Podcast
Questions and Answers
Which of the following is a substrate used in the production of nicotinic acid?
Which of the following is a substrate used in the production of nicotinic acid?
- 4-Picoline
- Salol
- Pyramidonum
- 3-Picoline (correct)
What type of reaction is used to obtain substituted derivatives of isonicotinic acid from 4-picoline?
What type of reaction is used to obtain substituted derivatives of isonicotinic acid from 4-picoline?
- Oxidation
- Esterification (correct)
- Reduction
- Hydrolysis
Salicylamide is best described as which of the following?
Salicylamide is best described as which of the following?
- Salt of salicylic acid
- Amide of salicylic acid (correct)
- Ether of salicylic acid
- Ester of salicylic acid
Which of the following reagents is reacted with 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one to synthesize Pyramidonum?
Which of the following reagents is reacted with 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one to synthesize Pyramidonum?
In the synthesis of derivatives of pyrazolidinedione, what are the primary starting materials?
In the synthesis of derivatives of pyrazolidinedione, what are the primary starting materials?
Luminal, a derivative of barbituric acid, is synthesized through the condensation of diethyl ester with which other reactant?
Luminal, a derivative of barbituric acid, is synthesized through the condensation of diethyl ester with which other reactant?
What is the immediate precursor in the synthesis of p-nitrofenetol?
What is the immediate precursor in the synthesis of p-nitrofenetol?
Which compound is typically used as the starting material for synthesizing derivatives of p-aminophenol?
Which compound is typically used as the starting material for synthesizing derivatives of p-aminophenol?
What is the starting material for the production of derivatives of p-aminobenzoic acid?
What is the starting material for the production of derivatives of p-aminobenzoic acid?
What is the role of pyridine in the condensation of ASC or p-chlorosulfonylphenylurethane with amines to produce sulfonamides?
What is the role of pyridine in the condensation of ASC or p-chlorosulfonylphenylurethane with amines to produce sulfonamides?
Which class of compounds serves as the substrate for most sulfonamide syntheses?
Which class of compounds serves as the substrate for most sulfonamide syntheses?
2-aminothiazole, a key intermediate in the synthesis of sulfathiazole, can be synthesized from which of the following?
2-aminothiazole, a key intermediate in the synthesis of sulfathiazole, can be synthesized from which of the following?
What other reactant is needed to produce Benactizin from benzaldehyde?
What other reactant is needed to produce Benactizin from benzaldehyde?
Which compound is a key intermediate in the synthesis of 1,1-diphenylo-2-piperydynopropanol (Jessical)?
Which compound is a key intermediate in the synthesis of 1,1-diphenylo-2-piperydynopropanol (Jessical)?
What happens to phenylacetic acid to get phenylacetylonitrile?
What happens to phenylacetic acid to get phenylacetylonitrile?
Esters of which acid are key intermediates in the synthesis of Methylphenidate?
Esters of which acid are key intermediates in the synthesis of Methylphenidate?
Amphetamine is synthesized from which of the following?
Amphetamine is synthesized from which of the following?
In the synthesis of Bemegride, what is a key starting material?
In the synthesis of Bemegride, what is a key starting material?
Which type of substituted benzene is a precursor to ethacridine lactate production?
Which type of substituted benzene is a precursor to ethacridine lactate production?
What is the role of chlorosulfonic acid in saccharin synthesis?
What is the role of chlorosulfonic acid in saccharin synthesis?
Flashcards
Nicotinic Acid Substrates
Nicotinic Acid Substrates
Substrates for obtaining nicotinic acid and its derivatives include picoline, quinoline bases, quinoline, 3-picoline, 5-ethyl-2-methylpyridine, and nicotine; oxidation with sodium or potassium permanganate.
Ethyl Nicotinate Synthesis
Ethyl Nicotinate Synthesis
Reacting 3-picoline with sulfuric acid yields nicotinic acid which then reacts with ethanol to form ethyl nicotinate.
