Parasitology Lecture: Introduction
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Questions and Answers

What is a distinguishing feature of Entamoeba coli trophozoites?

  • They possess a large, irregular-shaped karyosome. (correct)
  • They are typically smaller than other amoebas.
  • They exhibit fast, directional movement.
  • They are commonly found in the bloodstream.
  • Which amoeba species has a characteristic 'basket nucleus' in its cyst stage?

  • _Iodamoeba bütschlii_ (correct)
  • _Endolimax nana_
  • _Entamoeba coli_
  • _Entamoeba gingivalis_
  • Which of the following amoeba species is commonly described as 'iodine-loving'?

  • _Endolimax nana_
  • _Iodamoeba bütschlii_ (correct)
  • _Entamoeba coli_
  • _Entamoeba gingivalis_
  • What is a distinguishing feature of Endolimax nana trophozoites?

    <p>They are typically much smaller than other amoebas. (B)</p> Signup and view all the answers

    Which amoeba species has a cyst stage that often contains splinter-shaped chromatoidals?

    <p><em>Entamoeba coli</em> (C)</p> Signup and view all the answers

    Which amoeba species is most closely related in morphology to Entamoeba gingivalis?

    <p><em>Entamoeba histolytica</em> (B)</p> Signup and view all the answers

    Which amoeba species typically possesses a large glycogen vacuole in its cyst stage?

    <p><em>Iodamoeba bütschlii</em> (A)</p> Signup and view all the answers

    Which amoeba species is the most common of the smaller intestinal amoebas?

    <p><em>Endolimax nana</em> (D)</p> Signup and view all the answers

    Which of the following species of Entamoeba is considered non-pathogenic and does not cause infections?

    <p>Entamoeba coli (A), Entamoeba hartmanni (D)</p> Signup and view all the answers

    Which species of Entamoeba is known to be nine times more prevalent than Entamoeba histolytica?

    <p>Entamoeba dispar (C)</p> Signup and view all the answers

    Which species of Entamoeba is commonly found in tropical regions with poor sanitation and can cause mild gastrointestinal symptoms or diarrhea?

    <p>Entamoeba moshkovskii (D)</p> Signup and view all the answers

    What is the main difference between Entamoeba histolytica, Entamoeba dispar, and Entamoeba hartmanni?

    <p>Their size (B)</p> Signup and view all the answers

    Which of the following factors contribute to the prevalence of E. histolytica infections?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following parasites can cause intestinal obstruction?

    <p>Fasciolopsis buski (C)</p> Signup and view all the answers

    What is the main effect of Necator americanus on its host?

    <p>Deprivation of iron by sucking blood (B)</p> Signup and view all the answers

    Which of the following parasites is characterized by having a pre-adaptive change that involves the development of suckers and hooks?

    <p>Hymenolepis nana (C)</p> Signup and view all the answers

    Which of the following factors can affect the severity of the effects a parasite has on its host?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary mechanism by which Plasmodium falciparum causes damage to its host?

    <p>Directly attacking and destroying red blood cells (C)</p> Signup and view all the answers

    Which of the following statements accurately describes the term "pre-adaptation" in the context of parasitism?

    <p>Features that already exist in a parasite that make it suitable for a parasitic lifestyle (B)</p> Signup and view all the answers

    How does Entamoeba histolytica penetrate the intestinal mucosa?

    <p>By secreting digestive enzymes that break down the tissue (C)</p> Signup and view all the answers

    Which of the following is an example of an ectoparasite?

    <p>Fleas (A)</p> Signup and view all the answers

    What is the significance of the "Duffy null phenotype" in relation to malaria?

    <p>It makes individuals resistant to infection by <em>Plasmodium falciparum</em> (D)</p> Signup and view all the answers

    What is the primary way that parasites evade the host's immune system?

    <p>Rapidly changing their surface antigens (B)</p> Signup and view all the answers

    How does Entamoeba histolytica spread to the liver?

    <p>Through the blood stream via the portal vein (C)</p> Signup and view all the answers

    What is the primary mechanism by which Entamoeba histolytica causes cell death?

