Paramyxovirus Quiz

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Questions and Answers

What is the type of genome for the Paramyxovirus?

Double stranded RNA

Single stranded Negative Sense RNA (correct)

Double stranded DNA

Single stranded Positive Sense RNA

Where does the Paramyxovirus replicate?

In the nucleus

In the endoplasmic reticulum

In the cytoplasm (correct)

In the mitochondria

What is the mode of transmission for Paramyxovirus?

Vector transmission

Fecal-oral transmission

Respiratory droplets transmission (correct)

Vertical transmission

What is the characteristic rash of Measles?

Maculopapular rash that starts on the head and works down Signup and view all the answers

What is the diagnostic feature of Measles?

Cough, Conjunctivitis, Koplic Signs, and Coryza Signup and view all the answers

What is the complication of Measles that is associated with anti-measles antibodies in the CSF?

Subacute sclerosing panencephalitis Signup and view all the answers

What is the characteristic of the virus that causes multinucleated giant cells?

Fusion proteins Signup and view all the answers

What is the treatment that reduces mortality and complications of Measles?

Vitamin A Signup and view all the answers

Where does the Mumps virus replicate?

In the salivary glands Signup and view all the answers

Which virus is responsible for causing parotitis and orchitis?

Mumps Signup and view all the answers

What is the characteristic of Koplik spots in measles?

Appear 1-2 days after rash and found in buccal mucosa Signup and view all the answers

Which virus causes croup in children?

Parainfluenza virus (PIV) Signup and view all the answers

What is the characteristic of Warthin-Finkeldey cells in measles?

Large multinucleated giant cells Signup and view all the answers

What is the name of the antibody used to treat RSV?

Palivisumab Signup and view all the answers

What is the virulence factor of RSV that causes cells to stick together?

Fusion protein Signup and view all the answers

What is the radiographic sign seen on an X-ray in Croup?

Steeple sign Signup and view all the answers

What is the characteristic of inspiratory stridor in Croup?

A howling noise Signup and view all the answers

What is the name of the drug used to treat RSV in adults?

Ribavirin Signup and view all the answers

Study Notes

Paramyxovirus

Single stranded Negative Sense RNA Virus
Replicates in the cytoplasm (except for Orthomyxovirus)

Measles (Rubeola)

Enveloped virus
Transmission: respiratory droplets
Live MMR vaccine (contraindicated in pregnant women)
Diagnosed with: Cough, Conjunctivitis, Kopliks spots (blueish spots on a red background near the molars on the mucosa), Coryza
Symptoms: fever (up to 104°F), maculopapular rash (starts on the head and works down), confluence rash
Complications: pneumonia, Subacute sclerosing pan encephalitis (SSPE)
Treatment: Vitamin A to reduce mortality and complications

Mumps

Replicates in salivary glands
Causes: parotitis, orchitis (inflammation of epididymis), impaired fertility, testicular atrophy
Meningitis can also occur
Vaccine: MMR Vaccine

Respiratory Syncytial Virus (RSV)

Attaches to G protein to infect respiratory epithelial cells
Causes: bronchiolitis, pneumonia (most common cause in infants)
Virulence factors: fusion protein, syncytium
Treatment: Ribavirin (in adults), Palivizumab (monoclonal antibody)

Parainfluenza

Causes: croup in children (infection/obstruction of upper airways), inspiratory stridor (howling noise)
Radiographic sign: steeple sign on x-ray
Virulence factors: NA, HA, Fusion

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Description

This quiz covers various aspects of Paramyxovirus, including its characteristics, replication, transmission, and diagnosis. It also touches on topics like measles and the MMR vaccine.