Vancomycin (D)</p> Signup and view all the answers

What is the treatment duration for osteomyelitis caused by Staphylococcus aureus?

<p>6 weeks (C)</p> Signup and view all the answers

Which of the following pathogens is NOT associated with gangrene?

<p>Staphylococcus aureus (A)</p> Signup and view all the answers

Which complication arises from a nosocomial infection of the uterus after childbirth?

<p>Puerperal sepsis (B)</p> Signup and view all the answers

What is the key feature of bacterial biofilms associated with prosthetic infections?

<p>Formation of a protective barrier (C)</p> Signup and view all the answers

Which treatment modality is recommended to prevent clostridia growth in gangrene?

<p>Hyperbaric chamber therapy (C)</p> Signup and view all the answers

In joint infections, what is the primary treatment approach aside from antibiotics?

<p>Drainage from the joint (B)</p> Signup and view all the answers

What defines septic shock in the context of sepsis?

<p>Blood pressure unresponsive to fluids (B)</p> Signup and view all the answers

Which Gram-negative bacterium is specifically noted as a cause of septic shock?

<p>Escherichia coli (A)</p> Signup and view all the answers

What primary feature distinguishes prokaryotes from eukaryotes?

<p>Lack of membrane-bound organelles (B)</p> Signup and view all the answers

Which component of the bacterial cell wall is primarily composed of alcohols and phosphates?

<p>Teichoic acids (A)</p> Signup and view all the answers

What is the primary function of the plasma (cytoplasmic) membrane in bacteria?

<p>Regulation of substance entry and exit (B)</p> Signup and view all the answers

Which statement about innate immunity is accurate?

<p>It is a rapid response from birth. (B)</p> Signup and view all the answers

What occurs during binary fission in prokaryotes?

<p>A single bacterium divides into two equal cells. (C)</p> Signup and view all the answers

Which of the following best describes a semirigid structure in bacterial cells?

<p>Cell wall (D)</p> Signup and view all the answers

What is a primary component of lipopolysaccharides (LPS) in bacteria?

<p>Lipid A (B)</p> Signup and view all the answers

What characteristic is NOT associated with adaptive immunity?

<p>Generalized defense mechanism (A)</p> Signup and view all the answers

What primarily composes the plasma (cytoplasmic) membrane of prokaryotic cells?

<p>Phospholipids, carbohydrates, and proteins (A)</p> Signup and view all the answers

Why is the cell wall crucial for bacterial survival in various environments?

<p>It helps maintain osmotic balance. (B)</p> Signup and view all the answers

Which type of bacteria can grow in the presence of O2 but does not require it for survival?

<p>Facultative anaerobe (C)</p> Signup and view all the answers

What type of microbe thrives at low concentrations of O2?

<p>Microaerophile (B)</p> Signup and view all the answers

Which group of bacteria does NOT require O2 for survival and is not impacted by its presence?

<p>Aerotolerant anaerobe (C)</p> Signup and view all the answers

What is the main feature that distinguishes coagulase-positive Staphylococcus aureus from coagulase-negative species?

<p>Coagulation of fibrinogen (D)</p> Signup and view all the answers

What is the characteristic effect of β-hemolytic bacteria in hemolytic tests?

<p>Clear zone around colonies (D)</p> Signup and view all the answers

Which microbial characteristic is identified by acid-fast staining methods?

<p>Presence of mycolic acid (A)</p> Signup and view all the answers

Which of the following accurately describes an obligate aerobe?

<p>Requires O2 for growth (A)</p> Signup and view all the answers

Rickettsia, an atypical bacterium, is classified as which of the following?

<p>Obligate intracellular bacterium (D)</p> Signup and view all the answers

Which type of bacteria grows optimally in environments with elevated CO2 levels?

<p>Capnophile (C)</p> Signup and view all the answers

The presence of which type of bacteria would likely be indicated by greening on blood agar plates?

<p>α-hemolytic bacteria (B)</p> Signup and view all the answers

Flashcards

Pathogenicity

The ability of a microbe to cause disease in a host organism.

Pathogenesis

The process by which a disease develops in a host, including the microbe's entry and progression.

Virulence

The degree or extent of a pathogen's ability to cause disease; higher virulence = stronger pathogen.

Virulence factors

Features of a pathogen that contribute to its ability to cause disease, like capsules, cell wall components, and enzymes.

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Host response

Microbial communities naturally residing in the body, preventing harmful microbes from overgrowing and providing benefits.

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Transmission

The process of a disease spreading from one individual to another.

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Direct transmission

Refers to things like coughing, sneezing, or touching contaminated surfaces, spreading pathogens.

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Indirect transmission

Refers to things like contaminated water, food, or insects, spreading pathogens.

