Overview of the Immune Response
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Questions and Answers

Which of the following is NOT an external defense of the innate immune system?

  • Sweat
  • Mucous membranes
  • Stomach acid (correct)
  • Skin
  • The complement system is primarily involved in the recognition of microbial patterns.

    False (B)

    What role do natural killer cells play in the immune response?

    Surveillance and killing of infected or cancerous cells

    The _____ is a defense mechanism that speeds up the activity of white blood cells and slows down viral replication.

    <p>fever</p> Signup and view all the answers

    Match the immune defenses with their descriptions:

    <p>Phagocytes = Cells that 'eat' foreign matter Inflammation = Attracts white blood cells to the area Natural killer cells = Surveillance and killing Defensins = Antimicrobial peptides produced by cells</p> Signup and view all the answers

    What function do opsonins serve in the immune system?

    <p>They facilitate phagocytosis. (A)</p> Signup and view all the answers

    The complement system consists of approximately 10 serum proteins.

    <p>False (B)</p> Signup and view all the answers

    What are CD molecules and why are they important?

    <p>CD molecules are cell surface markers that help in identifying cells based on their membrane expression.</p> Signup and view all the answers

    Tissue damage caused by microbial toxins is an example of _____ tissue damage.

    <p>microbe-induced</p> Signup and view all the answers

    Match the following immune system responses to their descriptions:

    <p>Formation of opsonins = Facilitates phagocytosis Acute inflammation = Neutrophils leave the bloodstream Cell lysis = Kills extracellular microbes Microbial toxins = Cause tissue damage</p> Signup and view all the answers

    Which of the following is primarily responsible for the humoral immune response?

    <p>B lymphocytes (A)</p> Signup and view all the answers

    Innate immunity is specific and develops over a person's lifetime.

    <p>False (B)</p> Signup and view all the answers

    What type of immune memory is created from adaptive immune responses?

    <p>Memory cells</p> Signup and view all the answers

    The _____ response of immunity involves immediate action against infections and is antigen-independent.

    <p>innate</p> Signup and view all the answers

    Match the immune system players with their functions:

    <p>T lymphocytes = Helper and killer cells B lymphocytes = Produce antibodies Memory cells = Stored for future pathogen recognition Natural killer cells = Attack abnormal cells directly</p> Signup and view all the answers

    What is the primary function of cytokines in the immune response?

    <p>To communicate between cells (A)</p> Signup and view all the answers

    The adaptive immune response provides immediate maximal response.

    <p>False (B)</p> Signup and view all the answers

    What is the role of the immune system in surveillance?

    <p>To watch for signs of damage or disease</p> Signup and view all the answers

    Which organ is NOT a part of the immune system?

    <p>Liver (C)</p> Signup and view all the answers

    Cytokines only have one specific function in the immune response.

    <p>False (B)</p> Signup and view all the answers

    What does the term 'antigen' refer to?

    <p>A substance that reacts with the products of a specific immune response.</p> Signup and view all the answers

    The __________ system includes proteins that enhance the ability of antibodies and phagocytic cells to clear microbes and damaged cells.

    <p>complement</p> Signup and view all the answers

    Match the following components of the immune system with their functions:

    <p>Antibodies = Neutralize pathogens Cytokines = Cell-to-cell communication Complement proteins = Opsonization and lysis of pathogens Chemokines = Induce chemotaxis in leukocytes</p> Signup and view all the answers

    Which type of white blood cells are specifically involved in the identification and response to antigens?

    <p>Lymphocytes (D)</p> Signup and view all the answers

    Chemokines and cytokines are the same and can be used interchangeably.

    <p>False (B)</p> Signup and view all the answers

    Name one type of effector molecule involved in the immune response.

    <p>Antibodies or cytokines or complement proteins</p> Signup and view all the answers

    Flashcards

    Innate Immune Response

    The body's first line of defense against pathogens, using non-specific methods to fight off infection.

    Physical Barriers (Innate)

    External defenses like skin, mucus membranes, and fluids that prevent pathogens from entering the body.

    Phagocytes (Innate)

    White blood cells that engulf and destroy pathogens.

    Inflammation (Innate)

    A process that recruits white blood cells to the site of infection and helps prevent spread of infection

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    Complement System (Innate)

    A group of proteins in the blood that help destroy pathogens by damaging pathogen membranes.

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    Adaptive Immune Response

    A specific immune response that develops over time, targeting particular invaders.

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    Antigen-independent response

    A response to an infection without prior exposure to the specific pathogen.

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    Antigen-dependent response

    Immune response that specifically targets the pathogen after exposure to the pathogen.

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    Immune System Surveillance

    The immune system's continuous monitoring of the body for signs of damage or disease.

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    Lymphocytes

    Specialized immune cells involved in the adaptive immune response.

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    Cellular Communication

    Immune cells communicating with each other using various chemical signals.

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    Effector Response

    The immune system's targeted attack on the identified threat.

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    Immune System Components

    The immune system is made up of cells, tissues/organs, and effector molecules that work together to fight infections and diseases.

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    Antigen

    A substance that triggers an immune response. It can be from microbes, or from other sources.

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    Cytokines

    Low-molecular weight proteins that are secreted by cells and regulate immune response by coordinating communication between immune cells.

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    Chemokines

    Cytokines that attract immune cells to areas of infection or inflammation.

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    CD Molecules

    Surface proteins on cells that help identify cell type. Different cells have unique mixtures of CD molecules.