    <p>Production of toxins (A)</p> Signup and view all the answers

    Which of the following parasites is a facultative parasite?

    <p>Balantidium coli (B)</p> Signup and view all the answers

    Which of the following is NOT a mechanism of Entamoeba histolytica's virulence?

    <p>Inhibition of DNA replication (D)</p> Signup and view all the answers

    What role does a paratenic host play in the parasite's life cycle?

    <p>Provides a temporary haven for the parasite, allowing it to survive but not develop further. (A)</p> Signup and view all the answers

    Which of the following is NOT a potential consequence of a ruptured liver abscess caused by Entamoeba histolytica?

    <p>Amoebic dysentery (A)</p> Signup and view all the answers

    Which drug works by interfering with the protein synthesis of Entamoeba histolytica by binding to the 30S ribosomal subunit?

    <p>Paramomycin (B)</p> Signup and view all the answers

    A parasite's ability to survive and reproduce relies on its ability to:

    <p>All of the above. (D)</p> Signup and view all the answers

    What is the difference between an intermediate host and a definitive host?

    <p>An intermediate host holds the infective stage while a definitive host allows sexual reproduction to occur. (D)</p> Signup and view all the answers

    What is the primary mechanism of action of Metronidazole in treating Entamoeba histolytica infections?

    <p>Disrupting DNA replication (B)</p> Signup and view all the answers

    Which of the following is a common preventive measure against Entamoeba histolytica infection?

    <p>Avoiding consumption of street foods (D)</p> Signup and view all the answers

    Which of the following is NOT a key characteristic of an obligate parasite?

    <p>Capable of free-living existence. (C)</p> Signup and view all the answers

    What is the role of the Gal/GalNac-binding lectin in the pathogenesis of Entamoeba histolytica?

    <p>Promoting the adhesion and contact-dependent toxicity of the parasite to host cells (C)</p> Signup and view all the answers

    Which class of arthropods is considered the most important?

    <p>Insecta (B)</p> Signup and view all the answers

    What is the characteristic feature of centipedes?

    <p>Their first pair of appendages are poison claws. (D)</p> Signup and view all the answers

    Which insect acts as a vector for Trypanosoma cruzi?

    <p>Cone-nose bugs (B)</p> Signup and view all the answers

    What is the feeding stage of Amoeba called?

    <p>Trophozoite (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the cyst stage of Amoeba?

    <p>Found in liquid stools (A)</p> Signup and view all the answers

    Which of the following is NOT a class within the sub-phylum Sarcodina?

    <p>Kinetofragminophorea (C)</p> Signup and view all the answers

    What does the term 'endemic' mean in terms of disease distribution?

    <p>A disease that is present in a population at a steady rate. (A)</p> Signup and view all the answers

    Which of the following terms refers to the number of new cases of a disease in a given period?

    <p>Incidence (C)</p> Signup and view all the answers

    What is a pandemic?

    <p>A disease that spreads over a wide geographical area, potentially affecting a large portion of the globe. (A)</p> Signup and view all the answers

    Which insect is known to be an intermediate host (IH) for Hymenolepsis nana?

    <p>Grain beetle (D)</p> Signup and view all the answers

    What is the intermediate host (IH) for Dipylidium caninum?

    <p>Fleas (D)</p> Signup and view all the answers

    Which arthropods are known to be vectors for diseases?

    <p>Only insects (B)</p> Signup and view all the answers

    Which of the following statements is TRUE about Amoeba?

    <p>Amoeba are unicellular organisms. (C)</p> Signup and view all the answers

    What is the diagnostic stage of Amoeba?

    <p>Trophozoite (B)</p> Signup and view all the answers

    Which of these is NOT a characteristic of the trophozoite stage of Amoeba?

    <p>Non-motile (C)</p> Signup and view all the answers

    What is the difference between incidence and prevalence?

    <p>Prevalence refers to all cases at a specific time while incidence refers to new cases in a defined period. (D)</p> Signup and view all the answers

    Signup and view all the answers

    Flashcards

    Endoparasite

    A parasite that lives inside the host, causing infection.

