28 Questions
What is the diameter of the naked icosahedral capsid of Papillomaviridae?
~55nm
How many open reading frames (ORFs) are present in the Papillomavirus genome?
8-10 ORFs
What is the major cause of cancer in women attributed to some types of human papillomaviruses (HPV)?
Cervical carcinoma
Where are the two polyadenylation signals located for viral mRNA transcription in Papillomavirus?
Downstream of E5
Which protein of HPV interacts with cell cycle regulatory proteins, particularly retinoblastoma (Rb) protein?
E6
What is the main function of E7 protein in HPV infection?
Inducing cell proliferation
What is the result of the integration of HPV genome into cellular genome in cancer cells?
Loss of all viral genes except E6 and E7
Which region of the viral DNA contains enhancer sequence(s) and is sometimes called URR (upstream regulatory region)?
LCR (long control region)
What is the function of E1 protein in HPV infection?
DNA helicase that unwinds the DNA
Which proteins are involved in promoting the encapsidation of newly replicated HPV genomes?
L1 and L2
What is the function of the late promoter in HPV infection?
Active in differentiated keratinocytes
Which cellular protein does HPV E6 associate with to stimulate ubiquitination and degradation of p53?
E6AP (ubiquitin-protein ligase, aka E3A)
What happens when HPV genome integrates into different sites in cellular genome in cancer cells?
Loss of all viral genes except E6 and E7
What is the function of HPV L2 protein?
Enhances capsid formation and is involved in encapsidation of viral genome
What does inhibition of RB lead to in HPV-infected cells?
Uncontrolled proliferation along with loss of p53’s ability to induce apoptosis
What is an effective means for reducing cervical cancer deaths according to Section 2.5?
Pap test combined with DNA test for HPV
What is the main cause of genital tract cancers associated with oncogenic human papillomaviruses?
Invasive squamous cell carcinomas
Which type of cancers can be caused by some types of human papillomaviruses in both men and women?
Cancers of the anus
What is the function of E7 protein in HPV infection?
Stimulates ubiquitination and degradation of p53
Where are the two polyadenylation signals located for viral mRNA transcription in Papillomavirus?
Downstream of E5 gene
Which protein of HPV interacts with cell cycle regulatory proteins, particularly retinoblastoma (Rb) protein?
E7
What is the function of the late promoter in HPV infection?
Activating gene expression in differentiated keratinocytes
What is the main function of E1 protein in HPV infection?
Unwinding the viral DNA for replication
What is the result of the integration of HPV genome into cellular genome in cancer cells?
Loss of all viral genes except E6 and E7
What is the function of HPV L2 protein?
Enhancing capsid formation and promoting encapsidation of viral genome
What does inhibition of RB lead to in HPV-infected cells?
Uncontrolled proliferation and loss of p53's ability to induce apoptosis
What happens when HPV genome integrates into different sites in cellular genome in cancer cells?
Loss of all viral genes except E6 and E7
What is an effective means for reducing cervical cancer deaths according to Section 2.5?
Pap test combined with DNA test for HPV
Test your knowledge about the Papillomaviridae family and human papillomaviruses (HPV) with this quiz. Learn about the characteristics, hosts, and medical significance of these viruses.
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