Orthomyxoviridae

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Questions and Answers

What does the name Orthomyxovirus mean?

  • Correct mucus (correct)
  • Sticky virus
  • Mutating virus
  • Influenza virus

How many genera are included in the Orthomyxoviridae family?

  • 3
  • 5
  • 7 (correct)
  • 9

Match the genera to the virus associated with it:

Alphainfluenzavirus = Influenza A virus Betainfluenza virus = Influenza B virus Gammainfluenzavirus = Influenza C virus Delta influenza virus = Influenza C

Which genus contains tick-borne viruses that infect livestock and humans?

<p>Thogotovirus (B)</p> Signup and view all the answers

Which genus contains the infectious salmon anemia virus?

<p>Isavirus (C)</p> Signup and view all the answers

What is the genome structure of orthomyxoviruses?

<p>6-8 segments of linear Single-stranded, negative-sense RNA (B)</p> Signup and view all the answers

The genome of orthomyxoviruses is segmented

<p>True (A)</p> Signup and view all the answers

Which of the following statements about morphology and genome type of Orthomyxoviruses is FALSE?

<p>Are 80-120 mm at there smallest dimension (C)</p> Signup and view all the answers

What makes influenza viruses sensitive to heat and acidic pH?

<p>Lipid envelope (A)</p> Signup and view all the answers

What are the two types of glycoprotein spikes for influenza A and B?

<p>Homotrimer HA and homotetramer NA</p> Signup and view all the answers

Influenza C lacks neuraminidase and has only two types of glycoprotein spikes

<p>False (B)</p> Signup and view all the answers

Isavirus has hemagglutinin esterase and F protein

<p>True (A)</p> Signup and view all the answers

The lipid envelop of influenza A viruses are derived from?

<p>Derived from the host cell</p> Signup and view all the answers

What key components are found in the envelope of the Influenza A virus?

<p>Hemagglutinin (HA), Neuraminidase (NA), and Matrix Protein 2 (M2) (A)</p> Signup and view all the answers

The M1 matrix protein lies beneath the lipid layer of the Influenza A virus

<p>True (A)</p> Signup and view all the answers

What distinguishes genetic shift from genetic drift in orthomyxoviruses?

<p>Drift involves point mutations, while shift involves reassortment (B)</p> Signup and view all the answers

How are influenza viruses named?

<p>Based on their hemagglutinin and neuraminidase subtypes (C)</p> Signup and view all the answers

How many hemaglutinin and neuraminidase subtypes of influenzas viruses are there, respectively ?

<p>18 hemagglutinin and 11 neuraminidase subtypes</p> Signup and view all the answers

Match the transmission to the species associated with it

<p>Fecal-oral (common) = Aquatic birds Ingestion and inhalation = Poultry Aersols, droplets and fomites = Mammals Ticks = Ticks and mammals (Thogotoviruses)</p> Signup and view all the answers

Isavirus may be transmitted in water, gills being the important route

<p>True (A)</p> Signup and view all the answers

Which virus was first identified as the cause of equine influenza in 1956?

<p>A/Equine/Prague/1/56 (H7N7) (A)</p> Signup and view all the answers

Equine influenza viruses are the most important viral respiratory disease of horses

<p>True (A)</p> Signup and view all the answers

Equine influenza viruses have been reported worldwide in which animals?

<p>Horses, donkeys and mules</p> Signup and view all the answers

What is the most common pathological effect of influenza virus replication in the respiratory tract?

<p>Ciliated epithelial cell destruction (B)</p> Signup and view all the answers

Equine influenza virus replicates in the URT only

<p>False (B)</p> Signup and view all the answers

What are the common symptoms of a primary infection of equine influenza?

<p>Laryngitis (A), Tracheitis (B), Bronchitis (C), Alveolar edema (D)</p> Signup and view all the answers

What are the symptoms associated with a secondary infection of equine influenza virus?

<p>Fever, nasal discharge, and dry cough (B)</p> Signup and view all the answers

What are the clinical features of equine influenza virus?

<p>High morbidity, rare mortality, rapid spread (D)</p> Signup and view all the answers

What is the potential clinical manifestation of a pregnant mare who has a prolonged fever?

