Papillomaviridae and HPV Quiz
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Questions and Answers

What is the diameter of the naked icosahedral capsid of Papillomaviridae?

  • ~55nm (correct)
  • ~100nm
  • ~30nm
  • ~80nm

    • How many open reading frames (ORFs) are present in the Papillomavirus genome?

  • 4-6 ORFs
  • 2-4 ORFs
  • 12-15 ORFs
  • 8-10 ORFs (correct)

    • What is the major cause of cancer in women attributed to some types of human papillomaviruses (HPV)?

  • Uterine cancer
  • Breast cancer
  • Ovarian cancer
  • Cervical carcinoma (correct)

    • Where are the two polyadenylation signals located for viral mRNA transcription in Papillomavirus?

    <p>Downstream of E5</p> Signup and view all the answers

    Which protein of HPV interacts with cell cycle regulatory proteins, particularly retinoblastoma (Rb) protein?

    <p>E6</p> Signup and view all the answers

    What is the main function of E7 protein in HPV infection?

    <p>Inducing cell proliferation</p> Signup and view all the answers

    What is the result of the integration of HPV genome into cellular genome in cancer cells?

    <p>Loss of all viral genes except E6 and E7</p> Signup and view all the answers

    Which region of the viral DNA contains enhancer sequence(s) and is sometimes called URR (upstream regulatory region)?

    <p>LCR (long control region)</p> Signup and view all the answers

    What is the function of E1 protein in HPV infection?

    <p>DNA helicase that unwinds the DNA</p> Signup and view all the answers

    Which proteins are involved in promoting the encapsidation of newly replicated HPV genomes?

    <p>L1 and L2</p> Signup and view all the answers

    What is the function of the late promoter in HPV infection?

    <p>Active in differentiated keratinocytes</p> Signup and view all the answers

    Which cellular protein does HPV E6 associate with to stimulate ubiquitination and degradation of p53?

    <p>E6AP (ubiquitin-protein ligase, aka E3A)</p> Signup and view all the answers

    What happens when HPV genome integrates into different sites in cellular genome in cancer cells?

    <p>Loss of all viral genes except E6 and E7</p> Signup and view all the answers

    What is the function of HPV L2 protein?

    <p>Enhances capsid formation and is involved in encapsidation of viral genome</p> Signup and view all the answers

    What does inhibition of RB lead to in HPV-infected cells?

    <p>Uncontrolled proliferation along with loss of p53’s ability to induce apoptosis</p> Signup and view all the answers

    What is an effective means for reducing cervical cancer deaths according to Section 2.5?

    <p>Pap test combined with DNA test for HPV</p> Signup and view all the answers

    What is the main cause of genital tract cancers associated with oncogenic human papillomaviruses?

    <p>Invasive squamous cell carcinomas</p> Signup and view all the answers

    Which type of cancers can be caused by some types of human papillomaviruses in both men and women?

    <p>Cancers of the anus</p> Signup and view all the answers

    What is the function of E7 protein in HPV infection?

    <p>Stimulates ubiquitination and degradation of p53</p> Signup and view all the answers

    Where are the two polyadenylation signals located for viral mRNA transcription in Papillomavirus?

    <p>Downstream of E5 gene</p> Signup and view all the answers

    Which protein of HPV interacts with cell cycle regulatory proteins, particularly retinoblastoma (Rb) protein?

    <p>E7</p> Signup and view all the answers

    What is the function of the late promoter in HPV infection?

    <p>Activating gene expression in differentiated keratinocytes</p> Signup and view all the answers

    What is the main function of E1 protein in HPV infection?

    <p>Unwinding the viral DNA for replication</p> Signup and view all the answers

    What is the result of the integration of HPV genome into cellular genome in cancer cells?

    <p>Loss of all viral genes except E6 and E7</p> Signup and view all the answers

    What is the function of HPV L2 protein?

    <p>Enhancing capsid formation and promoting encapsidation of viral genome</p> Signup and view all the answers

    What does inhibition of RB lead to in HPV-infected cells?

    <p>Uncontrolled proliferation and loss of p53's ability to induce apoptosis</p> Signup and view all the answers

    What happens when HPV genome integrates into different sites in cellular genome in cancer cells?

    <p>Loss of all viral genes except E6 and E7</p> Signup and view all the answers

    What is an effective means for reducing cervical cancer deaths according to Section 2.5?

    <p>Pap test combined with DNA test for HPV</p> Signup and view all the answers

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