19 Questions
Which protein triggers signaling pathways that activate IRFs and NF-κB?
MAVS
What is the function of C-Type Lectin Receptors (CLRs)?
Binding carbohydrates on pathogens and some allergens
What is the specific function of NOD-like Receptors (NLRs)?
Recognizing peptidoglycan from bacterial cell wall
Which family of receptor recognizes viral double-stranded RNAs and certain structured single-stranded RNA?
RIG-I-like Receptors (RLRs)
What is the role of CARD adaptor protein in PRR signaling pathways?
Activating IRF5 (transcription factor)
What process results in the activation of transcription factors which leads to gene expression?
Ubiquitination
What is the function of RIG-I-like Receptors (RLRs)?
Recognition of viral double-stranded RNAs
What type of receptors are RLR & NLR?
(PRRs) Intracellular only receptors
What does TLR bind to?
Pathogen-associated molecular patterns
What is the role of MAPK pathways in PRR signaling?
Triggering signaling cascades that activate AP-1 and NF-kB
What is the main function of NOD-like Receptors (NLRs)?
Trigger caspase-1 protease activation
Which molecular patterns support the lifestyle of pathogens?
Pathogen-Associated Molecular Patterns (PAMPs)
What is the role of Pattern Recognition Receptors (PRRs) in host cells?
Recognize Pathogen-Associated Molecular Patterns (PAMPs)
Which cells are MOST important to get activated among myeloid white blood cells and lymphoid cells?
T cells and B cells
Which type of cells have Pattern Recognition Receptors (PRRs) for recognizing Pathogen-Associated Molecular Patterns (PAMPs)?
All types of myeloid white blood cells and a subset of lymphoid cells
Where are Toll-like receptors (TLRs) located?
At different sites depending on the PAMP they recognize
What do different Toll-like receptors (TLRs) recruit when binding to Pathogen-Associated Molecular Patterns (PAMPs)?
Different adaptor proteins
Which signaling pathway is activated by Toll-like receptors (TLRs) when binding to Pathogen-Associated Molecular Patterns (PAMPs)?
NF-κB transcription factor activation
What is the key event that leads to the activation of Transcription Factors when Toll-like receptors (TLRs) bind to Pathogen-Associated Molecular Patterns (PAMPs)?
Phosphorylation
Test your knowledge about Pathogen-Associated Molecular Patterns (PAMPs) and Pattern Recognition Receptors (PRRs) and their role in host cells in recognizing pathogens and damage-associated molecular patterns (DAMPs).
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