15 Questions
What is the main neuropathological feature of Parkinson's disease?
Progressive dopaminergic neuron death in substantia nigra
What is the estimated average disease duration of Parkinson's disease?
20 years
Which clinical triad is characteristic of Parkinson's disease?
Tremor at rest, muscle rigidity, bradykinesia
Which enzyme is responsible for metabolizing L-DOPA to dopamine in dopaminergic neurons?
Aromatic L-amino acid decarboxylase (AADC)
Which enzyme inhibitors are used to allow a higher percentage of L-DOPA to reach the central nervous system?
Entacapone and Benserazide
Which formulation of L-DOPA is administered via percutaneous endoscopic gastrostomy in advanced stages of Parkinson's disease?
Duo-DOPA
Which of the following is a side effect associated with dopamine agonists used in the treatment of Parkinson's disease?
Reversible cardiac fibrosis
Which stage of L-DOPA administration is characterized by the development of hyperkinesia/dyskinesias and lack of response?
Late-stage (6 – 10 years)
Which type of dopamine agonists are normally used in early stages of Parkinson's disease to limit the total dopamine dose and prevent dyskinesias?
Non-ergot-derived
What is the purpose of using Rytary, a formulation of L-DOPA, in the treatment of Parkinson's disease?
To provide immediate and slow-release L-DOPA with carbidopa
Which side effect is specifically associated with dopamine agonists used in the treatment of Parkinson's disease?
Excessive daytime sleepiness
What is a potential issue with dopamine agonists and L-DOPA in Parkinson's disease treatment?
Activation of the reward center leading to addiction
Which medication is administered via injection in the treatment of Parkinson's disease?
Apomorphine
What is a potential contraindication for dopamine agonists in Parkinson's disease treatment?
DA antagonists (antipsychotics, anti-emetics)
Why is early diagnosis important in finding a cure for Parkinson's disease?
To identify tractable targets
Test your knowledge of Parkinson's disease with this quiz. Explore key facts about this progressive neurodegenerative movement disorder, its clinical triad, risk factors, and impact on individuals and society.
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