<p>Abortion</p> Signup and view all the answers

If there are no complications with equine influenza virus, the infection is self limiting and the animals who were infected remain infectious at least 5 days after clinical signs

<p>True (A)</p> Signup and view all the answers

Which of the following horses are at high risk of infection with equine influenza virus?

<p>Racehorses (A), Breeding stock (B), Show jumpers (C), Horses sent to sales (D)</p> Signup and view all the answers

Equids are the ONLY source of equine influenza virus

<p>True (A)</p> Signup and view all the answers

What are the primary diagnostic methods for equine influenza?

<p>RT-PCR and virus isolation (B)</p> Signup and view all the answers

How can equine influenza virus be detected in chicken embryos?

<p>Observation of hemagglutination in the Atlantic and amniotic fluids (A)</p> Signup and view all the answers

Which of the following prevention and control methods is FALSE?

<p>Vaccinate with subunit vaccines (C)</p> Signup and view all the answers

Why are pigs considered a "mixing vessel" for influenza viruses?

<p>Their respiratory epithelial cells contain receptors for both avian and mammalian influenza viruses, allowing reassortment. (B)</p> Signup and view all the answers

Pigs possess both human (SAα2,6Gal) and avian (SAα2,3Gal) receptors

<p>True (A)</p> Signup and view all the answers

Which swine influenza virus subtype has been historically predominant in pigs?

<p>H1N1 (A)</p> Signup and view all the answers

What is the primary transmission route of swine influenza virus among pigs?

<p>Aerosolized droplets and direct contact (C)</p> Signup and view all the answers

The swine influenza virus replicates in the lower respiratory tract

<p>False (B)</p> Signup and view all the answers

What is the primary route of transmission for swine influenza virus?

<p>Aerosols (D)</p> Signup and view all the answers

Which of the following pathological changes is associated with swine influenza virus infection in the lungs?

<p>Airway plugging, peribronchial and perivascular mononuclear cell infiltration (A)</p> Signup and view all the answers

What is the typical incubation period for swine influenza virus in pigs?

<p>24-72 hours (C)</p> Signup and view all the answers

What is a common clinical sign observed in pigs infected with swine influenza virus?

<p>Fever ≥42°C (D)</p> Signup and view all the answers

Under which of the following conditions is swine influenza virus infection typically non-fatal in pigs?

<p>Animals are kept warm and stress free (B)</p> Signup and view all the answers

When is the optimal time frame for collecting samples to identify swine influenza virus after the onset of clinical signs?

<p>24-48 hours (D)</p> Signup and view all the answers

Which type of sample is recommended for virus identification in diagnosing swine influenza?

<p>Deep nasal swab (A)</p> Signup and view all the answers

Which of the following methods can be used to detect swine influenza virus?

<p>Inoculation of embryonated chicken eggs (B)</p> Signup and view all the answers

What diagnostic assay detects type A influenza viruses?

<p>Enzyme-linked immunosorbent assay (ELISA) (B)</p> Signup and view all the answers

If deep nasal swabs are collected from pigs suspected of having swine influenza, what is the next step in confirming the diagnosis according to the content?

<p>Inoculating the sample into embryonated chicken eggs for HI testing (B)</p> Signup and view all the answers

What is the scientific basis for using embryonated chicken eggs to detect swine influenza virus?

<p>The virus replicates efficiently in the cells of embryonated chicken eggs. (A)</p> Signup and view all the answers

What change in antibody titre between paired sera samples collected 10-21 days apart indicates a recent swine influenza virus infection using the Hemagglutination Inhibition (HI) test?

<p>A four-fold or greater increase (C)</p> Signup and view all the answers

Why are molecular methods, like RT-PCR, valuable tools in diagnosing swine influenza?

<p>They directly detect the presence of the viral RNA. (B)</p> Signup and view all the answers

Which group of pathogens are important to consider in the differential diagnosis of acute respiratory disease in pigs?

<p>PRRS virus infection (A), Bordetella bronchiseptica (B), Mycoplasma hyopneumonia (C), Actinobacillus pleuropneumoniae (D)</p> Signup and view all the answers

Why is cross-protection against new subtypes a major drawback of commercially available swine influenza vaccines?

<p>Vaccines do not consistently protect against emerging variants. (A)</p> Signup and view all the answers

What is the primary economic impact of swine influenza outbreaks on pig farming?