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Innate Immunity

The body's natural, non-specific defense system that's active from birth. It acts swiftly against infections without recognizing specific invaders and doesn't develop memory.

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Adaptive Immunity

The body's specific defense system that learns to recognize and target specific microbes. It takes time to develop but remembers past encounters.

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Prokaryotes

Single-celled organisms lacking a nucleus, with a peptidoglycan cell wall. They reproduce by binary fission, splitting into two identical cells.

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Bacterial Cell Wall

A complex, semi-rigid outer layer that surrounds the bacterial cell, providing structural support and protection.

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Plasma (Cytoplasmic) Membrane

The thin inner membrane enclosing the bacterial cytoplasm. It acts like a barrier, controlling what enters and leaves the cell, and contains enzymes for metabolic reactions.

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Teichoic Acids

A unique molecule found primarily in the bacterial cell wall, consisting of alcohols and phosphates.

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Lipopolysaccharides (LPS)

Complex molecules found in the outer membrane of Gram-negative bacteria. They consist of lipids and sugars, and lipid A is a powerful toxin.

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Lipid A (Endotoxin)

A powerful toxin found in the outer membrane of Gram-negative bacteria, part of LPS.

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Binary Fission

The process by which a bacterium divides into two identical daughter cells.

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Mesosomes

Irregular infoldings of the bacterial plasma membrane, often caused by specimen preparation, increasing surface area for metabolic activity.

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Obligate aerobe

Require oxygen (O2) for growth.

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Facultative anaerobe

Can grow with or without oxygen (O2), preferring O2.

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Microaerophile

Requires low levels of oxygen (O2) for growth.

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Capnophile

Grows best in high carbon dioxide (CO2) concentrations.

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Aerotolerant anaerobe

Oxygen (O2) is not required for survival nor growth.

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Obligate anaerobe

Grows only in the absence of oxygen (O2).

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Coagulase test

A test that detects coagulase, an enzyme produced by bacteria.

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Coagulase

An enzyme that coagulates (clot) fibrinogen in blood.

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Catalase test

A test that detects the presence of catalase, an enzyme that breaks down hydrogen peroxide.

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Catalase

An enzyme that breaks down hydrogen peroxide.

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Osteomyelitis

Inflammation of bone due to infection by bacteria like Staph aureus or gram-negative bacteria.

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Arthritis

Inflammation of a joint caused by bacterial infection, most commonly Staph aureus.

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Prostheses infection

Infection in artificial body parts like prostheses, often caused by bacterial biofilms.

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Sepsis

A systemic inflammatory response syndrome caused by pathogenic microorganisms or their toxins in the blood.

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Septic shock

A severe form of sepsis where blood pressure drops and cannot be recovered by fluid addition.

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Puerperal infection

A gram-positive infection of the uterus after childbirth or abortion, typically caused by haemolytic streptococci.

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Gangrene

Death of soft tissue due to loss of blood supply, often caused by bacteria like Clostridium.

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Gangrene: Clostridium role

A condition characterized by ischemia, necrosis, and toxin production by Clostridium bacteria.

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Gangrene Treatment

Treatment for gangrene involves hyperbaric chamber therapy, surgical removal of necrotic tissue, and antibiotics.

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Sepsis treatment: antibiotics

Antibiotics like Vancomycin, Ceftriaxone, Piperacillin-tazobactam, Ciprofloxacin, and Gentamicin are used in combination to treat sepsis.

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Food poisoning

A type of food poisoning caused by bacteria such as Staphylococcus aureus, Salmonella enterica, and Clostridium perfringens. It occurs when food contaminated with these bacteria is ingested, leading to symptoms such as nausea, vomiting, and diarrhea.

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Gastroenteritis

Inflammation of the gastrointestinal tract, often caused by bacteria like Salmonella enterica, E.coli, Yersinia, and Bacillus cereus. Symptoms include nausea, diarrhea, abdominal pain, and sometimes fever.

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Antibiotic associated colitis

A serious intestinal infection caused by Clostridium difficile bacteria. It often occurs after prolonged antibiotic use, disrupting the balance of gut bacteria. Symptomatic features include diarrhea, abdominal pain, and bloody stools.

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Dysentery

A severe form of diarrhea characterized by blood and mucus in the stool. It is caused by Shigella species, which produce toxins that damage the intestinal lining.

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M cells

These are specialized epithelial cells that line the intestinal tract and are part of the mucosal- and gut-associated lymphoid tissues (MALT and GALT). They are involved in immune responses and can be targeted by pathogens like Shigella.

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Shigella infection process

The process of bacterial invasion and infection in the gut. It involves attachment to intestinal cells, entry into cells, multiplication, spreading to neighboring cells, and immune system evasion.

