OS 230: Pharmacology Toxicity Notes

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Questions and Answers

What is the mechanism of action of minocycline?

  • Binds to calcium and iron (correct)
  • Deposits in teeth
  • Stains skin during long-term use
  • Inhibits COX-2

Which drug is known to cause staining of the skin with prolonged use?

  • Opioids
  • Cocaine
  • Tetracycline (correct)
  • Aspirin

What effect do oral contraceptives have on endometrial and ovarian cancers?

  • Decrease in endometrial and ovarian cancers (correct)
  • Inducing endometrial and ovarian cancers
  • Increase in endometrial and ovarian cancers
  • No effect on endometrial and ovarian cancers

Which condition can occur due to chronic aspirin toxicity?

<p>Prolonged bleeding (B)</p> Signup and view all the answers

What is the main effect of COX-1 inhibition by nonselective NSAIDs like aspirin?

<p>Prolonged bleeding (D)</p> Signup and view all the answers

What can happen when ammonia passes the blood-brain barrier due to aspirin ingestion?

<p>Encephalopathy (A)</p> Signup and view all the answers

Which type of injury results in complete epithelium loss?

<p>Abrasion (B)</p> Signup and view all the answers

'Saddle nose' deformity can result from the abuse of which substance?

<p>Cocaine (B)</p> Signup and view all the answers

What is the main cause of a puncture wound?

<p>A long and narrow object (A)</p> Signup and view all the answers

Which cells are more susceptible to radiation damage?

<p>Cells with open chromatin (B)</p> Signup and view all the answers

Which vitamin is essential for proper blood clotting?

<p>Vitamin K (C)</p> Signup and view all the answers

What is a potential side effect of taking warfarin, a vitamin K antagonist?

<p>Prolonged bleeding (C)</p> Signup and view all the answers

Which vitamin deficiency is common in alcoholics?

<p>Vitamin B1 (thiamine) (D)</p> Signup and view all the answers

What is a potential consequence of iodine deficiency?

<p>Goiter (C)</p> Signup and view all the answers

What is the body mass index (BMI) cutoff for obesity?

<p>BMI ≥ 30 (D)</p> Signup and view all the answers

Which hormone is secreted from adipocytes to suppress appetite?

<p>Leptin (B)</p> Signup and view all the answers

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