18 Questions
What is the type of genome for the Paramyxovirus?
Single stranded Negative Sense RNA
Where does the Paramyxovirus replicate?
In the cytoplasm
What is the mode of transmission for Paramyxovirus?
Respiratory droplets transmission
What is the characteristic rash of Measles?
Maculopapular rash that starts on the head and works down
What is the diagnostic feature of Measles?
Cough, Conjunctivitis, Koplic Signs, and Coryza
What is the complication of Measles that is associated with anti-measles antibodies in the CSF?
Subacute sclerosing panencephalitis
What is the characteristic of the virus that causes multinucleated giant cells?
Fusion proteins
What is the treatment that reduces mortality and complications of Measles?
Vitamin A
Where does the Mumps virus replicate?
In the salivary glands
Which virus is responsible for causing parotitis and orchitis?
Mumps
What is the characteristic of Koplik spots in measles?
Appear 1-2 days after rash and found in buccal mucosa
Which virus causes croup in children?
Parainfluenza virus (PIV)
What is the characteristic of Warthin-Finkeldey cells in measles?
Large multinucleated giant cells
What is the name of the antibody used to treat RSV?
Palivisumab
What is the virulence factor of RSV that causes cells to stick together?
Fusion protein
What is the radiographic sign seen on an X-ray in Croup?
Steeple sign
What is the characteristic of inspiratory stridor in Croup?
A howling noise
What is the name of the drug used to treat RSV in adults?
Ribavirin
Study Notes
Paramyxovirus
- Single stranded Negative Sense RNA Virus
- Replicates in the cytoplasm (except for Orthomyxovirus)
Measles (Rubeola)
- Enveloped virus
- Transmission: respiratory droplets
- Live MMR vaccine (contraindicated in pregnant women)
- Diagnosed with: Cough, Conjunctivitis, Kopliks spots (blueish spots on a red background near the molars on the mucosa), Coryza
- Symptoms: fever (up to 104°F), maculopapular rash (starts on the head and works down), confluence rash
- Complications: pneumonia, Subacute sclerosing pan encephalitis (SSPE)
- Treatment: Vitamin A to reduce mortality and complications
Mumps
- Replicates in salivary glands
- Causes: parotitis, orchitis (inflammation of epididymis), impaired fertility, testicular atrophy
- Meningitis can also occur
- Vaccine: MMR Vaccine
Respiratory Syncytial Virus (RSV)
- Attaches to G protein to infect respiratory epithelial cells
- Causes: bronchiolitis, pneumonia (most common cause in infants)
- Virulence factors: fusion protein, syncytium
- Treatment: Ribavirin (in adults), Palivizumab (monoclonal antibody)
Parainfluenza
- Causes: croup in children (infection/obstruction of upper airways), inspiratory stridor (howling noise)
- Radiographic sign: steeple sign on x-ray
- Virulence factors: NA, HA, Fusion
This quiz covers various aspects of Paramyxovirus, including its characteristics, replication, transmission, and diagnosis. It also touches on topics like measles and the MMR vaccine.
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