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Shiga toxins

Shigella produces toxins called shiga toxins, which are responsible for the severe symptoms of dysentery. These toxins damage the intestinal lining and can cause bloody diarrhea and other complications.

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Study Notes

Medical Microbiology Legend

  • ACUTE: A rapidly occurring disease or condition.
  • AIDS: Acquired Immunodeficiency Syndrome
  • ANTIBIOTICS: Medication that fights bacteria.
  • ANTIBODY: Proteins that your body produces to fight off harmful substances.
  • ARTHROPODS: Category of invertebrate animals.
  • BACTERIAL: Relating to bacteria.
  • BACTERIA: Single-celled microorganisms.
  • BIOLOGICAL: Relating to the science of living organisms.
  • BLOOD: Fluid in the body carrying oxygen and nutrients.
  • CELL: The basic structural and functional unit of living organisms.
  • CHILLS: A symptom characterized by shivering.
  • CHRONIC: Long-lasting disease or condition.
  • COMBINATION: Mixture or blend of substances or factors.
  • DISEASE: Illness or disorder of the body (or mind).
  • DRUG: Medications or substances used to cure or treat illnesses.
  • DNA: Deoxyribonucleic acid, chemical substance in all living organisms responsible for reproduction and development.
  • ENDOTOXIN: Toxic components of bacterial cell walls.
  • ENZYME: A biological catalyst, protein promoting specific chemical reactions.
  • EPIDEMIOLOGICAL: Study of the causes, patterns, and control of diseases or injuries in a population.
  • EXOTOXIN: Toxins released by bacteria into the environment.
  • FUNGI: A large group of eukaryotic organisms.
  • GENOME: Complete set of genetic material of an organism.
  • GENUS: A classification of living organisms.
  • GRAM-POSITIVE: Type of bacteria.
  • GRAM-NEGATIVE: Type of bacteria.
  • GROWTH: Increase in size of an organism or biological entities.
  • HEALTH: State of complete physical, mental and social well-being and not merely the absence of disease or infirmity.
  • HOST: Living being in which a parasite or pathogen grows.
  • IMMUNE: Body's ability to protect itself from disease.
  • INFECTION: State caused by the entrance and multiplication of microorganisms in body.
  • INFECTION PROCESS: Steps from invasion to harm.
  • INFLAMMATION: Body's response to damage or injury.
  • IMMUNOLOGY: Study of the immune system.
  • LOG PHASE: Rapid growth phase of microbial populations.
  • LPS: Lipopolysaccharide.
  • MALARIA: A parasitic disease transmitted through mosquito bites.
  • MEMBRANE: Layer that surrounds a cell or organelle.
  • METABOLISM: Metabolic reaction or conversion in body.
  • MICROORGANISM: A tiny living structure.
  • MOLECULAR: Relating to the structure and interactions of molecules.
  • MOLECULES: Groups of atoms bonded together.
  • MUMPS: Viral disease characterized by inflammation of the salivary glands.
  • NEUROLOGY: Study of the nervous system.
  • NEUROPATHOLOGY: The study of diseases affecting the nervous system.
  • NUCLEUS: Organelle that contains the genetic material of a cell.
  • ORGANELLES: Specialized compartments within a cell.
  • PATHOGEN: Organism capable of causing disease.
  • PATHOGENESIS: Development of a disease.
  • PATHOLOGY: Study of diseases and their causes.
  • PHARMACOLOGY: Study of drugs and medicines.
  • PHYSIOLOGY: Study of how the body works.
  • PRION: Infectious protein.
  • RNA: Ribonucleic acid, molecule involved in gene expression.
  • RNA VIRUSES: Viruses whose genetics are composed of RNA.
  • RESPIRATORY: Relating to the respiratory system.
  • RNA VIRUS: Virus with ribonucleic acid.
  • SEPTUM: Thin wall forming a division in a cell.
  • STEROID: Any of a group of organic compounds.
  • VIRULENCE: Degree of pathogenicity.
  • VIRUS: A small infectious agent that replicates itself only inside the living cells.
  • WASTE PRODUCTS: Substances eliminated as part of metabolism.

Definitions

  • Pathogenicity: Ability to cause disease in a host.
  • Pathogenesis: Process by which a disease develops.
  • Virulence: Degree of pathogenicity; higher factors are more damaging.
  • Host response: Body's reactions to microorganisms (harmful or not).
  • Innate immunity: Protection existing from birth, rapid defense.
  • Adaptive immunity: Immunity developed over time, provides memory of encounter.

Prokaryotes

  • Prokaryotes are single-celled organisms without membrane-bound organelles.
  • They reproduce by binary fission.
  • Their cell walls contain peptidoglycan.