<p>Losses arising from the requirement to cull infected pigs (D)</p> Signup and view all the answers

Considering the limitations of current swine influenza vaccines, what is a crucial aspect of effective control strategies?

<p>Rapid diagnostics and biosecurity measures to prevent spread (C)</p> Signup and view all the answers

Why is it important to collect paired sera samples 10-21 days apart when performing HI tests for swine influenza?

<p>To detect the initial antibody response and the peak antibody titre following infection (C)</p> Signup and view all the answers

In the context of swine influenza diagnostics, what is the primary advantage of RT-PCR over serological tests like HI?

<p>RT-PCR can detect active infection earlier (D)</p> Signup and view all the answers

How does the genetic diversity of swine influenza viruses impact the effectiveness of current vaccination strategies?

<p>High diversity means vaccines need frequent updates to match circulating strains (B)</p> Signup and view all the answers

What would be the MOST appropriate next step after obtaining a positive RT-PCR result for swine influenza on a pig farm?

<p>Submit samples to a reference laboratory for subtyping and genetic characterization. (A)</p> Signup and view all the answers

In what way does the ability of swine influenza virus to cause economic losses differ from diseases where therapeutic options are available?

<p>The losses are greater as there are no therapeutic options besides culling (D)</p> Signup and view all the answers

How does the need for culling in swine influenza outbreaks DIRECTLY impact the economic viability of a pig farm?

<p>Culling removes potentially productive animals from the herd (A)</p> Signup and view all the answers

What is the MOST important factor to consider when selecting a commercial vaccine for swine influenza in a particular region?

<p>The degree of homology between the vaccine strain and the circulating field strains (B)</p> Signup and view all the answers

What aspect of swine influenza virus makes it particularly challenging to eradicate from a pig farm once an outbreak has occurred?

<p>The potential for asymptomatic carriers to maintain the virus within the herd (D)</p> Signup and view all the answers

When was the infection in chickens referred to as 'fowl plague' first recognized?

<p>1878, in Northern Italy. (C)</p> Signup and view all the answers

Why are avian influenza viruses considered economically important?

<p>Because of the costs associated with eliminating infected bird populations. (A)</p> Signup and view all the answers

What mortality rate defines an avian influenza virus as 'Notifiable AI (NAI)'?

<p>At least 75% mortality. (B)</p> Signup and view all the answers

How are avian influenza viruses categorized for international trade reasons?

<p>As either high or low pathogenicity (HPAI or LPAI). (A)</p> Signup and view all the answers

What subtypes of influenza A virus are specifically used to define Notifiable AI (NAI)?

<p>H5 and H7. (C)</p> Signup and view all the answers

What is the overarching classification that includes Highly Pathogenic Notifiable Avian Influenza (HPNAI) and Low Pathogenicity Notifiable Avian Influenza (LPNAI)?

<p>Notifiable AI (NAI). (C)</p> Signup and view all the answers

Where does the influenza virus replicate in birds?

<p>In the intestinal and respiratory tracts</p> Signup and view all the answers

What is the primary pathological outcome of viremia caused by avian influenza virus?

<p>Multifocal lymphoid and visceral organ necrosis (C)</p> Signup and view all the answers

Which clinical feature is highly characteristic of chickens infected with Highly Pathogenic Avian Influenza (HPAI) within the first 48 hours?

<p>Sudden death without apparent symptoms (B)</p> Signup and view all the answers

What are the common clinical signs observed in poultry infected with Low Pathogenicity Avian Influenza (LPAI)?

<p>Cessation of egg production and facial edema. (D)</p> Signup and view all the answers

Why is clinical diagnosis of avian influenza considered challenging?

<p>Clinical signs are highly variable and overlap with other diseases. (A)</p> Signup and view all the answers

What is the initial step in laboratory testing for avian influenza (AI) detection?

<p>RT-PCR to detect the matrix protein (M) gene. (A)</p> Signup and view all the answers

After a sample tests positive for the matrix protein (M) gene via RT-PCR, what is the subsequent step in avian influenza diagnosis?

<p>Testing for specific H5 and H7 genes. (C)</p> Signup and view all the answers

Why is sequence analysis of the H gene performed after confirming the presence of H5 or H7 genes in avian influenza diagnosis?

