Parasitology & Mycology 2024/2025 - Mycology

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Questions and Answers

Which of the following fungi is specifically known for causing superficial mycoses including dermatomycoses?

  • Mucor racemosus
  • Blastomyces dermatidis
  • Aspergillus fumigatus
  • Trichophyton rubrum (correct)

What characteristic enables potentially pathogenic fungi to survive in injured and diseased tissues?

  • Resistance to antibiotics
  • Increased size of spores
  • Ability to reproduce rapidly
  • Ability to grow at human body temperature (correct)

In immunocompetent persons, the prevalence of fungi in the oral cavity can reach up to what percentage?

  • 50% (correct)
  • 25%
  • 75%
  • 5%

Which of the following is NOT a group of fungi characterized by an aerial mycelium?

<p>Dermatophytes (C)</p> Signup and view all the answers

What percentage of patients in risk groups is likely to have fungal colonization in the esophagus and stomach?

<p>43-60% (C)</p> Signup and view all the answers

What is a primary component of the cell wall in fungi?

<p>Chitin (B)</p> Signup and view all the answers

Which of the following is NOT a type of asexual spore in fungi?

<p>Zygospore (D)</p> Signup and view all the answers

What term describes the complete life cycle of a fungus that produces both sexual and asexual spores?

<p>Holomorphy (D)</p> Signup and view all the answers

Which fungal reproductive structure is typically associated with the phylum Ascomycota?

<p>Ascospore (B)</p> Signup and view all the answers

Which characteristic of fungi is associated with their saprotrophic nature?

<p>Decomposition of organic matter (D)</p> Signup and view all the answers

Which form of fungus produces asexual spores during its life cycle?

<p>Anamorph (D)</p> Signup and view all the answers

What is the typical resting spore formed in the phylum Zygomycota?

<p>Zygospore (D)</p> Signup and view all the answers

What is one major trend observed in the reproductive strategies of some fungi?

<p>Loss of sexual stages (D)</p> Signup and view all the answers

What type of spore is formed as an endospore in a sporangium?

<p>Sporangiospore (C)</p> Signup and view all the answers

Which type of spore is produced by the disintegration of hyphae?

<p>Arthroconidium (D)</p> Signup and view all the answers

Mycotoxicoses refer to diseases resulting from?

<p>Ingestion of fungal toxins (B)</p> Signup and view all the answers

What structure do phialoconidia form on?

<p>Conidiophore (A)</p> Signup and view all the answers

Which of the following types of fungi is known for forming spores by budding?

<p>Blastoconidium (B)</p> Signup and view all the answers

What is a feature of dimorphic fungi?

<p>They can switch anatomical forms based on temperature. (A)</p> Signup and view all the answers

What condition increases the risk of fungal diseases significantly?

<p>Immunocompromised persons (A)</p> Signup and view all the answers

Which of the following best describes mycoallergies?

<p>Caused by hypersensitivity to fungal antigens (C)</p> Signup and view all the answers

Which factor is NOT associated with the development of asymptomatic infection in symptomatic mycosis?

<p>Proliferation of fungi (B)</p> Signup and view all the answers

Which of the following characteristics makes the hyphal form of Candida spp. more pathogenic than the yeast form?

<p>Dimorphism / phenotypic variability (A)</p> Signup and view all the answers

What is the average detection rate of fungi in the oral cavity based on the provided data?

<p>83.4% (D)</p> Signup and view all the answers

Which of the following is NOT an etiological factor for oral candidiasis?

<p>Aspergillus niger (D)</p> Signup and view all the answers

What role does adherence play in the pathogenicity of Candida spp.?

<p>Allows binding to host cells (D)</p> Signup and view all the answers

Which forms of mucormycosis are associated with the gastrointestinal tract?

<p>gastrointestinal mucormycosis (A)</p> Signup and view all the answers

What is the mortality rate for patients with mucormycosis?

<p>30-97% (D)</p> Signup and view all the answers

Which of the following patient groups is at the highest risk for rhino-orbito-cerebral mucormycosis?

<p>Patients with diabetes experiencing ketoacidosis (B)</p> Signup and view all the answers

Which symptom is associated with rhino-orbital-cerebral mucormycosis?

<p>periorbital swelling with loss of vision (A)</p> Signup and view all the answers

What is the primary cause of aspergillosis?

<p>Inhalation of conidia from the air (B)</p> Signup and view all the answers

Which condition is associated with cerebral aspergillosis?

<p>Meningitis (A)</p> Signup and view all the answers

What is not a clinical form of oral candidiasis?