Bacterial Structural Features

  • Cell wall: A complex structural layer outside the plasma membrane.
  • Plasma membrane: The thin membrane surrounding the cytoplasm.
  • Mesosomes: Irregular infoldings in the plasma membrane.

Cell Wall

  • Teichoic acids are primarily composed of alcohols and phosphates.
  • Gram-negative bacteria's cell walls contain lipopolysaccharides.

Exotoxin Diseases

  • Various types from diverse bacteria cause diverse symptoms.

Endotoxin and Exotoxin

  • Bacterial source: Endotoxins mainly from Gram-negative; Exotoxins from mainly Gram-positive but may be Gram-negative.
  • Stability: Endotoxins are stable; Exotoxins are unstable.
  • Toxicity: Endotoxins have a low toxicity level, while exotoxins are highly toxic.

Bacterial Growth Phases

  • Lag phase: Little change in cell numbers because cells are not immediately reproducing.
  • Log phase: Logarithmic increase in cell numbers, highly active reproduction.
  • Stationary phase: Growth rate slows, where deaths balance new cells.
  • Death phase: Number of deaths surpass the number of new cells.

Oxygen Requirements

  • Obligate aerobe: Requires oxygen to grow.
  • Facultative anaerobe: Can grow with or without oxygen.
  • Microaerophile: Requires low oxygen levels.
  • Capnophile: Requires high carbon dioxide levels.
  • Aerotolerant anaerobe: Can tolerate oxygen but doesn't require it to grow.
  • Obligate anaerobe: Cannot grow in the presence of oxygen.

Bacterial Identification

  • Coagulase: Test for clotting factors to identify specific types.
  • Catalase: Test to identify if bacteria produces this enzyme.
  • Hemolytic: Test to examine the ability of bacteria to break down red blood cells.
  • Acid-fast: Stains bacteria based on the presence of waxy lipid in cell walls.
  • Atypical bacteria: Obligate intracellular bacteria transmitted by bites requiring specific antibiotics.

Antibiotics Coverage Chart Summary

  • Details on Gram-positive cocci, Gram-negative bacilli, Gram-negative cocci, anaerobes, and atypicals are shown.
  • Charts describe various antibiotics based on sensitivities and types.

Hospital Epidemiology

  • Epidemiology: Study of distribution, determinants of health, and disease in a specific population.
  • Infection types: Hospital-acquired infections.
  • Pathogens: Various bacterial species, including staphylococcus, enterococci, E. coli, pseudomonas, and other types.

Viral Infections: Hepatitis Types

  • Transmission types: Ingested, Parenteral.
  • Treatment methods for Hepatitis B, C etc.

Fetal, Newborn and Infant Infections

  • Transmission types are through the placenta and breastmilk.
  • Treatment types for various conditions.

Skin Infections

  • Types of infections, viral and non-viral, for specific skin parts.
  • Transmission and treatment methods

Yellow Fever

  • Caused by the flavivirus and transmitted via mosquito.
  • Stages show similar symptoms typical for fever conditions.

Infectious Mononucleosis

  • Caused by Epstein-Barr virus.
  • Symptoms may include fever, sore throat, swollen lymph nodes.
  • Recovery usually takes a few weeks.

Viral Infections

  • Conjunctivitis: inflammation of the conjunctiva.
  • Keratoconjunctivitis: inflammation of the conjunctiva and cornea.

Antifungal Agents

  • Specific types of antifungal agents targeting different aspects of fungal biology.
  • MOAL: Mechanism of Action in Listeria.

Protozoan Diseases

  • Protozoa are single-celled eukaryotic organisms.
  • Various pathogens, classifications, and disease types.

Ectoparasites

  • Classifications based on class, types, diseases, and related species.

Mycology

  • Mycology is the study of fungi.
  • Characteristics, species in various classifications are seen and identified.

Aspergillus

  • Fungal infection affecting those that are compromised.
  • Infection types, transmission, and treatment details.

Histoplasmosis

  • Details on transmission types, infection location, and treatment options.

Blastomycosis

  • Infection type, symptoms, soil reservoir types, and treatment types.

Coccidioidomycosis

  • Fungal respiratory disease with airborne reproduction, symptoms, and treatment details.

Cryptococcosis, Dermatophytes

  • Cryptococcus neoformans meningitis is detailed with known pathogens.
  • Dermatophytes and their infections like ringworm are included.

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Description

Test your knowledge on various pathogens and their roles in gastroenteritis and dysentery. This quiz covers symptoms, virulence factors, and the consequences of infections caused by specific microorganisms. Ideal for students studying microbiology or infectious diseases.

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