OS 230: Environmental Diseases - Xenobiotics and Drug Metabolization
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Questions and Answers

Which enzyme family is most important in phase I drug metabolization?

  • Kinase
  • Isomerase
  • Ligase
  • P-450 (correct)
  • What is the main function of phase 2 drug metabolization?

  • Turn into water soluble compounds for excretion (correct)
  • Detoxification
  • Formation of DNA-binding metabolites
  • Activation into active compounds
  • Which chemical is known to have carcinogenic properties and is found in cigarette smoke?

  • Nitrogen dioxide
  • Benzo[a]pyrene (BaP) (correct)
  • Ozone
  • Sulfur dioxide
  • What does excessive lead uptake by bones and developing teeth cause?

    <p>Microcytic hypochromic anemia with basophilic stippling of red blood cells</p> Signup and view all the answers

    Which heavy metal is considered if it has a density 5 times that of water?

    <p>Lead</p> Signup and view all the answers

    What color do the skin and mucous membranes turn when exposed to carbon monoxide poisoning?

    <p>Cherry red</p> Signup and view all the answers

    Which enzyme family catalyzes the reactions in phase I drug metabolization?

    <p>P-450</p> Signup and view all the answers

    'Burton’s line' in the bones and gingiva is formed as a result of excessive exposure to which heavy metal?

    <p>Lead</p> Signup and view all the answers

    What effect does chronic alcohol consumption have on the liver?

    <p>Fatty liver</p> Signup and view all the answers

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