Lecture 6 - PRRs and Signalling
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Questions and Answers

Which type of receptors bind carbohydrates on pathogens and trigger signaling cascades?

  • C-Type Lectin Receptors (CLRs) (correct)
  • TLR
  • NLRs
  • RLRs
  • Which receptors recognize viral double-stranded RNAs and certain structured single-stranded RNA?

  • NLRs
  • RLRs (correct)
  • TLR
  • CLRs
  • Which receptors recognize peptidoglycan from bacterial cell walls?

  • TLR
  • NLRs (correct)
  • RLRs
  • CLRs
  • Which proteins carry out post-translational modifications such as cleaving IL-1b/IL-18 into active forms for release?

    <p>Caspase-1</p> Signup and view all the answers

    Which process involves the attachment of ubiquitin to a target protein, often resulting in activation of transcription factors?

    <p>Ubiquitination</p> Signup and view all the answers

    Which pathway results in the activation of AP-1 and NF-kB transcription factors?

    <p>MAPK pathway</p> Signup and view all the answers

    Which protein activates IRF5, a transcription factor?

    <p>CARD adaptor protein</p> Signup and view all the answers

    Which receptors are always intracellular and recognize components that end up in the cytosol?

    <p>RLRs</p> Signup and view all the answers

    Which receptors primarily bind PAMPs?

    <p>TLR</p> Signup and view all the answers

    Which receptor is known to trigger signaling cascades involving MAPK pathways?

    <p>TLR</p> Signup and view all the answers

    Which type of molecular patterns are recognized by Pattern Recognition Receptors (PRRs) according to the text?

    <p>Pathogen-Associated Molecular Patterns (PAMPs)</p> Signup and view all the answers

    Which cells express Pattern Recognition Receptors (PRRs) according to the text?

    <p>All types of myeloid white blood cells</p> Signup and view all the answers

    Where are Pathogen-Associated Molecular Patterns (PAMPs) recognized by Pattern Recognition Receptors (PRRs) located?

    <p>Cell Surface</p> Signup and view all the answers

    What is a key event that leads to the activation of Transcription Factors according to the text?

    <p>Phosphorylation</p> Signup and view all the answers

    Which location helps determine what Pattern Recognition Receptors (PRRs) bind to according to the text?

    <p>Intracellular vs Extracellular</p> Signup and view all the answers

    Which molecules help form large signaling complexes once activated according to the text?

    <p>Adaptor proteins</p> Signup and view all the answers

    What type of cells have Pattern Recognition Receptors (PRRs) that can recognize both Pathogen-Associated Molecular Patterns (PAMPs) and Damage-associated Molecular Patterns (DAMPs)?

    <p>All types of myeloid white blood cells</p> Signup and view all the answers

    Where are Toll-like receptors (TLRs) specifically anchored within the cell?

    <p>Endosome</p> Signup and view all the answers

    Which receptors are expressed by most, if not all, cells in the body for detecting viral nucleic acids?

    <p>RIG-I-like receptors (RLRs)</p> Signup and view all the answers

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