Uses of ethyl nicotinate
Uses of ethyl nicotinate
Ethyl nicotinate reacts with diethylamide to form nicetamid, or with ethanolamine, to form cholamid
Isonicotinic Acid Synthesis
Isonicotinic Acid Synthesis
Signup and view all the flashcards
Salol Synthesis
Salol Synthesis
Signup and view all the flashcards
Creation of salicylic acid
Creation of salicylic acid
Signup and view all the flashcards
PAS Synthesis
PAS Synthesis
Signup and view all the flashcards
Pyrazolone Derivatives
Pyrazolone Derivatives
Signup and view all the flashcards
Antipyrine Synthesis
Antipyrine Synthesis
Signup and view all the flashcards
Pyrazolidinedione Synthesis
Pyrazolidinedione Synthesis
Signup and view all the flashcards
Barbituric Acid Synthesis
Barbituric Acid Synthesis
Signup and view all the flashcards
Veronal
Veronal
Signup and view all the flashcards
p-Aminophenol Derivatives
p-Aminophenol Derivatives
Signup and view all the flashcards
p-Aminophenol Substrate
p-Aminophenol Substrate
Signup and view all the flashcards
Study Notes
- These are study notes on various organic compounds and their synthesis, including pyridine derivatives, salicylic acid derivatives, pyrazolone derivatives, pyrazolidinedione derivatives, barbituric acid derivatives, p-aminophenol derivatives, p-aminobenzoic acid derivatives, sulfonamides, diphenylmethane derivatives, and others.
Pyridinecarboxylic Acid Derivatives
- Includes nicotinic acid amide, diethylamide nicotinic acid, and hydroxymethylamide nicotinic acid.
- Substrates for obtaining nicotinic acid and its derivatives: picoline, quinoline bases, ethyl-methylpyridine, and oxidation using potassium permanganate.
- Isonicotinic acid derivatives are obtained from 4-picoline.
Salicylic Acid Derivatives
- Salicylic acid derivatives are produced using the Kolbe-Schmitt method.
- Includes phenyl salicylate, methyl salicylate, salicylamide.
- PAS is para-aminosalicylic acid, which is 4-amino-2-hydroxybenzoic acid.
Pyrazolone and Pyrazolidinedione Derivatives
- Includes 1,5-dimethyl-2-phenylpyrazol-3-one (Antipyrine) and 1,5-dimethyl-4-dimethylamino-2-phenylpyrazol-3-one (Pyramidone).
- Starting materials are derivatives of pyrazolone-3 with ethyl acetoacetate and phenyllhydrazine.
- Includes the synthesis of Antipyrine and Pyramidone from 1,5-dimethyl-2-phenyl-4-nitrosopyrazol-3-one.
- Pyrazolidynodionu: Starting with esters derived from malonic acids.
- Includes 2,4-diphenylpyrazolidine-3,5-dione, which is Osadryn and 4-butyl-1,2-diphenylpyrazolidine-3,5-dione, which is Butapirazol.
Barbituric Acid Derivatives
- Obtained by condensing diethyl esters of appropriately substituted malonic acids with urea.
- Includes Veronal, which is diethylbarbituric acid, and Luminal.
p-Aminophenol Derivatives
- Synthesis typically uses p-nitrophenol, obtained from benzene which undergoes the process of nitrosation and oxidation of the resulting nitrosol.
- Includes p-acetylaminopheol and paracetamol and p-phenetidine.
p-Aminobenzoic Acid Derivatives
- p-Nitrotoluene is used to produce p-aminobenzoic acid derivatives.
- Derivatives can be obtained through: oxidation to p-nitrobenzoic acid derivatives or reducing p-nitrotoluene to p-toluidine.
- Examples include ethyl p-aminobenzoate (Anesthesin) and procaine.
Sulfonamides
- Substrate for synthesizing sulfa drugs is chlorosulfonic acid, used on acetanilide to produce p-acetylaminobenzenesulfonyl chloride (ASC).
- ASC or chlorosulfonylurethane is condensed with amines.
- Includes sulfanilamide.
- Derivatives: sulfacetamide
- Contains 2-(p-aminobenzenesulfonamido) pyridine (sulfapyridine).
CD (Sulfonamides Continued)
- 2-sulfanilamidothiazole (sulfathiazole).
- Prepared using ASC, which is hydrolyzed partially in a previous acetylated step.
- Reacting with 2-aminotiazole
- Guanidine sulfanilamide (sulfaguanidine).
Diphenylmethane Derivatives
- Synthesis
- Chlorohydrate of diethylaminoethylic ester of benzilic acid - Benactyzine. substrate for the production of benzilic acid is benzaldehyde
- Chlorohydrate of diethylaminoethylic ester of diphenylacetic kwasu- Vegantin.
- Diethylaminoethylic ester for vegatnin, adiphanine, difectil, spasmolitin.
- Morazone, pyrisal, are precursors for Diphenylmethane
Related molecules
- 1,1-diphenyl-2-piperydynopropaned-Tussucal - starting chlorochloride propionylu
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
