20 Questions
Which type of leukocyte is initially recruited in response to bacterial infections?
Neutrophils
What type of leukocyte is predominantly recruited during the first 6 to 24 hours in response to necrosis?
Neutrophils
Which leukocyte type is recruited in viral infections?
Lymphocytes
What is the predominant leukocyte recruited after 24 to 48 hours in response to necrosis?
Monocytes
Which type of reaction induces a mixed infiltrate of leukocytes?
Hypersensitivity reactions
What is the primary driving force for leukocyte movement after traversing the endothelium?
Chemotactic agents
What triggers the polymerization of actin at the leading edge of the cell and facilitates cell movement in the direction of the locally produced chemoattractant?
Chemotactic agents
Which molecule is responsible for mediating the firm adhesion between leukocytes and endothelium?
Integrins
What is the site at which there is maximal retraction of endothelial cells during extravasation of leukocytes?
Postcapillary venules
What is the primary mechanism by which leukocytes move after extending pseudopods?
Binding the extracellular matrix (ECM)
What is the predominant leukocyte recruited after 24 to 48 hours in response to necrosis?
Monocytes
Which type of leukocyte is initially recruited in response to bacterial infections?
Neutrophils
Which leukocyte type is recruited in viral infections?
Lymphocytes
What type of leukocyte is predominantly recruited during the first 6 to 24 hours in response to necrosis?
Neutrophils
Which molecule is responsible for mediating the firm adhesion between leukocytes and endothelium?
Integrins
What is the process defined as locomotion along a chemical gradient?
Chemotaxis
What are the two major adhesion molecule pairs involved in leukocyte rolling and adhesion to endothelium?
Selectins and Integrins
What stimulates leukocytes to travel along a chemical gradient in extravascular tissues?
Chemokines
Which leukocyte type undergoes apoptosis after 24 to 48 hours?
Neutrophils
What is the primary mechanism by which leukocytes migrate through the vessel wall?
Squeezing between cells at intercellular junctions
Test your understanding of the pathogenesis of acute inflammation with this quiz. Evaluate leukocyte recruitment, roles of neutrophils and macrophages, classification of acute inflammation types, and their correlation to clinical conditions.
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