Paget's Disease

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the most common phase in Paget's disease of bone?

Osteolytic stage

Osteosclerotic stage (correct)

Mixed osteoclastic-osteoblastic stage

Osteoblastic stage

What is the hallmark feature of the sclerotic phase in Paget's disease of bone?

Increased bone porosity

Presence of osteoclasts

Thin cortical bone

Prominent cement lines (correct)

What is the most common type of Paget's disease of bone?

Osteoblastic

Osteolytic

Monostotic

Polyostotic (correct)

What is the characteristic facial feature associated with Paget's disease of bone?

Leonine facies Signup and view all the answers

What is the recommended treatment for Paget's disease of bone with mild symptoms?

Calcitonin and bisphosphonates Signup and view all the answers

What is the most common pathological condition affecting the skeletal system?

Fractures Signup and view all the answers

What type of fracture has a fragmenta'on of bone?

Comminuted Signup and view all the answers

Which fracture type has the overlying skin intact?

Simple Signup and view all the answers

What type of fracture communicates with the skin surface?

Compound Signup and view all the answers

Which type of fracture involves the ends of the bone at the fracture site not being aligned?

Displaced Signup and view all the answers

What is a slow developing fracture that follows a period of increased physical activity called?

Stress fracture Signup and view all the answers

What is the characteristic appearance of bone in the sclerotic phase of Paget's disease?

Mosaic lamellar bone with jig-saw puzzle appearance Signup and view all the answers

Which factor can impede or block fracture healing?

Infection Signup and view all the answers

What is the most common cause of pyogenic osteomyelitis?

Staphylococcus aureus Signup and view all the answers

What is the primary symptom associated with leiomyoma?

Infertility Signup and view all the answers

Where does leiomyosarcoma most commonly develop in adult women?

Retroperitoneum Signup and view all the answers

What is the main characteristic of alveolar rhabdomyosarcoma?

Network of fibrous septae divide the cells into clusters resembling pulmonary alveoli Signup and view all the answers

What is the most common cause of pyogenic osteomyelitis in GI/IV users?

E. coli Signup and view all the answers

What is the primary cause of osteonecrosis (avascular necrosis)?

Vascular injury Signup and view all the answers

What type of fracture repair involves the deposition of woven bone by osteoblasts?

Bony callus Signup and view all the answers

What is the primary cause of mycobacterial osteomyelitis?

Mycobacteria Signup and view all the answers

What is the characteristic feature of pleomorphic leiomyosarcoma subtypes?

Most are fatal Signup and view all the answers

What is the primary symptom associated with leiomyosarcoma in extremities?

Pain Signup and view all the answers

What is the characteristic feature of embryonal rhabdomyosarcoma?

Mimicry of various stages of skeletal muscle differentiation Signup and view all the answers

Study Notes

Paget's Disease of Bone

Most common phase: Sclerotic phase
Hallmark feature of sclerotic phase: Dense, irregular, and disorganized bone formation
Most common type: Monostotic Paget's disease (affects one bone)

Fractures

Comminuted fracture: Fragmentation of bone
Closed fracture: Overlying skin intact
Open fracture: Communicates with skin surface
Displaced fracture: Ends of bone at fracture site not aligned
Stress fracture: Slow-developing fracture following increased physical activity

Bone Characteristics

Sclerotic phase of Paget's disease: Characterized by dense, irregular, and disorganized bone formation

Factors Affecting Fracture Healing

Smoking: Can impede or block fracture healing

Ostemyelitis

Most common cause: Staphylococcus aureus
Most common cause in GI/IV users: Pseudomonas aeruginosa
Primary cause of mycobacterial osteomyelitis: Mycobacterium tuberculosis

Tumors

Leiomyoma: Primary symptom is pain
Leiomyosarcoma: Most commonly develops in the uterus of adult women
Alveolar rhabdomyosarcoma: Characterized by small, round cells
Pleomorphic leiomyosarcoma: Characterized by pleomorphic cells
Embryonal rhabdomyosarcoma: Characterized by embryonal tissue
Leiomyosarcoma in extremities: Primary symptom is pain

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Test your knowledge of Paget's disease, a condition characterized by increased but disordered and structurally unsound bone. This quiz covers the three phases of the disease, genetic and environmental factors, and more.