Parkinson's Disease Medicinal Chemistry Quiz
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Questions and Answers

What is the role of MPTP in parkinsonian disorders?

  • Inhibits the formation of cytotoxic chemical species
  • Induces a form of parkinsonism in humans (correct)
  • Prevents the degeneration of dopaminergic neurons
  • Enhances the biosynthesis of levodopa

    • Which of the following is NOT a risk factor associated with Parkinson’s disease?

  • Gender
  • Smoking (correct)
  • Pesticide exposure
  • Age

    • What is the significance of age in the development of Parkinson’s disease?

  • It has no impact on the onset of Parkinson's disease
  • Most people with Parkinson's first develop the disease at about age 60 (correct)
  • It decreases the risk of developing Parkinson's disease
  • It increases the risk of developing Parkinson's disease

    • What is the gender difference in the incidence of Parkinson’s disease?

    <p>1.5 times more common in males than in females</p> Signup and view all the answers

    How does pesticide exposure affect the risk of developing Parkinson’s disease?

    <p>Increases the risk by 70%</p> Signup and view all the answers

    In what way did the 23-year-old college student’s case contribute to understanding Parkinsonian disorders?

    <p>Revealed the role of MPTP in parkinsonian disorders</p> Signup and view all the answers

    Which enzyme is responsible for the decarboxylation of levodopa to dopamine?

    <p>Amino acid decarboxylase</p> Signup and view all the answers

    What is the main neurotransmitter implicated in Parkinson's disease?

    <p>Dopamine</p> Signup and view all the answers

    Which neurotransmitter is responsible for muscle relaxation?

    <p>Dopamine</p> Signup and view all the answers

    What is the cytotoxic byproduct generated by the Haber-Weiss reaction involving hydrogen peroxide and superoxide?

    <p>Hydroxy radical</p> Signup and view all the answers

    Which drug inhibits the COMT-based metabolism of levodopa?

    <p>Entacapone</p> Signup and view all the answers

    What role do dopamine agonists like bromocriptine and amantadine play in Parkinson's disease pharmacotherapy?

    <p>Promote dopamine effect in the brain</p> Signup and view all the answers

    What is the primary function of anti-cholinergic drugs like atropine and benzhexol in treating Parkinson's disease?

    <p>Reduce acetylcholine effects</p> Signup and view all the answers

    In Parkinson's disease, what occurs due to the reduction of acetylcholine levels?

    <p>Motor disorders</p> Signup and view all the answers

    What is the primary neurotransmitter that undergoes MAO-catalyzed oxidation in Parkinson's disease?

    <p>Dopamine</p> Signup and view all the answers

    How does L-Dopa cross the blood-brain barrier to increase dopamine concentrations in the brain?

    <p>Through active transport via amino acid transporter</p> Signup and view all the answers

    What is the purpose of co-administering carbidopa with levodopa?

    <p>To block the conversion of levodopa to dopamine in the periphery</p> Signup and view all the answers

    Which enzyme is specifically blocked by entacapone to allow more levodopa to penetrate the brain?

    <p>Catechol-O-methyl transferase</p> Signup and view all the answers

    How do MAO-B inhibitors affect the duration of response to levodopa?

    <p>Extend it</p> Signup and view all the answers

    Which enzyme is primarily targeted by Tolcapone and entacapone?

    <p>Catechol-O-methyl transferase</p> Signup and view all the answers

    What neurotransmitter is primarily impacted by Amantadine in Parkinson's disease treatment?

    <p>Dopamine</p> Signup and view all the answers

    What is the main role of Selegiline and rasagiline in Parkinson's disease treatment?

    <p>Inhibit monoamine oxidase-B outside the brain</p> Signup and view all the answers

    Why is Levodopa given in combination with carbidopa?

    <p>To facilitate Levodopa's entry into the brain</p> Signup and view all the answers

    What is the primary function of Entacapone in Parkinson's disease therapy?

    <p>Inhibit enzymes that degrade Levodopa in the brain</p> Signup and view all the answers

    How do Tolcapone and entacapone affect dopamine levels in the brain?

    <p>Prolong dopamine activity by blocking its reuptake</p> Signup and view all the answers

    What role does Amantadine play in Parkinson's disease treatment?

    <p>Promote dopamine release from storage sites</p> Signup and view all the answers

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