Questions and Answers
What is the drug classification of Paliperidone (Invega)?
What is the primary indication for Paliperidone (Invega)?
Schizophrenia
Which of the following are side effects of Paliperidone (Invega)? (Select all that apply)
What nursing responsibilities should be taken into account when administering Paliperidone (Invega)?
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What is the drug action of Paliperidone (Invega)?
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List one contraindication for Paliperidone (Invega).
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What should be cautioned when prescribing Paliperidone (Invega)?
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What type of interactions can occur with Paliperidone (Invega)?
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Study Notes
Paliperidone (Invega) Overview
- Classified as a benzisoxazole antipsychotic, under Category C for pregnancy.
- Administered orally (PO).
Indication
- Primarily indicated for the treatment of schizophrenia.
Side Effects
- Serious risks include neuroleptic malignant syndrome (NMS), tardive dyskinesia (TD), and extrapyramidal symptoms (EPS).
- Common side effects: drowsiness, headache, anxiety, confusion, dizziness, fatigue, and weakness.
- Cardiovascular effects: palpitations, increased/decreased heart rate, and hypotension.
- Gastrointestinal disturbances: abdominal pain, dry mouth, dyspepsia, nausea, and swollen tongue.
- Others include blurry vision, dyspnea, fever, dystonia, akathisia, dyskinesia, and hyperglycemia.
Nursing Responsibilities
- In elderly patients with dementia, use is contraindicated.
- Not recommended for pediatric populations.
- Essential to monitor blood pressure, pulse, ECGs, and cardiovascular symptoms.
- Regularly assess for EPS, TD, NMS, and monitor weight, BMI, fasting blood sugar (FBS), and lipid levels.
- Be vigilant for signs of priapism.
Drug Action
- Functions by antagonizing dopamine and serotonin receptors.
Contraindications
- Avoid use in individuals with hypersensitivity or concurrent medications causing QT prolongation.
- Contraindicated in patients with a history of QT prolongation, cardiac arrhythmias, lower heart rate, hypokalemia, hypomagnesemia, or gastrointestinal narrowing.
Caution
- Use with caution in patients with Parkinson's disease or dementia with Lewy bodies.
- Individuals with a history of suicide attempts or those at risk for aspiration pneumonia require careful monitoring.
- Caution for patients with a history of seizures, conditions increasing temperature, intestinal obstruction, and Reye's syndrome.
- Evaluate risks in patients with brain tumors, diabetes, hepatic impairment, or renal impairment.
Interactions
- CNS depression may be increased with alcohol, antihistamines, sedatives, and opioid analgesics.
- Can antagonize the effects of levodopa or other dopamine agonists.
- Risk of lower blood pressure is heightened when used with antihypertensive agents or nitrates.
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Test your knowledge on Paliperidone (Invega) with these flashcards. Explore its classification, indications, and side effects to better understand this antipsychotic medication. Perfect for students and healthcare professionals alike.
