24.5 Production of Filtrate Within The Renal Corpuscle

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Questions and Answers

What is the relationship between HPg (Hydrostatic Pressure in the glomerulus) and NFP (Net Filtration Pressure)?

  • The relationship is inverse, as an increase in HPg leads to a decrease in NFP. (correct)
  • The relationship is complex, as it depends on other factors not mentioned in the text.
  • The relationship is direct, as an increase in HPg leads to an increase in NFP.
  • The relationship is independent, as HPg and NFP are not related.

What are the two main types of controls that regulate the glomerular filtration rate (GFR)?

  • Reabsorption and excretion regulation
  • Afferent arteriole and efferent arteriole regulation
  • Intrinsic and extrinsic controls (correct)
  • Nervous system and hormonal regulation

Which of the following is an example of an intrinsic control mechanism that regulates GFR?

  • Hormonal regulation
  • Atrial natriuretic peptide
  • Sympathetic nervous system stimulation
  • Renal autoregulation (correct)

What is the effect of sympathetic division stimulation on the glomerular filtration rate (GFR)?

<p>Sympathetic stimulation decreases GFR. (C)</p> Signup and view all the answers

What is the effect of atrial natriuretic peptide (ANP) on the glomerular filtration rate (GFR)?

<p>ANP increases GFR. (C)</p> Signup and view all the answers

Why is the glomerular filtration rate (GFR) tightly regulated?

<p>To control the amount of substances reabsorbed into the blood and excreted in the urine. (C)</p> Signup and view all the answers

Which process involves the movement of solutes from the blood into the tubular fluid?

<p>Tubular secretion (C)</p> Signup and view all the answers

What is the primary purpose of tubular reabsorption?

<p>To return vital solutes and water to the blood (B)</p> Signup and view all the answers

Which statement is true about the relationship between tubular reabsorption and tubular secretion?

<p>They involve the movement of materials in opposite directions (C)</p> Signup and view all the answers

What is the primary purpose of tubular secretion?

<p>To selectively move materials into the tubules for elimination (A)</p> Signup and view all the answers

Which process is primarily responsible for the formation of urine?

<p>All three processes contribute equally (A)</p> Signup and view all the answers

Which of the following statements is true about the relative amounts of tubular reabsorption and tubular secretion?

<p>There is generally more tubular reabsorption than tubular secretion (C)</p> Signup and view all the answers

What is the main effect of increased sympathetic stimulation on the kidneys?

<p>Decreases blood flow into the glomeruli (A)</p> Signup and view all the answers

What is the main purpose of renal autoregulation?

<p>To produce urine at a constant rate despite fluctuations in systemic blood pressure (C)</p> Signup and view all the answers

What is the purpose of the extrinsic controls on glomerular filtration rate described in the text?

<p>To adjust urine output based on physiological need (C)</p> Signup and view all the answers

What are the two mechanisms by which renal autoregulation functions?

<p>Myogenic response and tubuloglomerular feedback (B)</p> Signup and view all the answers

What is the effect of atrial natriuretic peptide (ANP) stimulation on glomerular filtration rate?

<p>Increases GFR through vasodilation of the afferent arteriole (C)</p> Signup and view all the answers

What is the range of mean arterial pressure (MAP) over which renal autoregulation is effective?

<p>80-180 mm Hg (A)</p> Signup and view all the answers

What is the primary mechanism by which sympathetic stimulation decreases GFR?

<p>Decreased blood flow into the glomeruli due to vasoconstriction of the afferent arteriole (D)</p> Signup and view all the answers

How does the myogenic response contribute to renal autoregulation?

<p>By causing vasoconstriction in response to decreased blood pressure (D)</p> Signup and view all the answers

How does the tubuloglomerular feedback mechanism contribute to renal autoregulation?

<p>By decreasing the filtration surface area in response to increased blood pressure (B)</p> Signup and view all the answers

What is the physiological stimulus that triggers increased sympathetic stimulation of the kidneys?

<p>Exercise or emergency situations (C)</p> Signup and view all the answers

How does the intrinsic and extrinsic control mechanisms of GFR differ?

<p>Intrinsic controls maintain GFR within normal limits, while extrinsic controls change GFR to adjust urine output (B)</p> Signup and view all the answers

What is the purpose of the figures in the text?

<p>To demonstrate the role of the myogenic response and tubuloglomerular feedback in renal autoregulation (A)</p> Signup and view all the answers

What happens to the amount of substances in the tubular fluid when the filtrate amount increases?

<p>They increase (D)</p> Signup and view all the answers

What is the role of macula densa cells in the nephron?

<p>Measure NaCl levels in the tubular fluid (A)</p> Signup and view all the answers

How does an increase in glomerular hydrostatic pressure (HPg) affect substances in the tubular filtrate?

<p>Substances increase (B)</p> Signup and view all the answers

What is the significance of an increase in NFP (Net Filtration Pressure) on substances in the tubular fluid?

<p>More substances remain (A)</p> Signup and view all the answers

How does a decrease in HPg affect substances in the tubular filtrate?

