36 Questions
Which cell type is the dominant cell type activated in chronic inflammation?
Macrophages
What is a characteristic feature of granuloma formation?
Contains the injurious agent and attempts to eradicate it
What type of granuloma is typically seen with tuberculosis (TB)?
Caseating granuloma
Which of the following is NOT a systemic sign associated with chronic inflammation?
Elevated white blood cell count
What is the main function of plasma cells in chronic inflammation?
Producing antibodies
Which of the following is a feature of chronic inflammation that distinguishes it from acute inflammation?
Fibrosis and tissue destruction
Which of the following best describes chronic inflammation?
May occur without acute inflammation and involves simultaneous injury and healing
What are the main causes of chronic inflammation according to the text?
Persistent infection by microorganisms, autoimmune diseases, prolonged exposure to toxic agents
Which cells are involved in the infiltration during chronic inflammation?
Macrophages, lymphocytes, and plasma cells
What is a key feature of the morphology of chronic inflammation?
Tissue destruction and attempts at healing by connective tissue replacement
How does chronic inflammation differ from acute inflammation?
Prolonged duration and might not exhibit the classic signs of acute inflammation
What are some systemic effects of chronic inflammation according to the text?
Impaired wound healing
Chronic inflammation is always preceded by acute inflammation.
False
The morphology of chronic inflammation involves infiltration of eosinophils and neutrophils.
False
Chronic inflammation lasts for a short duration, typically days to weeks.
False
Angiogenesis and fibrosis are key features of the morphology of acute inflammation.
False
Chronic inflammation can only occur due to persistent infection by microorganisms.
False
Chronic inflammation is always characterized by the 5 classic signs of acute inflammation.
False
Eosinophils are the dominant cell type activated in chronic inflammation.
False
Granuloma formation can only be caused by infectious organisms such as TB and leprosy.
False
During chronic inflammation, the main function of lymphocytes is to directly kill injurious agents.
False
Tissue necrosis is not associated with chronic inflammation.
False
Angiogenesis is a common change observed in acute inflammation.
False
Macrophage-lymphocyte interactions are not involved in granuloma formation in chronic inflammation.
False
Chronic inflammation is always characterized by the 5 classic signs of acute inflammation.
False
Granuloma formation can only be caused by infectious organisms such as TB and leprosy.
False
Macrophage-lymphocyte interactions are not involved in granuloma formation in chronic inflammation.
False
Angiogenesis is a common change observed in acute inflammation.
False
During chronic inflammation, the main function of lymphocytes is to directly kill injurious agents.
False
The morphology of chronic inflammation involves infiltration of eosinophils and neutrophils.
False
Macrophages are not the dominant cell type activated in chronic inflammation.
False
Granuloma formation is only associated with infectious organisms and not with autoimmune conditions.
False
Eosinophils play a minor role in chronic inflammation compared to neutrophils.
True
Tissue necrosis is not a common feature associated with chronic inflammation.
False
Angiogenesis is not observed as a change in chronic inflammation.
False
Plasma cells in chronic inflammation mainly act through direct killing of injurious agents.
False
Study Notes
- Chronic inflammation is a condition where inflammation persists for months or years, either following acute inflammation or without it.
- Unlike acute inflammation, chronic inflammation is not characterized by the five signs of inflammation: redness, heat, swelling, pain, and loss of function.
- Chronic inflammation is marked by the infiltration of mononuclear cells, including macrophages, lymphocytes, plasma cells, and other immune cells, into the affected tissue.
- Macrophages are the dominant cell type in chronic inflammation, producing substances that can cause tissue damage and fibrosis.
- Lymphocytes produce cytokines and contribute to the immune response in chronic inflammation.
- In chronic inflammation, fibroblasts proliferate and cause fibrosis, leading to structural destruction and replacement of damaged tissue.
- Granulomas, a special type of chronic inflammation, form in response to persistent inflammatory stimuli and can contain the injurious agent and attempt to eradicate it.
- Granulomas can be caused by persistent infections, such as tuberculosis, leprosy, and syphilis, or exposure to exogenous materials like asbestos and silica.
- Chronic inflammation is associated with systemic signs, including low-grade fever, weight loss, and anemia.
Test your knowledge on the concept and causes of chronic inflammation, processes involved, morphology, systemic effects, and main outcomes. Learn about chronic inflammation and its impact on health.
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