15 Questions
Which type of receptor is responsible for the slowing of heart rate?
Muscarinic M2 receptor
What is the effect of activating the metabotropic M3 receptor?
Contraction of smooth muscle
Which receptor subtype is involved in the release of adrenaline and noradrenaline from the adrenal medulla?
Nicotinic receptor
What is the function of the nicotinic receptor at the neuromuscular junction?
ALL
Which G-protein coupled receptor (GPCR) subtype is involved in promoting the influx of calcium to increase heart rate?
Alpha adrenoreceptor
In which location are muscarinic receptors found?
All organs innervated by parasympathetic postganglionic nerve fibers
What is the role of the alpha q type G-protein coupled receptor (GPCR) when activated?
Promotes contraction of smooth muscle
What is the general composition of all nicotinic receptors?
5 subunits and ligand-gated ion channels
Which of the following is a subtype of muscarinic receptor responsible for salivary and gastric acid secretion?
M1
What is the effect of activating the metabotropic M2 receptor?
Decreases cyclic AMP and lowers heart rate
What is the role of the alpha q type G-protein coupled receptor (GPCR) when activated?
Binds an extra phosphate to have GTP, interacts with enzyme phospholipase C to make IP3 and DAG -opens calcium channel and out-flux of calcium promoting contraction
Which G-protein coupled receptor (GPCR) subtype is involved in promoting the influx of calcium to increase heart rate?
Alpha s
What is the general composition of all nicotinic receptors?
Composed of 5 subunits and are all ligand-gated ion channels
Which subtype of muscarinic receptor is responsible for smooth muscle contraction in the gastrointestinal and respiratory tract?
M3
What is the effect of activating the metabotropic M3 receptor?
Smooth muscle contraction
Study Notes
Receptors and Their Functions
- Muscarinic receptors are responsible for slowing down heart rate.
- Activating the metabotropic M3 receptor increases smooth muscle contraction, particularly in the gastrointestinal and respiratory tract.
- The M1 receptor subtype is involved in the release of adrenaline and noradrenaline from the adrenal medulla.
- The nicotinic receptor at the neuromuscular junction is responsible for muscle contraction.
- The alpha 1 receptor subtype, a G-protein coupled receptor (GPCR), promotes the influx of calcium to increase heart rate.
- Muscarinic receptors are found in the brain, autonomic ganglia, and peripheral tissues.
- Activating the alpha q type G-protein coupled receptor (GPCR) increases phospholipase C activity.
- All nicotinic receptors are composed of five subunits.
- The M1 subtype of muscarinic receptor is responsible for salivary and gastric acid secretion.
- Activating the metabotropic M2 receptor slows down heart rate.
- The M3 subtype of muscarinic receptor is responsible for smooth muscle contraction in the gastrointestinal and respiratory tract.
- Activating the metabotropic M3 receptor increases smooth muscle contraction, particularly in the gastrointestinal and respiratory tract.
Test your knowledge of acetylcholine receptors with this quiz. Explore the roles of nicotinic receptors in the parasympathetic and sympathetic ganglia, adrenal medulla, skeletal muscle, neuromuscular junction, and central nervous system. Dive into the actions of nicotinic receptors, including their involvement in ganglia transmission, skeletal muscle contraction, and the release of adrenaline and noradrenaline.
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