26 Questions
What is the role of MPTP in parkinsonian disorders?
Induces a form of parkinsonism in humans
Which of the following is NOT a risk factor associated with Parkinson’s disease?
Smoking
What is the significance of age in the development of Parkinson’s disease?
Most people with Parkinson's first develop the disease at about age 60
What is the gender difference in the incidence of Parkinson’s disease?
1.5 times more common in males than in females
How does pesticide exposure affect the risk of developing Parkinson’s disease?
Increases the risk by 70%
In what way did the 23-year-old college student’s case contribute to understanding Parkinsonian disorders?
Revealed the role of MPTP in parkinsonian disorders
Which enzyme is responsible for the decarboxylation of levodopa to dopamine?
Amino acid decarboxylase
What is the main neurotransmitter implicated in Parkinson's disease?
Dopamine
Which neurotransmitter is responsible for muscle relaxation?
Dopamine
What is the cytotoxic byproduct generated by the Haber-Weiss reaction involving hydrogen peroxide and superoxide?
Hydroxy radical
Which drug inhibits the COMT-based metabolism of levodopa?
Entacapone
What role do dopamine agonists like bromocriptine and amantadine play in Parkinson's disease pharmacotherapy?
Promote dopamine effect in the brain
What is the primary function of anti-cholinergic drugs like atropine and benzhexol in treating Parkinson's disease?
Reduce acetylcholine effects
In Parkinson's disease, what occurs due to the reduction of acetylcholine levels?
Motor disorders
What is the primary neurotransmitter that undergoes MAO-catalyzed oxidation in Parkinson's disease?
Dopamine
How does L-Dopa cross the blood-brain barrier to increase dopamine concentrations in the brain?
Through active transport via amino acid transporter
What is the purpose of co-administering carbidopa with levodopa?
To block the conversion of levodopa to dopamine in the periphery
Which enzyme is specifically blocked by entacapone to allow more levodopa to penetrate the brain?
Catechol-O-methyl transferase
How do MAO-B inhibitors affect the duration of response to levodopa?
Extend it
Which enzyme is primarily targeted by Tolcapone and entacapone?
Catechol-O-methyl transferase
What neurotransmitter is primarily impacted by Amantadine in Parkinson's disease treatment?
Dopamine
What is the main role of Selegiline and rasagiline in Parkinson's disease treatment?
Inhibit monoamine oxidase-B outside the brain
Why is Levodopa given in combination with carbidopa?
To facilitate Levodopa's entry into the brain
What is the primary function of Entacapone in Parkinson's disease therapy?
Inhibit enzymes that degrade Levodopa in the brain
How do Tolcapone and entacapone affect dopamine levels in the brain?
Prolong dopamine activity by blocking its reuptake
What role does Amantadine play in Parkinson's disease treatment?
Promote dopamine release from storage sites
Explore the causes, risk factors, and treatment options for Parkinson's disease in this quiz on Medicinal Chemistry by Dr. M Casely-Hayford. Learn about the role of MPTP, levodopa biosynthesis, metabolism, and different classes of drugs used to manage Parkinson's disease.
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