OS 230: Environmental Diseases - Xenobiotics and Drug Metabolization
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Questions and Answers

Which enzyme family is most important in phase I drug metabolization?

  • Kinase
  • Isomerase
  • Ligase
  • P-450 (correct)

What is the main function of phase 2 drug metabolization?

  • Turn into water soluble compounds for excretion (correct)
  • Detoxification
  • Formation of DNA-binding metabolites
  • Activation into active compounds

Which chemical is known to have carcinogenic properties and is found in cigarette smoke?

  • Nitrogen dioxide
  • Benzo[a]pyrene (BaP) (correct)
  • Ozone
  • Sulfur dioxide

What does excessive lead uptake by bones and developing teeth cause?

<p>Microcytic hypochromic anemia with basophilic stippling of red blood cells (B)</p> Signup and view all the answers

Which heavy metal is considered if it has a density 5 times that of water?

<p>Lead (C)</p> Signup and view all the answers

What color do the skin and mucous membranes turn when exposed to carbon monoxide poisoning?

<p>Cherry red (A)</p> Signup and view all the answers

Which enzyme family catalyzes the reactions in phase I drug metabolization?

<p>P-450 (D)</p> Signup and view all the answers

'Burton’s line' in the bones and gingiva is formed as a result of excessive exposure to which heavy metal?

<p>Lead (C)</p> Signup and view all the answers

What effect does chronic alcohol consumption have on the liver?

<p>Fatty liver (D)</p> Signup and view all the answers

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