Paramyxovirus Quiz

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Questions and Answers

What is the type of genome for the Paramyxovirus?

  • Double stranded RNA
  • Single stranded Negative Sense RNA (correct)
  • Double stranded DNA
  • Single stranded Positive Sense RNA

Where does the Paramyxovirus replicate?

  • In the nucleus
  • In the endoplasmic reticulum
  • In the cytoplasm (correct)
  • In the mitochondria

What is the mode of transmission for Paramyxovirus?

  • Vector transmission
  • Fecal-oral transmission
  • Respiratory droplets transmission (correct)
  • Vertical transmission

What is the characteristic rash of Measles?

<p>Maculopapular rash that starts on the head and works down (A)</p> Signup and view all the answers

What is the diagnostic feature of Measles?

<p>Cough, Conjunctivitis, Koplic Signs, and Coryza (D)</p> Signup and view all the answers

What is the complication of Measles that is associated with anti-measles antibodies in the CSF?

<p>Subacute sclerosing panencephalitis (A)</p> Signup and view all the answers

What is the characteristic of the virus that causes multinucleated giant cells?

<p>Fusion proteins (D)</p> Signup and view all the answers

What is the treatment that reduces mortality and complications of Measles?

<p>Vitamin A (A)</p> Signup and view all the answers

Where does the Mumps virus replicate?

<p>In the salivary glands (D)</p> Signup and view all the answers

Which virus is responsible for causing parotitis and orchitis?

<p>Mumps (D)</p> Signup and view all the answers

What is the characteristic of Koplik spots in measles?

<p>Appear 1-2 days after rash and found in buccal mucosa (D)</p> Signup and view all the answers

Which virus causes croup in children?

<p>Parainfluenza virus (PIV) (A)</p> Signup and view all the answers

What is the characteristic of Warthin-Finkeldey cells in measles?

<p>Large multinucleated giant cells (D)</p> Signup and view all the answers

What is the name of the antibody used to treat RSV?

<p>Palivisumab (A)</p> Signup and view all the answers

What is the virulence factor of RSV that causes cells to stick together?

<p>Fusion protein (B)</p> Signup and view all the answers

What is the radiographic sign seen on an X-ray in Croup?

<p>Steeple sign (A)</p> Signup and view all the answers

What is the characteristic of inspiratory stridor in Croup?

<p>A howling noise (C)</p> Signup and view all the answers

What is the name of the drug used to treat RSV in adults?

<p>Ribavirin (A)</p> Signup and view all the answers

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Study Notes

Paramyxovirus

  • Single stranded Negative Sense RNA Virus
  • Replicates in the cytoplasm (except for Orthomyxovirus)

Measles (Rubeola)

  • Enveloped virus
  • Transmission: respiratory droplets
  • Live MMR vaccine (contraindicated in pregnant women)
  • Diagnosed with: Cough, Conjunctivitis, Kopliks spots (blueish spots on a red background near the molars on the mucosa), Coryza
  • Symptoms: fever (up to 104°F), maculopapular rash (starts on the head and works down), confluence rash
  • Complications: pneumonia, Subacute sclerosing pan encephalitis (SSPE)
  • Treatment: Vitamin A to reduce mortality and complications

Mumps

  • Replicates in salivary glands
  • Causes: parotitis, orchitis (inflammation of epididymis), impaired fertility, testicular atrophy
  • Meningitis can also occur
  • Vaccine: MMR Vaccine

Respiratory Syncytial Virus (RSV)

  • Attaches to G protein to infect respiratory epithelial cells
  • Causes: bronchiolitis, pneumonia (most common cause in infants)
  • Virulence factors: fusion protein, syncytium
  • Treatment: Ribavirin (in adults), Palivizumab (monoclonal antibody)

Parainfluenza

  • Causes: croup in children (infection/obstruction of upper airways), inspiratory stridor (howling noise)
  • Radiographic sign: steeple sign on x-ray
  • Virulence factors: NA, HA, Fusion

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