COPY: PATH30190 & PATH30260 CTIII 11-12 DM Manifestations Quiz
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Questions and Answers

Which autoimmune disease is characterized by rough and cracked lateral and palmar areas of the fingers?

  • Systemic lupus erythematosus
  • Rheumatoid arthritis
  • Sjögren's syndrome
  • Dermatomyositis (correct)

What is a common systemic symptom associated with dermatomyositis?

  • Osteoporosis
  • Headaches
  • Arthralgia (correct)
  • Hypertension

Which antibody is specifically associated with dermatomyositis and presents with Gottron’s papules and heliotrope rash?

  • Anti-Sm antibodies
  • Anti-dsDNA antibodies
  • Anti-Ro antibodies
  • Anti-Jo1 antibodies (correct)

What is a distinguishing feature between dermatomyositis and polymyositis?

<p>Presence of skin rash (A)</p> Signup and view all the answers

Which characteristic of dermatomyositis is associated with anti-histidyl-tRNA-synthetase antibodies?

<p>Interstitial lung disease (D)</p> Signup and view all the answers

In dermatomyositis, where is the deposition of C5b-9 (MAC) commonly found?

<p>Capillary vessels (A)</p> Signup and view all the answers

What is the characteristic microscopic pathology of Henoch-Schonlein Purpura?

<p>Small vessel IgA mediated vasculitis (D)</p> Signup and view all the answers

Which symptom is NOT typically associated with Henoch-Schonlein Purpura?

<p>Nausea (A)</p> Signup and view all the answers

What is the common age group affected by Henoch-Schonlein Purpura?

<p>Young children (B)</p> Signup and view all the answers

Which antibody is typically elevated in p-ANCA (MPO-ANCA) associated vasculitides?

<p>IgA antibodies (D)</p> Signup and view all the answers

What type of vasculitis is characterized by skin lesions progressing from blanching macules to petechiae to palpable purpura in the buttocks and legs?

<p>Henoch-Schonlein Purpura (D)</p> Signup and view all the answers

What is the usual course of Henoch-Schonlein Purpura in terms of resolution?

<p>Resolves on its own without specific treatment (A)</p> Signup and view all the answers

What is the primary cause of systemic vasculitides?

<p>Autoimmune response targeting endothelial cells (A)</p> Signup and view all the answers

Which of the following is a general symptom of systemic vasculitides resulting from the inflammatory response?

<p>Fever (A)</p> Signup and view all the answers

What is the primary complication of giant cell arteritis (GCA) if left untreated?

<p>Blindness (D)</p> Signup and view all the answers

What is the recommended therapy for giant cell arteritis (GCA)?

<p>Steroids (A)</p> Signup and view all the answers

Which of the following is a characteristic finding in the histopathology of giant cell arteritis (GCA)?

<p>Multinucleated giant cells in the elastic lamina (C)</p> Signup and view all the answers

What is the primary mechanism by which systemic vasculitides lead to organ damage?

<p>Reduced blood flow and ischemia due to vessel damage (A)</p> Signup and view all the answers

Which of the following is a characteristic of Polymyalgia Rheumatica (PMR)?

<p>Sudden bilateral neck, shoulder and low back muscle pain and stiffness (B)</p> Signup and view all the answers

What is the prevalence of Polymyalgia Rheumatica (PMR) in people over 50 years old?

<p>1 in 133 (D)</p> Signup and view all the answers

Which of the following is a characteristic of Takayasu Arteritis?

<p>Granulomatous vasculitis mainly affecting the aorta and its branches (C)</p> Signup and view all the answers

Which of the following is a potential complication of Takayasu Arteritis?

<p>All of the above (D)</p> Signup and view all the answers

What is the characteristic histopathological finding in Polymyalgia Rheumatica (PMR)?

<p>CD4+ T-cell infiltrate (A)</p> Signup and view all the answers

Which of the following is a characteristic of Polyarteritis Nodosa?

<p>Segmental transmural necrotizing inflammation of small- to medium-sized arteries (A)</p> Signup and view all the answers

Which disease is characterized by fibrinoid necrosis of the arterial wall and thrombotic occlusion of the lumen?

<p>Kawasaki Disease (B)</p> Signup and view all the answers

What is the hallmark histological feature seen in Buerger's Disease?

<p>Segmental thrombosing vasculitis (C)</p> Signup and view all the answers

Which condition is NOT associated with ANCA antibodies?

<p>Kawasaki Disease (D)</p> Signup and view all the answers

Which disease predominantly affects young heavy smokers and may co-exist with Raynaud's phenomenon?

<p>Buerger's Disease (D)</p> Signup and view all the answers

Which disease is characterized by the classical triad of kidney involvement, nasopharyngeal ulcers, and lung nodular densities?

<p>Granulomatosis with Polyangiitis (B)</p> Signup and view all the answers

Which condition primarily affects vessels of the respiratory tract and is strongly associated with asthma and eosinophilia?

<p>Churg-Strauss Syndrome (D)</p> Signup and view all the answers

What is the classic symptom seen in Kawasaki Disease that spares the limbus?

<p>Conjunctivitis (C)</p> Signup and view all the answers

Which disease results in aneurysm and myocardial infarction if left untreated?

<p>Kawasaki Disease (D)</p> Signup and view all the answers

What is the main histological finding in Microscopic Polyangiitis?

<p>Necrotizing vasculitis (C)</p> Signup and view all the answers

What differentiates Churg-Strauss Syndrome from other small vessel vasculitides?

<p>Involvement of coronary arteries (D)</p> Signup and view all the answers

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