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Questions and Answers
What is the type of genome for the Paramyxovirus?
What is the type of genome for the Paramyxovirus?
- Double stranded RNA
- Single stranded Negative Sense RNA (correct)
- Double stranded DNA
- Single stranded Positive Sense RNA
Where does the Paramyxovirus replicate?
Where does the Paramyxovirus replicate?
- In the nucleus
- In the endoplasmic reticulum
- In the cytoplasm (correct)
- In the mitochondria
What is the mode of transmission for Paramyxovirus?
What is the mode of transmission for Paramyxovirus?
- Vector transmission
- Fecal-oral transmission
- Respiratory droplets transmission (correct)
- Vertical transmission
What is the characteristic rash of Measles?
What is the characteristic rash of Measles?
What is the diagnostic feature of Measles?
What is the diagnostic feature of Measles?
What is the complication of Measles that is associated with anti-measles antibodies in the CSF?
What is the complication of Measles that is associated with anti-measles antibodies in the CSF?
What is the characteristic of the virus that causes multinucleated giant cells?
What is the characteristic of the virus that causes multinucleated giant cells?
What is the treatment that reduces mortality and complications of Measles?
What is the treatment that reduces mortality and complications of Measles?
Where does the Mumps virus replicate?
Where does the Mumps virus replicate?
Which virus is responsible for causing parotitis and orchitis?
Which virus is responsible for causing parotitis and orchitis?
What is the characteristic of Koplik spots in measles?
What is the characteristic of Koplik spots in measles?
Which virus causes croup in children?
Which virus causes croup in children?
What is the characteristic of Warthin-Finkeldey cells in measles?
What is the characteristic of Warthin-Finkeldey cells in measles?
What is the name of the antibody used to treat RSV?
What is the name of the antibody used to treat RSV?
What is the virulence factor of RSV that causes cells to stick together?
What is the virulence factor of RSV that causes cells to stick together?
What is the radiographic sign seen on an X-ray in Croup?
What is the radiographic sign seen on an X-ray in Croup?
What is the characteristic of inspiratory stridor in Croup?
What is the characteristic of inspiratory stridor in Croup?
What is the name of the drug used to treat RSV in adults?
What is the name of the drug used to treat RSV in adults?
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Study Notes
Paramyxovirus
- Single stranded Negative Sense RNA Virus
- Replicates in the cytoplasm (except for Orthomyxovirus)
Measles (Rubeola)
- Enveloped virus
- Transmission: respiratory droplets
- Live MMR vaccine (contraindicated in pregnant women)
- Diagnosed with: Cough, Conjunctivitis, Kopliks spots (blueish spots on a red background near the molars on the mucosa), Coryza
- Symptoms: fever (up to 104°F), maculopapular rash (starts on the head and works down), confluence rash
- Complications: pneumonia, Subacute sclerosing pan encephalitis (SSPE)
- Treatment: Vitamin A to reduce mortality and complications
Mumps
- Replicates in salivary glands
- Causes: parotitis, orchitis (inflammation of epididymis), impaired fertility, testicular atrophy
- Meningitis can also occur
- Vaccine: MMR Vaccine
Respiratory Syncytial Virus (RSV)
- Attaches to G protein to infect respiratory epithelial cells
- Causes: bronchiolitis, pneumonia (most common cause in infants)
- Virulence factors: fusion protein, syncytium
- Treatment: Ribavirin (in adults), Palivizumab (monoclonal antibody)
Parainfluenza
- Causes: croup in children (infection/obstruction of upper airways), inspiratory stridor (howling noise)
- Radiographic sign: steeple sign on x-ray
- Virulence factors: NA, HA, Fusion
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