    Ectoparasite

    A parasite that lives on the outside of the host, causing infestation.

    Pre-adaptation

    Changes that enable survival in unfavorable environments under parasitic conditions.

    Suckers and hooks

    Specialized attachment organs developed by parasitic flatworms.

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    Immune evasion

    Parasites alter their surface to avoid detection by the host's immune system.

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    Fasciolopsis buski

    A parasite that causes local damage to the intestinal wall using suckers.

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    Entamoeba histolytica

    An intestinal amoeba that erodes the intestinal wall with proteolytic enzymes.

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    Plasmodium falciparum

    Parasite that invades and multiplies in red blood cells, causing severe issues.

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    Necator americanus

    A hookworm that deprives the host of iron by sucking blood, leading to anemia.

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    Duffy null phenotype

    A genetic characteristic providing resistance to Plasmodium falciparum infection.

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    Definitive Host

    The host where a parasite reaches maturity and reproduces.

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    Intermediate Host

    A host where the parasite develops but does not reach maturity.

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    Paratenic Host

    A host that allows the parasite to survive in an arrested state without further development.

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    Reservoir Host

    A host that harbors a parasite and can transmit it to others.

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    Obligate Parasite

    A parasite that cannot survive without a host.

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    E. histolytica liver infection

    E. histolytica can spread via the portal vein and infect the liver.

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    Cysteine proteinase

    An enzyme that degrades host proteins, helping E. histolytica attach to the gut.

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    Gal/GalNAc-binding lectin

    A lectin that binds to galactose and N-acetylgalactosamine for cell adherence.

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    Amebapore

    Protein that forms ion channels in phagocytized eukaryotic cells.

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    Diloxanide furoate

    A treatment that prevents protein synthesis in the protozoa.

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    Paramomycin

    Antibiotic that binds to the 30S ribosomal subunit, interfering with protein synthesis.

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    Metronidazole

    A drug that damages DNA leading to cell death in amoebic infections.

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    Prevention methods for E. histolytica

    Boil water, avoid human feces fertilizers, and steer clear of street food.

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    E. histolytica

    An intestinal amoeba causing serious disease by invading the intestinal wall.

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    E. dispar

    A non-pathogenic amoeba, morphologically similar to E. histolytica, generally asymptomatic.

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    E. moshkovskii

    A non-pathogenic amoeba found in tropical areas; prevalence and disease role unclear.

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    E. coli (amoeba)

    A non-pathogenic amoeba resembling E. histolytica, does not cause infections.

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    Sanitation and amoebiasis

    Level of sanitation affects amoebiasis prevalence; higher in tropical regions.

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    Chilopoda

    Class of arthropods known as centipedes, characterized by one pair of poison claws.

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    Class Insecta

    Largest class of arthropods, with a body divided into head, thorax, and abdomen.

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    Anoplura

    Order that includes human lice, external parasites that feed on blood.

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    Hemiptera

    Order featuring cone-nose bugs, which can transmit Trypanosoma cruzi.

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    Incidence

    The number of new cases of a disease in a defined time period.

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    Prevalence

    The total number of existing cases of a disease in a population at a given time.

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    Endemic

    Disease that is consistently present in a specific population or region.

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    Epidemic

    A sudden increase in the incidence of a disease above what is normally expected.

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    Pandemic

    A disease that has spread across several countries or continents, affecting a large number of people.

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    Trophozoite

    The active, feeding stage of amoebae, characterized by motility.

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    Cyst

    The inactive, non-feeding stage of amoebae, formed in stool.

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    Morphologic Forms

    Different structural forms of amoeba, specifically the trophozoite and cyst stages.

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    Phylum Sarcomastigophora

    Phylum that includes subphyla Sarcodina (amoebae) and Mastigophora (flagellates).

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    Sub-phylum Sarcodina

    Sub-phylum of the phylum Sarcomastigophora, includes amoebae.

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    Endolimax nana

    The most common smaller intestinal amoeba, similar in size to E. hartmanni.

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    Entamoeba gingivalis

    The first parasitic amoeba described in humans, resembling E. histolytica.

