Parkinson's Disease Dopaminergics

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What is the maximum daily dose of tolcapone (Tasmar) recommended for adults?

600 mg/d (correct)
800 mg/d
100 mg tid
200 mg tid

Which of the following is NOT a recommended first-line therapy for patients with mild to moderate parkinsonism symptoms?

Carbidopa-levodopa (correct)
Bromocriptine
Pramipexole
Pergolide

What is the recommended dosage range for rasagiline (Azilect) in the treatment of idiopathic Parkinson's disease in adults?

1.0-2.0 mg/d
0.5-1.0 mg/d (correct)
2.0-3.0 mg/d
0.25-0.75 mg/d

Which of the following Stalevo formulations contains the highest amount of levodopa?

Stalevo 200 (B) Signup and view all the answers

What is the recommended dosage of tolcapone (Tasmar) for adults with idiopathic Parkinson's disease?

100 mg tid (D) Signup and view all the answers

Which of the following Parkinson's disease medications has been used in the treatment of resistant depression?

Pramipexole (C) Signup and view all the answers

What is the possible effect of taking dopaminergics with antihypertensives?

Increased antihypertensive effect (D) Signup and view all the answers

How does taking carbidopa-levodopa with food affect its absorption?

Increases the plasma level of carbidopa-levodopa with the sustained-release form (C) Signup and view all the answers

What is the potential interaction between rasagiline and dextromethorphan?

Psychosis and bizarre behavior (D) Signup and view all the answers

What is the recommended dosage range for bromocriptine mesylate in the treatment of Parkinson's disease?

5 mg to 40 mg per day (A) Signup and view all the answers

What is the recommended initial dosage of pramipexole for the treatment of Parkinson's disease?

0.125 mg three times daily (A) Signup and view all the answers

What is the potential interaction between tolcapone and drugs metabolized by COMT?

Increased effect of the COMT-metabolized drugs (D) Signup and view all the answers

What is the potential interaction between rasagiline and meperidine?

Serious, sometimes fatal reactions (C) Signup and view all the answers

How does taking pramipexole with levodopa affect the dosage of levodopa?

Decreases the required dosage of levodopa (D) Signup and view all the answers

What is the maximum recommended daily dosage of amantadine for the treatment of Parkinson's disease?

400 mg per day (A) Signup and view all the answers

What is the recommended initial dosage of carbidopa-levodopa for the treatment of Parkinson's disease?

1 tablet (25 mg carbidopa/100 mg levodopa) three times daily (A) Signup and view all the answers

Which neurotransmitters are primarily responsible for balance and coordinated musculoskeletal functioning?

Dopamine and acetylcholine (A) Signup and view all the answers

What pharmacological treatment is considered the first choice for Parkinson's disease?

Amantadine (B) Signup and view all the answers

What is the role of amantadine in treating parkinsonism-like extrapyramidal symptoms (EPS) from antipsychotic drugs?

It enhances dopamine release (D) Signup and view all the answers

What symptoms are thought to be produced by excessive amounts of dopamine?

Hallucinations and delusions (B) Signup and view all the answers

Which of the following agents is NOT a dopaminergic used in the treatment of Parkinson's disease?

Fluoxetine (D) Signup and view all the answers

How does amantadine differ from levodopa in treating Parkinson's disease?

Amantadine increases dopamine release, while levodopa enhances dopamine reuptake. (D) Signup and view all the answers

What is the primary mechanism of action for entacapone when given with levodopa and carbidopa?

It enhances the pharmacokinetics of levodopa (C) Signup and view all the answers

Which of the following statements about bromocriptine and pergolide is true?

They act as dopamine agonists at postsynaptic receptor sites (C) Signup and view all the answers

How do selegiline and rasagiline increase the availability of dopamine in the central nervous system (CNS)?

They inactivate monoamine oxidase (MAO) (A) Signup and view all the answers

Which of the following statements about pramipexole and ropinirole is correct?

They stimulate dopamine receptors in the brain (C) Signup and view all the answers

Which of the following statements about the absorption and distribution of dopaminergics is correct?

They are administered orally and are relatively rapidly and completely absorbed (B) Signup and view all the answers

Which of the following drugs is metabolized in the liver?

All of the above (D) Signup and view all the answers

Which of the following statements about selegiline is correct?

It is contraindicated with concurrent administration of meperidine (A) Signup and view all the answers

Which of the following adverse effects is associated with the use of dopaminergics?

Sleep attacks (D) Signup and view all the answers

Which of the following drugs is contraindicated in patients with liver disease?

Tolcapone (A) Signup and view all the answers

Which of the following statements about drug interactions with dopaminergics is correct?

Concurrent use with antihypertensives may increase hypertension (D) Signup and view all the answers