Paget's Disease Quiz

Osteitis Deformans

• Osteitis deformans is most common in older adults.

Paget's Disease

• The hallmark feature of the 'burned-out' osteosclerotic stage of Paget's disease is a mixed pattern of bone resorption and formation.
• The most common type of Paget's disease presentation involving multiple bones is polyostotic.
• The enlargement of the facial skeleton seen in Paget's disease is called leontiasis ossea.
• Bisphosphonates are commonly used to suppress mild symptoms of Paget's disease.

Genetics of Paget's Disease

• The SQSTM1 gene mutation is associated with increased osteoclastic activity in Paget's disease.

Fractures

• Stress fractures are the most common type of fracture resulting from a mechanical injury or failure with diminished bone strength.
• Open fractures communicate with the skin surface.
• Fatigue fractures are slow-developing fractures following a period of increased physical activity.
• Comminuted fractures involve fragmentations of the bone.
• Factors that can impede fracture healing include smoking, diabetes, and vitamin D deficiency.

Osteomyelitis

• Pyogenic osteomyelitis is most commonly caused by Staphylococcus aureus.
• Mycobacterium tuberculosis is the cause of 40% of cases of tubercular spondylitis.

Bone Tumors

• Leiomyomas are the most common type of muscle tumor in the uterus and can cause infertility and menorrhagia.
• Embryonal rhabdomyosarcoma develops in the walls of hollow viscera like the urinary bladder or vagina.

Fracture Healing

• A malformed callus that undergoes cystic degeneration and forms a false joint is called a pseudoarthrosis.
• Woven bone is the type of bone initially deposited in the fracture gap during the healing process.

Osteonecrosis (Avascular Necrosis)

• The primary cause of osteonecrosis is interruption of blood supply to the bone.
• The most common cause of mechanical disruption of vessels leading to osteonecrosis is fracture.