Outcomes of Acute and Chronic Inflammation

Complete restoration of the site of acute inflammation to normal, involving the removal of cellular debris and microbes by macrophages, and resorption of edema fluid by lymphatics.

The outcome of acute inflammation when there is substantial tissue destruction, tissues incapable of regeneration or abundant fibrin exudation.

The process of resolution of inflammatory exudates by fibrosis, where connective tissue grows into the area of damage or exudate, converting it into a mass of fibrous tissue.

A type of chronic inflammation characterized by the accumulation of macrophages and lymphocytes.

A specific type of chronic inflammation characterized by the formation of granulomas, which are collections of macrophages and other cells that surround a central core of foreign material.

Prolonged inflammation lasting weeks or months, involving simultaneous inflammation, tissue destruction, and healing processes.

A type of chronic inflammation where the accumulation of macrophages and lymphocytes is the dominant feature, without the formation of granulomas.

The process of switching from acute inflammation to chronic inflammation, often triggered by persistent stimuli or a failure to resolve the initial inflammatory response.

Chronic inflammation arising from repeated bouts of acute inflammation, or sustained exposure to a persistent irritant.

Chronic inflammation arising from a persistent infectious agent, such as certain bacteria or viruses, that continuously triggers the immune response.

Chronic inflammation arising from hypersensitivity reactions, such as autoimmune diseases, where the immune system attacks the body's own tissues.

Chronic inflammation arising from prolonged exposure to harmful substances in the environment or within the body, like silica dust or high levels of lipids.

An immune response to persistent antigens, involving macrophage transformation to epithelioid cells and multinucleated giant cells, often with central caseous necrosis. The prototypical example is a tubercle formed by the tuberculosis bacillus.

A buildup of macrophages and lymphocytes that form small, nodular structures to encapsulate foreign bodies, like sutures or talc, that cannot be easily phagocytosed by a single macrophage.

The formation of granulomas, which are collections of macrophages and other immune cells that wall off persistent antigens or foreign material. It's a common feature of chronic inflammation.

A systemic response to inflammatory stimuli, involving fever, increased acute-phase protein production, and other systemic changes. It's the body's way of fighting serious infection or injury.

The systemic response to inflammation, including fever, changes in blood protein production, and altered immune function. It's essentially the body's overall reaction to an inflammatory event.

Substances that induce prostaglandin synthesis in the hypothalamus, leading to fever. They trigger the body's temperature control center to increase heat.

A group of plasma proteins, mainly produced by the liver, that increase significantly in response to inflammation. They're part of the body's complex strategy to combat infection or injury.