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    Effector Molecules

    Molecules that carry out the actions of the immune response (e.g., complement proteins, antibodies).

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    T cells

    A type of lymphocyte that plays a critical role in cell-mediated immunity.

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    Cell surface molecules

    Proteins on a cell's surface used to identify the cell type

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    Complement System

    A group of proteins in the blood that fight infection.

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    Opsonins

    Proteins that help immune cells eat bacteria.

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    Acute Inflammation

    Immune response where white blood cells enter tissues.

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    Cell lysis

    Destruction of cells by the immune system.

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    Study Notes

    Overview of the Immune Response

    • The immune system is a complex biological system that protects the body from harmful pathogens.
    • Pathogens include viruses, toxins, carcinogens, fungi, bacteria, germs, and parasites.
    • The immune system has two main branches: innate and adaptive immunity.

    Innate (Non-Specific) Immunity

    Physical, Biochemical and Microbial Barriers

    • External Defenses include skin, mucus membranes, hairs (cilia), sweat, tears, urine, and commensal bacteria.
    • Internal Defenses include stomach acid, digestive enzymes, chemicals released from damaged tissues (defensins, interferons, lysozyme, histamine).

    Cellular and Protein Defenses

    • Cells recognize microbial patterns (PAMPs) through cell receptors (PRRs).
    • Phagocytes engulf and destroy foreign matter.
    • Natural killer cells monitor and eliminate foreign cells.
    • Complement system: lysis of pathogens.
    • Inflammation: attracts white blood cells to the infected area and prevents spread of infection.
    • Fever: speeds up white blood cell activity and slows down viral replication.

    Adaptive (Specific) Immunity (Cell-mediated Responses)

    • Adaptive Immunity develops later and requires activation of lymphocytes.
    • B lymphocytes mature in bone marrow and produce antibodies.
    • T lymphocytes mature in the thymus and have helper, killer, and suppressor roles.
    • Memory cells are crucial for faster responses to subsequent encounters with the same pathogen.

    Innate and Adaptive Immune Responses

    • Innate immunity provides the initial defense (1st and 2nd line).
    • Adaptive immunity develops later (3rd line).
    • Innate immunity includes epithelial barriers, phagocytes, dendritic cells, NK cells, and complement system.
    • Adaptive immunity involves B lymphocytes that produce antibodies and T lymphocytes for cell-mediated responses.
    • Immune responses take place over hours to days.

    Innate vs Adaptive Responses

    • Innate immunity: non-specific, present from birth, immediate maximal response, no immunological memory.
    • Adaptive immunity: specific, develops over a lifetime, antigen dependent, lag time before maximal response, immunological memory.

    How Our Immune System Provides Defense

    • Surveillance/Detection: watches the body for signs of damage and patterns.
    • Communication: cell-to-cell contact, chemical messengers (cytokines, chemokines).
    • Elicit effector response: attacking antigens and sometimes self antigens (autoimmunity).
    • Resolution and Memory: resolution of problems detected. Memory is only in adaptive responses.

    Major Players in the Immune System

    • Cells: white blood cells (leukocytes)
    • Tissues/Organs: skin, bone marrow, thymus, lymph nodes, spleen, MALT/GALT
    • Effector Molecules: complement system proteins, cytokines, antibodies, others.

    Components of the Immune System

    • Lymph nodes: recognize and eliminate pathogens
    • Respiratory system: moves mucus and contaminants
    • Spleen: assists the body in protecting itself against bacterial infections
    • Stomach and intestines: stomach acid kills harmful bacteria; antibodies attack pathogens.
    • Skin: forms a barrier against pathogens
    • Other listed cell groups and their roles

    Immune System Recognition of Antigens

    • Antigens: substances that react with the immune system and trigger a response.
    • Neoplastic or normal host cells, microbial proteins and carbohydrates, environmental factors (pollen, animal dander).

    How Our Immune System Communicates: Cytokines

    • Cytokines are low-molecular-weight proteins secreted by various cell types.
    • Involved in cell-to-cell communication, coordinate antibody and T cell responses, and amplify immune reactivity.
    • Include colony-stimulating factors (CSF), interferons (IFN), interleukins (IL), and lymphokines, which are secreted by lymphocytes.

    How Our Immune System Communicates: Chemokines

    • Important to note: chemokines are a type of cytokine.
    • Chemokines are low-molecular-weight proteins that induce chemotaxis (movement) or chemokinesis (increased motility) in leukocytes.
    • They function as regulators of the immune system.

    How to Identify a Cell: CD Molecules

    • CD Molecules (Clusters of Differentiation) are cell surface proteins used to identify cell types.
    • Identified in vitro (test tube) and in vivo (living organism).

    The Complement System (Aka Complement)

    • Series of ~30 serum proteins.
    • Activated sequentially after infection.
    • Leads to formation of opsonins (proteins that enhance phagocytosis), acute inflammation, and cell lysis, killing extracellular microbes.

    Immune Activation Can Result in Tissue Damage

    • Tissue damage can be caused by the microbe itself, cell lysis by microbes, microbial toxins, and host inflammatory responses.

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    Description

    Explore the essential components and functions of the immune system in this quiz. Understand the distinctions between innate and adaptive immunity, as well as the various barriers and cellular defenses that protect the body from pathogens. Test your knowledge on how the body responds to infections and foreign substances.

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