Pathogenesis of Acute Inflammation ILOs
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Questions and Answers

Which type of leukocyte is initially recruited in response to bacterial infections?

  • Monocytes
  • Neutrophils (correct)
  • Eosinophils
  • Lymphocytes

What type of leukocyte is predominantly recruited during the first 6 to 24 hours in response to necrosis?

  • Neutrophils (correct)
  • Eosinophils
  • Lymphocytes
  • Monocytes

Which leukocyte type is recruited in viral infections?

  • Neutrophils
  • Monocytes
  • Eosinophils
  • Lymphocytes (correct)

What is the predominant leukocyte recruited after 24 to 48 hours in response to necrosis?

<p>Monocytes (D)</p> Signup and view all the answers

Which type of reaction induces a mixed infiltrate of leukocytes?

<p>Hypersensitivity reactions (A)</p> Signup and view all the answers

What is the primary driving force for leukocyte movement after traversing the endothelium?

<p>Chemotactic agents (C)</p> Signup and view all the answers

What triggers the polymerization of actin at the leading edge of the cell and facilitates cell movement in the direction of the locally produced chemoattractant?

<p>Chemotactic agents (B)</p> Signup and view all the answers

Which molecule is responsible for mediating the firm adhesion between leukocytes and endothelium?

<p>Integrins (B)</p> Signup and view all the answers

What is the site at which there is maximal retraction of endothelial cells during extravasation of leukocytes?

<p>Postcapillary venules (A)</p> Signup and view all the answers

What is the primary mechanism by which leukocytes move after extending pseudopods?

<p>Binding the extracellular matrix (ECM) (D)</p> Signup and view all the answers

What is the predominant leukocyte recruited after 24 to 48 hours in response to necrosis?

<p>Monocytes</p> Signup and view all the answers

Which type of leukocyte is initially recruited in response to bacterial infections?

<p>Neutrophils</p> Signup and view all the answers

Which leukocyte type is recruited in viral infections?

<p>Lymphocytes</p> Signup and view all the answers

What type of leukocyte is predominantly recruited during the first 6 to 24 hours in response to necrosis?

<p>Neutrophils</p> Signup and view all the answers

Which molecule is responsible for mediating the firm adhesion between leukocytes and endothelium?

<p>Integrins</p> Signup and view all the answers

What is the process defined as locomotion along a chemical gradient?

<p>Chemotaxis</p> Signup and view all the answers

What are the two major adhesion molecule pairs involved in leukocyte rolling and adhesion to endothelium?

<p>Selectins and Integrins</p> Signup and view all the answers

What stimulates leukocytes to travel along a chemical gradient in extravascular tissues?

<p>Chemokines</p> Signup and view all the answers

Which leukocyte type undergoes apoptosis after 24 to 48 hours?

<p>Neutrophils</p> Signup and view all the answers

What is the primary mechanism by which leukocytes migrate through the vessel wall?

<p>Squeezing between cells at intercellular junctions</p> Signup and view all the answers

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