Paget's Disease
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Questions and Answers

What is the most common phase in Paget's disease of bone?

  • Osteolytic stage
  • Osteosclerotic stage (correct)
  • Mixed osteoclastic-osteoblastic stage
  • Osteoblastic stage
  • What is the hallmark feature of the sclerotic phase in Paget's disease of bone?

  • Increased bone porosity
  • Presence of osteoclasts
  • Thin cortical bone
  • Prominent cement lines (correct)
  • What is the most common type of Paget's disease of bone?

  • Osteoblastic
  • Osteolytic
  • Monostotic
  • Polyostotic (correct)
  • What is the characteristic facial feature associated with Paget's disease of bone?

    <p>Leonine facies</p> Signup and view all the answers

    What is the recommended treatment for Paget's disease of bone with mild symptoms?

    <p>Calcitonin and bisphosphonates</p> Signup and view all the answers

    What is the most common pathological condition affecting the skeletal system?

    <p>Fractures</p> Signup and view all the answers

    What type of fracture has a fragmenta'on of bone?

    <p>Comminuted</p> Signup and view all the answers

    Which fracture type has the overlying skin intact?

    <p>Simple</p> Signup and view all the answers

    What type of fracture communicates with the skin surface?

    <p>Compound</p> Signup and view all the answers

    Which type of fracture involves the ends of the bone at the fracture site not being aligned?

    <p>Displaced</p> Signup and view all the answers

    What is a slow developing fracture that follows a period of increased physical activity called?

    <p>Stress fracture</p> Signup and view all the answers

    What is the characteristic appearance of bone in the sclerotic phase of Paget's disease?

    <p>Mosaic lamellar bone with jig-saw puzzle appearance</p> Signup and view all the answers

    Which factor can impede or block fracture healing?

    <p>Infection</p> Signup and view all the answers

    What is the most common cause of pyogenic osteomyelitis?

    <p>Staphylococcus aureus</p> Signup and view all the answers

    What is the primary symptom associated with leiomyoma?

    <p>Infertility</p> Signup and view all the answers

    Where does leiomyosarcoma most commonly develop in adult women?

    <p>Retroperitoneum</p> Signup and view all the answers

    What is the main characteristic of alveolar rhabdomyosarcoma?

    <p>Network of fibrous septae divide the cells into clusters resembling pulmonary alveoli</p> Signup and view all the answers

    What is the most common cause of pyogenic osteomyelitis in GI/IV users?

    <p>E. coli</p> Signup and view all the answers

    What is the primary cause of osteonecrosis (avascular necrosis)?

    <p>Vascular injury</p> Signup and view all the answers

    What type of fracture repair involves the deposition of woven bone by osteoblasts?

    <p>Bony callus</p> Signup and view all the answers

    What is the primary cause of mycobacterial osteomyelitis?

    <p>Mycobacteria</p> Signup and view all the answers

    What is the characteristic feature of pleomorphic leiomyosarcoma subtypes?

    <p>Most are fatal</p> Signup and view all the answers

    What is the primary symptom associated with leiomyosarcoma in extremities?

    <p>Pain</p> Signup and view all the answers

    What is the characteristic feature of embryonal rhabdomyosarcoma?

    <p>Mimicry of various stages of skeletal muscle differentiation</p> Signup and view all the answers

    Study Notes

    Paget's Disease of Bone

    • Most common phase: Sclerotic phase
    • Hallmark feature of sclerotic phase: Dense, irregular, and disorganized bone formation
    • Most common type: Monostotic Paget's disease (affects one bone)

    Fractures

    • Comminuted fracture: Fragmentation of bone
    • Closed fracture: Overlying skin intact
    • Open fracture: Communicates with skin surface
    • Displaced fracture: Ends of bone at fracture site not aligned
    • Stress fracture: Slow-developing fracture following increased physical activity

    Bone Characteristics

    • Sclerotic phase of Paget's disease: Characterized by dense, irregular, and disorganized bone formation

    Factors Affecting Fracture Healing

    • Smoking: Can impede or block fracture healing

    Ostemyelitis

    • Most common cause: Staphylococcus aureus
    • Most common cause in GI/IV users: Pseudomonas aeruginosa
    • Primary cause of mycobacterial osteomyelitis: Mycobacterium tuberculosis

    Tumors

    • Leiomyoma: Primary symptom is pain
    • Leiomyosarcoma: Most commonly develops in the uterus of adult women
    • Alveolar rhabdomyosarcoma: Characterized by small, round cells
    • Pleomorphic leiomyosarcoma: Characterized by pleomorphic cells
    • Embryonal rhabdomyosarcoma: Characterized by embryonal tissue
    • Leiomyosarcoma in extremities: Primary symptom is pain

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    Description

    Test your knowledge of Paget's disease, a condition characterized by increased but disordered and structurally unsound bone. This quiz covers the three phases of the disease, genetic and environmental factors, and more.

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