<p>Urticaria (B)</p> Signup and view all the answers

Which of these fungi is not part of the genus Candida?

<p>Cryptococcus neoformans (A)</p> Signup and view all the answers

Which symptom is commonly associated with vaginal candidiasis?

<p>Abundant, thick, whitish discharge (C)</p> Signup and view all the answers

What potential complication can arise from disseminated candidiasis?

<p>Encephalitis (B)</p> Signup and view all the answers

Which infection is characterized by granulomatous tumors in the brain due to fungal pathogens?

<p>Aspergillosis (D)</p> Signup and view all the answers

What is a common mode of infection for Candida spp. in the body?

<p>Through the bloodstream (B)</p> Signup and view all the answers

Which of the following is not a form of candidiasis?

<p>Pneumocystis pneumonia (C)</p> Signup and view all the answers

Which type of aspergillosis is associated with pre-existing cavities in the lungs?

<p>Aspergilloma (D)</p> Signup and view all the answers

What percentage of women potentially experience recurrent vaginal candidiasis?

<p>40-50% (B)</p> Signup and view all the answers

Flashcards

Fungal Cell Wall

Composed of chitin and chitosan.

Fungal Reserve Material

Glycogen.

Fungal Nutrition

Heterotrophic, primarily osmotrophic.

Fungal Body Structure

Mycelium, budding cells, or slime.

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Fungal Reproduction

Produces spores, both sexual and asexual.

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Fungal Spores (Sexual)

Zygospores, ascospores, basidiospores.

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Fungal Spores (Asexual)

Conidia, sporangiospores, chlamydospores.

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Holomorphy

Full life cycle of a fungus, including both sexual and asexual stages.

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Basidiospore

A spore of fungi in the Basidiomycota phylum, formed on a basidium.

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Teleomorph

The sexual stage of a fungus, producing sexual spores.

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Sporangiospore

A spore of fungi in the Zygomycota phylum, formed inside a sporangium.

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Anamorph

The asexual stage of a fungus, producing asexual spores.

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Blastoconidium

A spore formed by budding in fungi

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Fungal Plasticity

Adaptability and enzymatic activity allowing fungi to grow in various environments

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Aleuroconidium

A spore formed directly on a hypha (fungal filament).

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Fungal Saprotrophy

Obtain energy by decomposing dead organisms and organic matter.

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Macroconidia

Larger, multicelled spores.

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Microconidia

Smaller, unicelled spores.

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Phialoconidium

A spore formed on a specialized structure (conidiophore).

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Arthroconidium

Spore formed by the fragmentation (breaking) of a hypha.

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Chlamydospore

A thick-walled resting spore of various fungi found in Zygomycota, Ascomycota, Basidiomycota.

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Yeast

A fungus whose main method of reproduction is budding.

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Dimorphic Fungi

Fungi that have different forms depending on temperature.

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Potentially pathogenic fungi

Fungi that can grow and survive at human body temperature in injured or diseased tissues.

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Fungal colonization

Fungi growing in the body, sometimes causing no symptoms.

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Immunocompetent hosts

People with a healthy immune system.

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Dermatophytes

Fungi causing skin and nail infections.

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Molds

Filamentous fungi with a well-formed mycelium, found in various environments.

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Aspergillus fumigatus

A type of mold; a common airborne fungus.

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Mucor racemosus

Another mold type, from a specific group .

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Trichophyton rubrum & Microsporum gypseum

Specific types of dermatophytes causing skin and nail infections.

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Global Fungal Infections

Over 300 million people are affected and 25 million are at high risk of serious outcomes.

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Urbanization

The increasing concentration of human populations in urban areas.

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Industrialization

The process of developing industries in a society.

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Anthropopression

Environmental pressure resulting from human activities.

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Diet

The types and amounts of food a person consumes.

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Lifestyle

A way of life, encompassing habits, routines, and choices.

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Asymptomatic Infection

Infection without noticeable symptoms.

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Mycosis

Fungal infection.

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Candida spp.

Species of a genus of fungi that cause infections.

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Features of pathogenicity

Characteristics that make a fungus harmful to a host.

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Risk factors for candidiasis

Conditions increasing the chance of fungal infection.

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Host immune system

The body's defense mechanism against pathogens.

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Proliferation

Rapid increase in cell number (fungi or otherwise).

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Oral cavity candidiasis

Fungal infection of the mouth.

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Oral Cavity

The mouth, pharynx, and other areas in the head that form the initial area of food digestion

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Mucormycosis

A fungal infection caused by fungi like Absidia, Mucor, Rhizomucor, and Cunninhamella.