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    Iodamoeba butschlii

    An amoeba known as 'iodine-loving,' with a distinct basket of nuclear granules.

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    Cytoplasmic inclusions

    Vacuoles within amoebas that can contain bacteria or other substances.

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    Karyosome

    The clustering of chromatin within the nucleus of an amoeba.

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    Shape of Endolimax cyst

    Spherical with a size range similar to E. hartmanni.

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    Study Notes

    Parasitology Lecture: Introduction

    • Host Types:

      • Definitive/Final Host: The host where the parasite reaches sexual maturity.
      • Intermediate Host: The host where the parasite develops into an infective stage.
      • Paratenic Host: An underdeveloped/arrested state of development, where the parasite may reside without undergoing further development.
      • Reservoir Host: A host that can harbor a parasite without showing symptoms, offering a potential source of infection.
    • Parasite Classification (based on relationship with host):

      • Obligate parasite: The parasite cannot live outside of a host.
      • Facultative parasite: Can live independently or as a parasite, depending on conditions.
      • Temporary parasite: Visits a host for feeding.
      • Intermittent parasite: Occurs periodically in or on the host.
      • Endoparasite: Lives inside the host.
      • Ectoparasite: Lives on the host's surface.
    • Parasite Classification (based on habitat):

      • Obligatory; Free-living: The parasite lives independently in the environment.
      • Obligatory; Parasitic: Lives exclusively as a parasite
      • Facultative; Commensal: The parasite benefits from the host but does not harm it.
      • Facultative; Parasitic: The parasite benefits by harming the host.
    • Parasite Adaptations:

      • Pre-adaptation: Adaptations that allow the parasite to exist in unfavorable environments.
      • Mechanisms to increase resistance to host defenses (e.g., suckers, hooks).
      • Specialized mechanisms for host entry (e.g. enzymes in some intestinal parasites).
      • Evasion of host immune system.
      • Increased reproductive capacity.

    Effects of Parasites on Hosts

    • Mechanisms of Parasite Infection: Includes physical damage, obstruction, toxin production, nutrient depletion and/or anemia.
    • Effects of Hosts on Parasites: Genetic predisposition, dietary status, and immune response influence parasitic development and severity of disease.
    • Life Cycle: Explains the various stages of the parasite's life, including infective stages, and definitive and intermediate host.

    Diagnostic Stages and Parasite Groups

    • Diagnostic Stages: Identification of parasite morphology (cysts, trophozoites, eggs, etc.) is crucial, as are laboratory tests.
    • Protozoa:
      • Classification: Sarcodina (amoeba), Mastigophora (flagellates), Ciliata (ciliates), and Apicomplexa (e.g., malaria).
      • Characteristics: Morphological features (e.g. pseudopods, flagella, cilia) and lifecycle are significant for the correct diagnosis.
    • Helminths:
      • Classification: Different phyla like Platyhelminthes (flatworms, including Flukes and Tapeworms), Nematoda (roundworms).
      • Characteristics: Features such as shape (segmented or not), presence of suckers, hooks, and life cycle are important determinants.

    Treatment and Prevention

    • Treatment: Various antiparasitic medications are used to treat infections.
    • Prevention: Methods to reduce the risk of infection, like avoiding contaminated water, food, environments, or vectors are significant.

    Epidemiology

    • Prevalence: The proportion of individuals affected by a disease in a specified population.
    • Incidence: The rate of new cases during a specific timeframe.
    • Endemic disease: A disease that is consistently present in a population.
    • Epidemic disease: A rapid increase in the number of cases of a disease.
    • Distribution patterns: Different methods of transmission, like ingestion, skin penetration, or indirect means, influence patterns.

    Specific Parasites (Examples)

    • Amoeba: Important examples including Entamoeba histolytica are covered
    • Flukes: Life cycle information
    • Tapeworms: Information about their morphology and life cycle
    • Roundworms: Examples, characteristics and life cycle are mentioned. .

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    Explore the fundamental concepts of parasitology in this introductory quiz. Learn about different host types, classifications of parasites based on their relationships with hosts, and their habitats. This quiz will test your understanding of key terms and concepts crucial to understanding parasitology.

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