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Questions and Answers
Which inhibitory neurotransmitter is involved in Parkinson's disease?
Which inhibitory neurotransmitter is involved in Parkinson's disease?
- Acetylcholine
- Oxytocin
- Dopamine (correct)
- Adrenaline
The healthcare provider orders entacapone 400 mg PO every 6 hours. The total dose given in a 24-hour period would be what amount?
The healthcare provider orders entacapone 400 mg PO every 6 hours. The total dose given in a 24-hour period would be what amount?
- 3200 mg
- 1400 mg
- 1600 mg (correct)
- 800 mg
Which adverse effect did the nurse find in the patient prescribed amantadine [Symadine]?
Which adverse effect did the nurse find in the patient prescribed amantadine [Symadine]?
- Dizziness (correct)
- Ataxia
- Difficulty breathing
- Dyskinesia
The healthcare provider orders amantadine 100 mg PO daily. Amantadine 10 mg/mL syrup is available. How many milliliters will the nurse administer?
The healthcare provider orders amantadine 100 mg PO daily. Amantadine 10 mg/mL syrup is available. How many milliliters will the nurse administer?
A patient with Parkinson's disease who has been positively responding to drug treatment with levodopa/carbidopa [Sinemet] suddenly develops a recurrence of symptoms. Which explanation by the nurse is appropriate?
A patient with Parkinson's disease who has been positively responding to drug treatment with levodopa/carbidopa [Sinemet] suddenly develops a recurrence of symptoms. Which explanation by the nurse is appropriate?
What should the nurse anticipate as the reason for suggesting combination therapy with a monoamine oxidase inhibitor (MAOI) alongside carbidopa-levodopa [Sinemet]?
What should the nurse anticipate as the reason for suggesting combination therapy with a monoamine oxidase inhibitor (MAOI) alongside carbidopa-levodopa [Sinemet]?
What is the correct order for selegiline [Eldepryl] in a patient with Parkinson's disease?
What is the correct order for selegiline [Eldepryl] in a patient with Parkinson's disease?
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Study Notes
Parkinson's Disease and Neurotransmitters
- Dopamine is the key inhibitory neurotransmitter involved in Parkinson's disease, linked to its low concentrations in affected individuals.
- Acetylcholine serves as an excitatory neurotransmitter that counters dopamine.
Medication Dosage Calculation
- Entacapone dosage of 400 mg every 6 hours equals a total of 1600 mg in a 24-hour period (400 mg x 4 doses).
Adverse Effects of Amantadine
- Dizziness is a common adverse effect associated with amantadine, necessitating caution when changing positions to prevent sudden blood pressure drops.
Amantadine Syrup Administration
- For an ordered dose of 100 mg of amantadine and a concentration of 10 mg/mL, the nurse administers 10 mL of syrup (100 mg / 10 mg/mL).
"On-off" Phenomenon in Levodopa/Carbidopa Treatment
- Recurrence of symptoms in patients on levodopa/carbidopa indicates the 'on-off' phenomenon, where adjustments to the medication regimen may lessen these episodes.
MAOIs and Carbidopa-Levodopa Synonymy
- Monoamine oxidase inhibitors (MAOIs) are prescribed alongside carbidopa-levodopa to enhance efficacy, particularly when patients become insensitive to treatment over time.
Selegiline Administration Protocol
- The correct administration order for selegiline [Eldepryl] involves a dosage of 5 mg twice daily, which is appropriate for treating depression in Parkinson's disease patients.
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