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Rhinocerebral mucormycosis

Mucormycosis affecting the upper respiratory tract and brain.

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Increased Mucormycosis Risk

Individuals with diabetes (especially ketoacidosis), hematological diseases, transplants, and some gastrointestinal/kidney diseases are at higher risk.

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Aspergillosis

A fungal infection caused by Aspergillus fungi.

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Aspergillus fumigatus

A specific type of Aspergillus fungus, a common cause of aspergillosis.

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Mucormycosis Symptoms (rhino-orbital-cerebral)

Headaches (around the face), periorbital swelling/vision loss, fever, double vision, black nasal discharge, ulcers/perforation of the palate, mental changes, and stroke.

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Aspergillosis Cause

Inhaling Aspergillus conidia from the air.

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Mucormycosis Mortality

Mucormycosis has a high mortality rate (30-97%).

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Immunocompromised patients

Individuals with weakened immune systems are more vulnerable to fungal infections like aspergillosis and mucormycosis.

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Aspergillosis

A fungal infection caused by Aspergillus, affecting various body parts, including the lungs, brain, skin, and more.Can take different forms, including pneumonia, aspergilloma(colonization in pre-existing holes), mould-asthma

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Cerebral aspergillosis

Aspergillosis affecting the brain, leading to potentially serious issues like intracranial pressure.

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Candida spp.

Opportunistic fungal pathogens frequently colonizing the gastrointestinal tract, able to invade deeper tissues of many organs.

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Candida albicans

A type of Candida fungus, often involved in common infections.

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Disseminated candidiasis

A severe form of candidiasis where the infection spreads throughout the body.

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Oral thrush

A type of oral candidiasis, characterized by white patches in the mouth, that can be acute.

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Vaginal candidiasis

A common yeast infection affecting the vagina and vulva, and is common in females.

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Cryptococcosis

Fungal infection caused by Cryptococcus, mainly affecting the brain and lungs.

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Cryptococcus neoformans

A specific fungus causing cryptococcosis.

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Study Notes

Parasitology & Mycology 2024/2025 - Mycology

  • Fungi have chitin and chitosan in their cell walls, and use glycogen as a reserve material.
  • Fungi are heterotrophic, meaning they obtain nutrients from other sources.
  • Fungi reproduce sexually or asexually, forming spores.
  • Forms of sexual spores include zygospores, ascospores, and basidiospores.
  • Forms of asexual spores include sporangiospores, conidia, and chlamydospores.
  • Fungi have two forms: teleomorph (sexual) and anamorph (asexual).
  • Fungi reproduce by the formation of spores that may be either sexual or asexual.
  • Fungi can be pathogenic, causing various infections in humans.
  • Fungi cause many types of human diseases including mycoallergies, mycotoxicoses, and mycoses.
  • Medical mycology groups fungi into yeasts, molds, and dimorphic fungi.
  • Yeasts reproduce by budding.
  • Molds have a well-developed aerial mycelium.
  • Dimorphic fungi can change their form depending on environmental conditions.
  • Different types of fungi cause various diseases depending on severity, localized or spread.
  • Fungal infections can occur in many parts of the body: skin, oral cavity, vagina, lungs, and more.
  • Risk factors for fungal infections include immune deficiency, diabetes, certain surgeries, and some medications.

Classification of mycoses

  • Mycoses are classified by acquisition route (exogenous or endogenous) and site of infection (superficial, cutaneous, subcutaneous or systemic).
  • Superficial mycoses affect the outermost layers of the skin.
  • Cutaneous mycoses involve keratinized tissues (skin, hair, nails).
  • Subcutaneous mycoses affect deeper layers of the skin.
  • Systemic mycoses affect multiple organs.

WHO Fungal Priority Pathogen List

  • Includes critical, high, and medium-risk groups of fungi.
  • Classifies fungi based on different safety precautions.

Fungal Pathogenesis

  • Factors affecting fungal infection development can include host's immune system, pathogenicity of fungal strains, and host organism's condition.
  • Fungi invade through various mechanisms, including adherence, enzymatic activity, and mimicking host molecules.
  • Virulence factors of Candida albicans include adhesins and hydrolytic enzymes.
  • Oral candidosis can be categorized as pseudomembranous, erythematous, or hyperplastic forms.
  • There are multiple factors contributing to both localized and systemic infections.
  • Specific types of mycoses will have distinctive symptoms.

Antifungal Drugs

  • Different types of oral antifungal drugs are useful for different types of fungal infections.
  • Drug selection depends on the type and severity of infection.
  • Several guidelines and regimens exist for drug intervention based on the species of fungus.

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