Lecture 6 - PRRs and Signalling
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Questions and Answers

Which type of receptors bind carbohydrates on pathogens and trigger signaling cascades?

  • C-Type Lectin Receptors (CLRs) (correct)
  • TLR
  • NLRs
  • RLRs

Which receptors recognize viral double-stranded RNAs and certain structured single-stranded RNA?

  • NLRs
  • RLRs (correct)
  • TLR
  • CLRs

Which receptors recognize peptidoglycan from bacterial cell walls?

  • TLR
  • NLRs (correct)
  • RLRs
  • CLRs

Which proteins carry out post-translational modifications such as cleaving IL-1b/IL-18 into active forms for release?

<p>Caspase-1 (A)</p> Signup and view all the answers

Which process involves the attachment of ubiquitin to a target protein, often resulting in activation of transcription factors?

<p>Ubiquitination (A)</p> Signup and view all the answers

Which pathway results in the activation of AP-1 and NF-kB transcription factors?

<p>MAPK pathway (C)</p> Signup and view all the answers

Which protein activates IRF5, a transcription factor?

<p>CARD adaptor protein (D)</p> Signup and view all the answers

Which receptors are always intracellular and recognize components that end up in the cytosol?

<p>RLRs (B)</p> Signup and view all the answers

Which receptors primarily bind PAMPs?

<p>TLR (D)</p> Signup and view all the answers

Which receptor is known to trigger signaling cascades involving MAPK pathways?

<p>TLR (A)</p> Signup and view all the answers

Which type of molecular patterns are recognized by Pattern Recognition Receptors (PRRs) according to the text?

<p>Pathogen-Associated Molecular Patterns (PAMPs) (A)</p> Signup and view all the answers

Which cells express Pattern Recognition Receptors (PRRs) according to the text?

<p>All types of myeloid white blood cells (A)</p> Signup and view all the answers

Where are Pathogen-Associated Molecular Patterns (PAMPs) recognized by Pattern Recognition Receptors (PRRs) located?

<p>Cell Surface (A)</p> Signup and view all the answers

What is a key event that leads to the activation of Transcription Factors according to the text?

<p>Phosphorylation (C)</p> Signup and view all the answers

Which location helps determine what Pattern Recognition Receptors (PRRs) bind to according to the text?

<p>Intracellular vs Extracellular (D)</p> Signup and view all the answers

Which molecules help form large signaling complexes once activated according to the text?

<p>Adaptor proteins (B)</p> Signup and view all the answers

What type of cells have Pattern Recognition Receptors (PRRs) that can recognize both Pathogen-Associated Molecular Patterns (PAMPs) and Damage-associated Molecular Patterns (DAMPs)?

<p>All types of myeloid white blood cells (A)</p> Signup and view all the answers

Where are Toll-like receptors (TLRs) specifically anchored within the cell?

<p>Endosome (C)</p> Signup and view all the answers

Which receptors are expressed by most, if not all, cells in the body for detecting viral nucleic acids?

<p>RIG-I-like receptors (RLRs) (A)</p> Signup and view all the answers

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