<p>Substances decrease (C)</p> Signup and view all the answers

What is the role of the JG apparatus in monitoring filtrate formation?

<p>Monitor the amount of filtrate formed (B)</p> Signup and view all the answers

What is the effect on the value of NFP if HPg decreases from 65 mm Hg to 55 mm Hg?

<p>The NFP decreases (D)</p> Signup and view all the answers

What role do the macula densa cells play in the regulation of blood pressure in the glomerulus?

<p>Indirectly measure blood pressure in the glomerulus through NaCl levels (B)</p> Signup and view all the answers

How does an increase in glomerular hydrostatic pressure (HPg) affect the rate of reabsorption in the tubules?

<p>Increases the rate of reabsorption (D)</p> Signup and view all the answers

How are NaCl levels in tubular fluid related to glomerular hydrostatic pressure (HPg)?

<p>NaCl levels increase as HPg increases (B)</p> Signup and view all the answers

If the amount of filtrate formed increases, what is the likely effect on NaCl levels in the tubular fluid?

<p>NaCl levels increase (D)</p> Signup and view all the answers

What happens to NFP if glomerular hydrostatic pressure (HPg) and capsular hydrostatic pressure (HPc) both increase by 5 mm Hg each?

<p>NFP increases by 5 mm Hg (A)</p> Signup and view all the answers

What is the effect of sympathetic stimulation on mesangial cells?

<p>Induces contraction (A)</p> Signup and view all the answers

How does atrial natriuretic peptide (ANP) affect the afferent arteriole?

<p>Causes vasodilation (C)</p> Signup and view all the answers

What is the function of angiotensin II in the context of GFR?

<p>Causes a decrease in GFR (B)</p> Signup and view all the answers

How does atrial natriuretic peptide (ANP) impact glomerular filtration rate (GFR)?

<p>Increases GFR (A)</p> Signup and view all the answers

What adjustments allow the body to conserve fluid under conditions of sympathetic activation?

<p>Contraction of mesangial cells and vasoconstriction of afferent arteriole (A)</p> Signup and view all the answers

What triggers the release of atrial natriuretic peptide (ANP) from atrial cardiac muscle cells?

<p>Distension of atrial chambers due to increased blood volume return or blood pressure (A)</p> Signup and view all the answers

What type of proteins are generally not filtered across the filtration membrane?

<p>Negatively charged proteins (D)</p> Signup and view all the answers

Where is the filtrate caught before being funneled into the proximal convoluted tubule?

<p>Renal corpuscle (B)</p> Signup and view all the answers

Which function do mesangial cells perform in the kidney related to filtration membrane?

<p>Phagocytize macromolecules (B)</p> Signup and view all the answers

What happens to substances that are not filtered across the filtration membrane?

<p>They exit through the efferent arteriole (C)</p> Signup and view all the answers

How are substances like antigen-antibody complexes removed from the basement membrane?

<p>By phagocytosis of mesangial cells (C)</p> Signup and view all the answers

What can damage the filtration membrane according to the text?

<p>Certain diseases and heavy metals (C)</p> Signup and view all the answers

Which substances are freely filtered through the glomerular filtration membrane?

<p>Water, glucose, amino acids, and small ions (D)</p> Signup and view all the answers

What happens to substances that are not filtered through the glomerular filtration membrane?

<p>They remain in the blood plasma (C)</p> Signup and view all the answers

What is the primary function of mesangial cells in the glomerulus?

<p>To phagocytize or remove debris from the glomerulus (B)</p> Signup and view all the answers

What is the approximate daily volume of filtrate produced by the kidneys?

<p>180 L (B)</p> Signup and view all the answers

What property of the glomerular filtration membrane prevents large proteins from being filtered?

<p>Both the negative charge and small openings (A)</p> Signup and view all the answers

Which of the following substances would be considered filtered in a limited way by the glomerulus?

<p>Hormones (B)</p> Signup and view all the answers

What is the primary effect of atrial natriuretic peptide (ANP) on the glomerular filtration rate (GFR)?

<p>Increases GFR by relaxing the mesangial cells (C)</p> Signup and view all the answers

What is the primary purpose of the tubuloglomerular feedback mechanism in renal autoregulation?

<p>To maintain GFR within a normal range (B)</p> Signup and view all the answers

According to the information provided, over what range of mean arterial pressure (MAP) is renal autoregulation effective?

<p>80-180 mmHg (A)</p> Signup and view all the answers

What is the primary mechanism by which sympathetic stimulation decreases the glomerular filtration rate (GFR)?

<p>Constriction of the afferent arteriole (C)</p> Signup and view all the answers

What is the main purpose of the extrinsic controls on glomerular filtration rate (GFR) described in the text?

<p>To regulate fluid balance and blood volume (A)</p> Signup and view all the answers

What is the primary mechanism by which renal autoregulation maintains the glomerular filtration rate (GFR) when mean arterial pressure (MAP) decreases?

<p>Vasodilation of the afferent arteriole (D)</p> Signup and view all the answers

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