<p>To determine the cleavage sites, which relate to pathogenicity. (B)</p> Signup and view all the answers

For what specific purpose is virus isolation from cloacal swabs primarily used in the context of avian influenza diagnosis?

<p>To identify the specific strain of the virus via sequence analysis. (D)</p> Signup and view all the answers

Which diagnostic assays are most commonly used for avian influenza detection?

<p>Agar gel immunodiffusion, ELISA, and Haemagglutination inhibition assay. (B)</p> Signup and view all the answers

What is the primary strategy for controlling avian influenza outbreaks?

<p>Surveillance, biosecurity, and depopulation. (B)</p> Signup and view all the answers

What biosecurity measure is crucial in preventing the spread of avian influenza to poultry farms?

<p>Segregating poultry from wild birds. (B)</p> Signup and view all the answers

Why is vaccination not widely used to control Highly Pathogenic Avian Influenza (HPAI) in many developed countries?

<p>Vaccination can mask infection and hinder surveillance efforts. (D)</p> Signup and view all the answers

What is the purpose of conducting sequence analysis of the H gene following a positive test for H5 or H7 genes?

<p>To identify cleavage sites. (C)</p> Signup and view all the answers

If a diagnostic test for avian influenza is positive for H5, what is the next diagnostic step?

<p>To perform sequence analysis of the H gene (D)</p> Signup and view all the answers

Bovine influenza is caused by bovine influenza B virus

<p>True (A)</p> Signup and view all the answers

Which of the following are clinical signs of bovine influenza?

<p>All of the above (D)</p> Signup and view all the answers

Additional clinical signs of bovine influenza virus are coughing, sneezing and breathing difficulties

<p>True (A)</p> Signup and view all the answers

Sudden or unexplained deaths in bovine with bovine influenza are quite common

<p>False (B)</p> Signup and view all the answers

Flashcards

Orthomyxovirus meaning

Means 'correct mucus'.

Genera in Orthomyxoviridae

There are 7 genera included in the Orthomyxoviridae family.

Thogotovirus

Contains tick-borne viruses that infect livestock and humans.

Isavirus

Contains the infectious salmon anemia virus.

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Orthomyxovirus genome

6-8 segments of linear Single-stranded, negative-sense RNA

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Influenza sensitivity

Influenza viruses are sensitive to heat and acidic pH due to their lipid envelope.

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Glycoprotein spikes (A, B)

Homotrimer HA and homotetramer NA are the two types of glycoprotein spikes for influenza A and B.

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Isavirus proteins

Isavirus has hemagglutinin esterase and F protein.

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Influenza A envelope origin

The lipid envelope of influenza A viruses is derived from the host cell.

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Key components in Influenza A envelope

Hemagglutinin (HA), Neuraminidase (NA), and Matrix Protein 2 (M2).

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Genetic shift vs. drift

Drift involves point mutations, while shift involves reassortment of gene segments.

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Influenza virus naming

Based on their hemagglutinin and neuraminidase subtypes.

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Influenza subtypes (H, N)

There are 18 hemagglutinin and 11 neuraminidase subtypes of influenza viruses.

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Isavirus transmission

Isavirus may be transmitted in water, with gills being the important route of entry in fish.

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First equine influenza virus

A/Equine/Prague/1/56 (H7N7) was first identified as the cause of equine influenza in 1956.

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Equine influenza significance

Equine influenza viruses are the most important viral respiratory disease of horses.

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Equine influenza hosts

Equine influenza viruses have been reported worldwide in horses, donkeys, and mules.

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Influenza pathological effect

Ciliated epithelial cell destruction is the most common pathological effect of influenza virus replication in the respiratory tract.

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Primary equine influenza symptom

Laryngitis is a common symptom of a primary infection of equine influenza.

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Secondary equine influenza symptoms

Fever, nasal discharge, and dry cough.

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Equine influenza features

High morbidity, rare mortality, rapid spread.

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Pregnant mare influenza risk

Abortion is a potential clinical manifestation of a pregnant mare with a prolonged fever.

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Equine influenza diagnosis

RT-PCR and virus isolation are the primary diagnostic methods for equine influenza.

