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Questions and Answers
What's the equation for DO2?
What's the equation for DO2?
DO2 = Cardiac Output x [(Hgb x SaO2 x 1.34) + (PaO2 x 0.003)] x 10
To understand the essence of DO2, what are the two questions we need to ask?
To understand the essence of DO2, what are the two questions we need to ask?
- How much oxygen is in the blood? 2. How fast is the oxygen being delivered to the tissues?
Remember the amount of gas dissolved in a solution follows ________ law.
Remember the amount of gas dissolved in a solution follows ________ law.
Henry's law
What is the normal DO2?
What is the normal DO2?
What is the normal oxygen extraction?
What is the normal oxygen extraction?
What is the whole body O2 extraction ratio?
What is the whole body O2 extraction ratio?
___________ tells us how many grams per deciliter of oxygen are contained in the blood.
___________ tells us how many grams per deciliter of oxygen are contained in the blood.
What is the solubility coefficient for dissolved oxygen in the blood?
What is the solubility coefficient for dissolved oxygen in the blood?
Myocardial function is determined by what 3 things?
Myocardial function is determined by what 3 things?
What does the Oxygen Carrying Capacity: CaO2 tell you, and what is the reference value?
What does the Oxygen Carrying Capacity: CaO2 tell you, and what is the reference value?
What does Oxygen Delivery: DO2 tell you, and what is the reference value?
What does Oxygen Delivery: DO2 tell you, and what is the reference value?
What does Oxygen Extraction Ratio: EO2 tell you, and what is the reference value?
What does Oxygen Extraction Ratio: EO2 tell you, and what is the reference value?
What does Oxygen Consumption: VO2 tell you, and what is the reference value?
What does Oxygen Consumption: VO2 tell you, and what is the reference value?
What does Venous Oxygen Content: CvO2 tell you, and what is the reference value?
What does Venous Oxygen Content: CvO2 tell you, and what is the reference value?
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Study Notes
Oxygen Delivery Overview
- DO2 equation: DO2 = Cardiac Output x [(Hgb x SaO2 x 1.34) + (PaO2 x 0.003)] x 10
- Brackets signify oxygen carrying capacity (CaO2).
- The factor 10 adjusts units (Hgb in g/dL and CO in L/min).
- Example: If CO = 5 L/min and CaO2 = 20 mL/dL, then DO2 = 1,000 mL O2/min.
Key Questions About DO2
- Essential questions:
- How much oxygen is in the blood?
- How fast is the oxygen being delivered to the tissues?
Gas Dissolution Law
- The amount of gas dissolved in a solution follows Henry's law.
Normal Values
- Normal DO2: 1,000 mL/min
- Normal oxygen extraction: 250 mL/min
- Whole body O2 extraction ratio: 25%.
Oxygen Carrying Capacity
- CaO2 indicates grams of oxygen per deciliter in blood.
- Reference value for CaO2: 20 mL/dL.
Oxygen Delivery Characteristics
- DO2 measures how much O2 is carried in the blood and its delivery speed.
- Reference value for DO2: 1,000 mL/min.
Oxygen Extraction and Consumption
- EO2 reflects how much O2 is extracted by tissues.
- Whole body reference value for EO2: 25%.
- VO2 measures oxygen consumed by tissues at rest.
- Reference value for VO2: 250 mL/min.
Venous Oxygen Content
- CvO2 indicates O2 carried in venous blood.
- Reference value for CvO2: 15 mL/dL.
Myocardial Function Determinants
- Three factors influencing myocardial function:
- Preload
- Afterload
- Contractility.
Solubility of Oxygen
- The solubility coefficient for dissolved oxygen in the blood is 0.003.
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