Podcast
Questions and Answers
Which drug class directly provides the substrate for dopamine synthesis?
Which drug class directly provides the substrate for dopamine synthesis?
- COMT inhibitors
- Dopamine precursor (correct)
- MAO-B inhibitors
- Dopamine facilitator
Entacapone and tolcapone increase dopamine levels, working by which mechanism?
Entacapone and tolcapone increase dopamine levels, working by which mechanism?
- Inhibiting COMT (correct)
- Inhibiting dopamine reuptake
- Stimulating dopamine release
- Inhibiting MAO-B
Why are carbidopa and benserazide typically administered alongside levodopa?
Why are carbidopa and benserazide typically administered alongside levodopa?
- To inhibit peripheral decarboxylase (correct)
- To reduce central nervous system side effects
- To enhance dopamine receptor sensitivity
- To directly stimulate dopamine release
Selegiline and rasagiline exert their effects on dopamine levels through which mechanism?
Selegiline and rasagiline exert their effects on dopamine levels through which mechanism?
Which of the following drugs acts as a dopamine agonist?
Which of the following drugs acts as a dopamine agonist?
Which of the following medications used to influence brain dopaminergic systems is classified as a dopamine facilitator?
Which of the following medications used to influence brain dopaminergic systems is classified as a dopamine facilitator?
A patient is prescribed benztropine for Parkinson's disease. How does this medication alleviate symptoms?
A patient is prescribed benztropine for Parkinson's disease. How does this medication alleviate symptoms?
Which drug, primarily used as an antihistamine, can also influence the brain's cholinergic system?
Which drug, primarily used as an antihistamine, can also influence the brain's cholinergic system?
A patient taking levodopa begins experiencing motor fluctuations. What adjunctive therapy aims to stabilize dopamine levels by preventing its breakdown?
A patient taking levodopa begins experiencing motor fluctuations. What adjunctive therapy aims to stabilize dopamine levels by preventing its breakdown?
A patient with drug-induced parkinsonism might be prescribed which of the following to reduce symptoms?
A patient with drug-induced parkinsonism might be prescribed which of the following to reduce symptoms?
Flashcards
Levodopa
Levodopa
A dopamine precursor drug used to increase dopamine levels in the brain.
Dopamine agonists
Dopamine agonists
Drugs that directly stimulate dopamine receptors in the brain.
Dopamine facilitator
Dopamine facilitator
A drug that enhances the effects of dopamine.
Peripheral decarboxylase inhibitors
Peripheral decarboxylase inhibitors
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MAO-B inhibitors
MAO-B inhibitors
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COMT inhibitors
COMT inhibitors
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Central anticholinergics
Central anticholinergics
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Antihistaminic (H1-blocker)
Antihistaminic (H1-blocker)
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Inhibition of Dopamine Metabolism
Inhibition of Dopamine Metabolism
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Dopamine receptor agonist
Dopamine receptor agonist
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Study Notes
- Pharmacology classification of drugs
Drugs Influencing Brain Dopaminergic System
- Dopamine Precursor: Levodopa
- Dopamine Agonists: Bromocriptine, Pergolide, Ropinirole, Pramipexole
- Dopamine Facilitator: Amantadine
- Peripheral Decarboxylase Inhibitors: Carbidopa, Benserazide
- MAO-B Inhibitors: Selegiline, Rasagiline
- COMT Inhibitors: Entacapone, Tolcapone
Drugs Affecting Brain Cholinergic System
- Central Anticholinergics: Benztropine, Benzhexol, Procyclidine, Biperiden, Trihexyphenidyl, Procyclidine
- Antihistaminic (H1-blocker): Orphenadrine, Promethazine
Drugs Increasing Brain Dopaminergic Activity
- Precursor of Dopamine
- Inhibition of Dopamine Metabolism
- Dopamine Receptor Agonist
- Drugs Increasing Presynaptic Release of Dopamine
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