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Pigs as 'mixing vessels'

Their respiratory epithelial cells contain receptors for both avian and mammalian influenza viruses, allowing reassortment.

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Pig influenza receptors

Pigs possess both human (SAα2,6Gal) and avian (SAα2,3Gal) receptors.

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Predominant swine flu

H1N1 has been historically predominant in pigs.

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Swine flu transmission

Aerosolized droplets and direct contact is how swine influenza virus is primarily transmitted among pigs.

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Swine Influenza Virus Transmission

A highly contagious virus spread through the air.

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Swine Flu Replication Site

Upper respiratory tract.

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Swine Flu Incubation

Short, typically 24-72 hours.

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Swine Flu Fever

42°C or higher.

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Swine Flu Sample Collection

Collect samples within 24–48 hours of symptom onset; deep nasal swabs are recommended.

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Swine Flu: Onset

Sudden outbreak of symptoms in multiple animals.

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Swine Flu Diagnosis: HI Test

A test using chicken eggs to detect the virus using hemagglutination inhibition (HI).

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Swine Flu: Pathological Features

Airway blockage and immune cell infiltration.

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Hemagglutination Inhibition (HI) Test

A serological test used to detect swine influenza virus antibodies in paired sera.

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RT-PCR in SIV Diagnosis

Molecular methods used for diagnosis, particularly real-time and conventional methods.

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Differential Diagnosis of Swine Respiratory Disease

Acute respiratory disease in pigs can be caused by infections with PRRS virus, Aujeszky’s disease virus, Porcine circovirus type 2, APP, Bordetella bronchiseptica, Pasteurella multocida, and Mycoplasma hyopneumoniae.

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Swine Influenza Vaccines

Commercial vaccines either whole virus (inactivated and adjuvanted). Major drawback in that they do not consistently confer cross-protection against new subtypes

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Economic Impact of Swine Influenza

Swine influenza viruses are economically important due to losses arising from the requirement to cull infected pigs

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Paired Sera

Collecting two serum samples from an animal over a period of time to observe changes in antibody levels.

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Avian Influenza

Also known as 'fowl plague,' it's a highly contagious viral disease in birds, especially chickens, causing significant economic losses.

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Pathogenicity (AI)

Classifies avian influenza viruses based on their ability to cause disease in poultry for international trade regulations.

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Notifiable Avian Influenza (NAI)

An infection of poultry caused by any influenza A virus of the H5 or H7 subtype, or any AI virus that causes at least 75% mortality.

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Highly Pathogenic Notifiable Avian Influenza (HPNAI)

A notifiable avian influenza that causes severe disease and high mortality in poultry.

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Low Pathogenicity Notifiable Avian Influenza (LPNAI)

A notifiable avian influenza that causes mild disease in poultry.

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Notifiable disease

Avian influenza is a disease that must be reported to authorities due to its potential impact on poultry and trade.

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HPAI symptoms

Caused by a highly virulent strain; can result in sudden death, or cessation of egg production, lacrimation, diarrhea, edema, cyanosis or torticollis.

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Pathogenesis of Avian Influenza

Viremia leads to necrosis in lymphoid and visceral organs, including pancreatitis, myocarditis, myositis, encephalitis, and hemorrhage.

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Clinical Features of LPAI

May cause considerable losses due to decreased egg production.

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Diagnosis of Avian Influenza

The basis of diagnosis is laboratory testing to detect matrix protein (M) gene via RT-PCR, followed by specific H5 and H7 gene testing.

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Control measures for Avian Influenza

Surveillance, biosecurity, and depopulation upon HPAI detection; segregation from wild birds.

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Avian Influenza: Diagnostic Steps

RT-PCR identifies presence of the virus. Sequence analysis determines cleavage sites.

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Control of Avian Influenza

Surveillance efforts, improved biosecurity, and population reduction.

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Study Notes

  • Swine influenza virus is highly contagious and spreads through aerosols.

Pathogenesis

  • The virus replicates in the upper respiratory tract.
  • Airway plugging, peribronchial, and perivascular mononuclear cell infiltration occurs.
  • Bronchopneumonia may develop.

