Virulence Factors

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Questions and Answers

In order to survive, pathogens require a source of nutrients, protection from harmful elements and:

  • Dissemination through the oesophagus
  • Colonization of a niche in the host (correct)
  • Access to the vascular system
  • None of the above

Some enveloped viruses use antigenic variation which makes it difficult for the immune system to recognise different strains of the virus. Which type of antigenic variation results in a major change in spike proteins due to gene reassortment?

  • Antigenic drift
  • Antigenic shift (correct)
  • Antigenic draft
  • Antigenic shaft

Which pathogen type is always a member of the normal microbiota and only causes disease in an immunocompromised host?

  • Primary pathogen
  • Discreet pathogen
  • Opportunistic pathogen (correct)
  • Individual pathogen

Which type of pathogen is an environmental microbe that is able to cause disease in an otherwise healthy individual?

<p>Primary pathogen (A)</p> Signup and view all the answers

Virulence factors can be described as:

<p>All of the above (D)</p> Signup and view all the answers

What kind of virulence factors are proteases, nucleases, phospholipases and glycohydrolases?

<p>Exoenzymes (C)</p> Signup and view all the answers

Which of these virulence factors act as adhesins?

<p>All of the above (D)</p> Signup and view all the answers

Which of these virulence factors assist in promoting colonization of the host?

<p>Adhesins (B)</p> Signup and view all the answers

Which of these virulence factors enable damage to be caused to the host?

<p>Toxins and exoenzymes (B)</p> Signup and view all the answers

Which virulence factor does Porphyromonas Gingivalis use which leads to disregulated immunity in the gingival tissues and breakdown of the structures around the teeth?

<p>Fimbraie and exoenzyme Gingipains (A)</p> Signup and view all the answers

Flashcards

Pathogen survival requirements

A pathogen needs nutrients, protection, and the ability to establish itself within the host.

Antigenic shift

Major change in viral spike proteins due to gene reassortment, leading to new viral strains.

Opportunistic pathogen

Normal microbiota member that causes disease only in immunocompromised individuals.

Primary pathogen

An environmental microbe that can cause disease in a healthy individual.

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Virulence factors

Factors that enhance a pathogen's ability to cause disease.

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Exoenzymes

Virulence factors such as proteases, nucleases, phospholipases, and glycohydrolases.

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Adhesins

Surface molecules that facilitate pathogen attachment to host cells.

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Colonization via adhesins

Virulence factors such as adhesins that promote pathogen settlement within the host.

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Host damage virulence factors

Virulence factors such as toxins and exoenzymes.

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Porphyromonas gingivalis virulence factors

Fimbriae and exoenzyme Gingipains

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