10 Questions
In which laminae of the dorsal horn do nociceptive axons synapse with second order neurons?
I, II, and V
Which neurotransmitter is released by nociceptive axons for moderate pain?
Glutamate
Which neurotransmitters are released by nociceptive axons during stronger pain?
Glutamate, ATP, and substance P
What type of action is associated with the release of glutamate in the context of nociceptive transmission?
Fast action
Which pair of substances are released by local inhibitory interneurons in the dorsal horn?
GABA and glycine
What is the function of substance P in the dorsal horn?
Neurotransmission of stronger pain
What is the primary function of local inhibitory interneurons in the dorsal horn?
Inhibition of pain transmission
Which lamina of the dorsal horn receives input from nociceptive axons?
Lamina I, II, and V
What is the characteristic of glutamate release in moderate pain transmission?
Fast action
What is released by nociceptive axons in addition to glutamate during stronger pain?
Substance P and ATP
Study Notes
Nociceptive Axons and Synapse
- Nociceptive axons synapse with second-order neurons in the spinal cord, specifically in lamina I, II, and V of the dorsal horn.
Pain Transmission
- Moderate pain: Nociceptive axons release glutamate, which acts fast.
- Stronger pain: Nociceptive axons release glutamate, substance P, and ATP, which have slower and sustained actions.
Local Inhibitory Interneurons
- Release GABA and glycine.
Nociceptive Axons and Synapse
- Nociceptive axons synapse with second-order neurons in the spinal cord, specifically in lamina I, II, and V of the dorsal horn.
Pain Transmission
- Moderate pain: Nociceptive axons release glutamate, which acts fast.
- Stronger pain: Nociceptive axons release glutamate, substance P, and ATP, which have slower and sustained actions.
Local Inhibitory Interneurons
- Release GABA and glycine.
This quiz covers the transmission of pain signals in the spinal cord, including the role of nociceptive axons, second-order neurons, and inhibitory interneurons.
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