Questions and Answers
Which inhibitory neurotransmitter is involved in Parkinson's disease?
The healthcare provider orders entacapone 400 mg PO every 6 hours. The total dose given in a 24-hour period would be what amount?
Which adverse effect did the nurse find in the patient prescribed amantadine [Symadine]?
The healthcare provider orders amantadine 100 mg PO daily. Amantadine 10 mg/mL syrup is available. How many milliliters will the nurse administer?
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A patient with Parkinson's disease who has been positively responding to drug treatment with levodopa/carbidopa [Sinemet] suddenly develops a recurrence of symptoms. Which explanation by the nurse is appropriate?
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What should the nurse anticipate as the reason for suggesting combination therapy with a monoamine oxidase inhibitor (MAOI) alongside carbidopa-levodopa [Sinemet]?
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What is the correct order for selegiline [Eldepryl] in a patient with Parkinson's disease?
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Study Notes
Parkinson's Disease and Neurotransmitters
- Dopamine is the key inhibitory neurotransmitter involved in Parkinson's disease, linked to its low concentrations in affected individuals.
- Acetylcholine serves as an excitatory neurotransmitter that counters dopamine.
Medication Dosage Calculation
- Entacapone dosage of 400 mg every 6 hours equals a total of 1600 mg in a 24-hour period (400 mg x 4 doses).
Adverse Effects of Amantadine
- Dizziness is a common adverse effect associated with amantadine, necessitating caution when changing positions to prevent sudden blood pressure drops.
Amantadine Syrup Administration
- For an ordered dose of 100 mg of amantadine and a concentration of 10 mg/mL, the nurse administers 10 mL of syrup (100 mg / 10 mg/mL).
"On-off" Phenomenon in Levodopa/Carbidopa Treatment
- Recurrence of symptoms in patients on levodopa/carbidopa indicates the 'on-off' phenomenon, where adjustments to the medication regimen may lessen these episodes.
MAOIs and Carbidopa-Levodopa Synonymy
- Monoamine oxidase inhibitors (MAOIs) are prescribed alongside carbidopa-levodopa to enhance efficacy, particularly when patients become insensitive to treatment over time.
Selegiline Administration Protocol
- The correct administration order for selegiline [Eldepryl] involves a dosage of 5 mg twice daily, which is appropriate for treating depression in Parkinson's disease patients.
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Description
This quiz covers key aspects of Parkinson's disease, focusing on the role of neurotransmitters like dopamine and acetylcholine. It also addresses medication dosage calculations, adverse effects of amantadine, and the 'on-off' phenomenon associated with levodopa/carbidopa treatment. Test your knowledge on these important topics in Parkinson's care.