Symptoms

  • The incubation period is short, lasting 24-72 hours.
  • The disease often appears in many animals simultaneously.
  • High fever (≥42°C) is a key symptom.
  • Nasal discharge occurs in later stages.
  • The disease is typically not fatal if animals are kept warm and stress-free.

Diagnosis

  • Diagnosis is based on the sudden onset of clinical symptoms.
  • Virus identification requires sample collection within 24–48 hours after the appearance of clinical signs.
  • Deep nasal swabs are recommended for sample collection.
  • Virus identification can be done by inoculating embryonated chicken eggs.
  • A hemagglutination inhibition (HI) test is used for detection.
  • Enzyme-linked immunosorbent assays (ELISA) may be available for detection of type A influenza viruses.
  • Hemagglutination Inhibition (HI) test is performed in primary serological tests for detection of swine influenza virus antibodies on paired sera.
  • Collection of paired sera is generally recommended 10-21 days apart.
  • A four-fold or greater increase in titre between the first and second sample is suggestive of a recent infection.
  • Molecular methods - particularly RT-PCR (both real time and conventional) are used.

Differential Diagnosis

  • Acute respiratory disease in pigs can be caused by PRRS virus infection.
  • Aujeszky’s disease virus can cause acute respiratory disease in pigs.
  • Porcine circovirus type 2 can cause acute respiratory disease in pigs.
  • Actinobacillus pleuropneumoniae can cause acute respiratory disease in pigs.
  • Bordetella bronchiseptica can cause acute respiratory disease in pigs.
  • Pasteurella multocida can cause acute respiratory disease in pigs.
  • Mycoplasma hyopneumoniae can cause acute respiratory disease in pigs.

Control

  • No feasible therapeutic options exist for swine influenza.
  • Commercial vaccines currently available are either whole virus, inactivated and are adjuvanted.
  • These vaccines have a major drawback in that they do not consistently confer cross-protection against new subtypes.
  • Swine influenza viruses are economically important due to losses arising from the requirement to cull infected pigs.

Avian Influenza Virus

  • Avian influenza virus can cause a devastating infection in chickens referred to as "fowl plague".
  • Fowl plague was recognized in 1878 in Northern Italy.
  • The virus was later isolated in 1901 but identified as avian influenza (AI) in 1955.
  • Avian influenza viruses are economically important due to losses arising from the requirement to eliminate infected birds.
  • Avian influenza viruses are categorized for international trade reasons as high or low pathogenicity (HPAI or LPAI).
  • Notifiable AI (NAI) is an infection of poultry caused by any influenza A virus of the H5 or H7 subtype or any AI virus that causes at least 75% mortality.
  • NAI viruses are divided as highly pathogenic notifiable avian influenza (HPNAI) and low pathogenicity notifiable avian influenza (LPNAI).
  • Avian influenza is a notifiable disease.

Pathogenesis of Avian Influenza Virus

  • Viremia leads to multifocal lymphoid and visceral organ necrosis.
  • Pathogenesis includes pancreatitis, myocarditis, myositis, encephalitis, and hemorrhage.

Clinical Features of HPAI

  • A highly virulent strain of AI can cause sudden death without symptoms.
  • Beyond 48 hours of HPAI symptoms may be present.

Clinical Features of LPAI

  • May cause considerable losses due to decreased egg production.
  • Symptoms include cessation of egg production, lacrimation, diarrhea, edema of the face, head, and neck, cyanosis of combs or wattles, and torticollis.

Diagnosis of Avian Influenza

  • Clinical diagnosis is difficult due to variability in clinical signs.
  • RT-PCR is used in laboratory testing to detect the matrix protein (M) gene, which is highly conserved in all strains of AI viruses; a positive result indicates avian influenza.
  • Specific H5 and H7 genes are tested following a positive result for the matrix protein.
  • If positive for H5 or H7, sequence analysis of the H gene is performed to determine cleavage sites.
  • Virus isolation from cloacal swabs is done only for obtaining material used for sequence analysis.
  • Agar gel immunodiffusion, ELISA and hemagglutination inhibition assay can also be used in testing.

Control of Avian Influenza

  • Surveillance, biosecurity, and depopulation are implemented when HPAI viruses are detected.
  • Segregating poultry from wild birds helps control the spread.
  • Vaccination has not been used to control HPAI in most developed countries.

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