22 Questions
What type of iron therapy is reserved for patients who are unable to absorb oral iron and for patients with extensive chronic anemia who cannot be maintained with oral iron alone?
Parenteral
Which of the following is the first human hematopoietic growth factor to be isolated?
Thrombopoietin
Which medication dramatically accelerates the rate of neutrophil recovery after dose-intensive myelosuppressive chemotherapy?
Romiplostim
Which medication is approved for the therapy of patients with chronic immune thrombocytopenia who have had an inadequate response to other therapies?
Eleltrombopag
Which medication is approved for the secondary prevention of thrombocytopenia in patients receiving cytotoxic chemotherapy for the treatment of non-myeloid cancers?
Oprelvekin
True or False: Folate deficiency results in a megaloblastic anemia that is microscopically indistinguishable from the anemia caused by vitamin B12 deficiency.
True
What causes anemia that is microscopically indistinguishable from the anemia caused by vitamin B12 deficiency?
Iron deficiency
What is the role of GM-CSF in reducing neutropenia?
Decreasing the frequency of infections
In addition to cytotoxic chemotherapy, where else have G-CSF and GM-CSF been effective?
Treating neutropenia associated with certain disorders
What is the purpose of combining G-CSF or GM-CSF with other growth factors?
Treating pancytopenia
What is the role of myeloid growth factors in autologous stem cell transplantation?
Reducing the time to engraftment and recovery from neutropenia
What is the primary purpose of high-dose chemotherapy with autologous stem cell support?
Treating tumors resistant to standard doses of chemotherapeutic drugs
How do G-CSF and GM-CSF help in autologous stem cell transplantation?
By increasing the time to engraftment and recovery from neutropenia
'Pancytopenia' refers to a condition characterized by a reduction in the number of:
All types of blood cells
'Myelosuppression' resulting from high-dose chemotherapy can be counteracted by:
Reinfusion of the patient’s own hematopoietic stem cells
What is the primary indication for parenteral iron therapy?
Documented iron deficiency in patients who can tolerate and absorb oral iron
Which condition is NOT a potential indication for parenteral iron therapy?
Proximal bowel involvement in inflammatory bowel disease
What are the three traditional forms of parenteral iron mentioned in the text?
Iron dextran, Sodium ferric gluconate complex, Iron sucrose
In which patient population is acute iron toxicity seen almost exclusively?
Young children
How many tablets of commonly available oral iron preparations can be lethal in young children?
As few as 10 tablets
What clinical manifestations are experienced by young children poisoned with oral iron?
Necrotizing gastroenteritis and vomiting
What serious condition may follow improvements in children poisoned with oral iron?
Severe metabolic acidosis
This quiz covers the indications for parenteral iron therapy, including conditions where patients are unable to tolerate or absorb oral iron and those with extensive chronic anemia. It also includes situations such as advanced chronic renal disease, post gastrectomy conditions, small bowel resection, inflammatory bowel disease, and malabsorption syndromes.
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