Paget's Disease Quiz

Osteitis Deformans

• Osteitis deformans is most common in older adults.

Paget's Disease

• The hallmark feature of the 'burned-out' osteosclerotic stage of Paget's disease is a mixed pattern of bone resorption and formation.
• The most common type of Paget's disease presentation involving multiple bones is polyostotic.
• The enlargement of the facial skeleton seen in Paget's disease is called leontiasis ossea.
• Bisphosphonates are commonly used to suppress mild symptoms of Paget's disease.

Genetics of Paget's Disease

• The SQSTM1 gene mutation is associated with increased osteoclastic activity in Paget's disease.

Fractures

• Stress fractures are the most common type of fracture resulting from a mechanical injury or failure with diminished bone strength.
• Open fractures communicate with the skin surface.
• Fatigue fractures are slow-developing fractures following a period of increased physical activity.
• Comminuted fractures involve fragmentations of the bone.
• Factors that can impede fracture healing include smoking, diabetes, and vitamin D deficiency.

Osteomyelitis

• Pyogenic osteomyelitis is most commonly caused by Staphylococcus aureus.
• Mycobacterium tuberculosis is the cause of 40% of cases of tubercular spondylitis.

Bone Tumors

• Leiomyomas are the most common type of muscle tumor in the uterus and can cause infertility and menorrhagia.
• Embryonal rhabdomyosarcoma develops in the walls of hollow viscera like the urinary bladder or vagina.

Fracture Healing

• A malformed callus that undergoes cystic degeneration and forms a false joint is called a pseudoarthrosis.
• Woven bone is the type of bone initially deposited in the fracture gap during the healing process.

Osteonecrosis (Avascular Necrosis)

• The primary cause of osteonecrosis is interruption of blood supply to the bone.
• The most common cause of mechanical disruption of vessels leading to osteonecrosis is fracture.

Test your knowledge of Paget's disease, also known as osteitis deformans. Learn about the phases of the disease, genetic and environmental factors, and its prevalence in individuals over 40, particularly in the white population.