Papillomaviridae: Oncogenic Potential

Papillomaviridae can transform cultured cells, leading to oncogenesis.

Papillomaviruses cause papillomas (warts) on the skin and mucous membranes in various animals.

Papillomaviruses typically replicate in the stratified squamous epithelium of the skin and mucous membranes.

In benign warts, Papillomavirus DNA exists as an episome, replicating independently.

When viral DNA integrates into the host genome.

Papillomaviruses are usually benign because the viral DNA remains episomal and is not integrated into the host DNA.

Papillomaviruses are usually species and site specific.

Papillomaviruses may occasionally progress to malignancy depending on specific virus strains.

Cervical carcinoma is associated with Papillomavirus malignancy.

Warts are more commonly seen in cattle than in other animals.