Podcast
Questions and Answers
Which step in the halogenation of benzene is considered the rate-determining step?
Which step in the halogenation of benzene is considered the rate-determining step?
- Addition of Cl to FeCl3 (correct)
- Formation of σ Complex
- Generation of Cl radical
- Formation of FeCl4-
What is the role of the catalyst in the Friedel-Crafts Alkylation reaction?
What is the role of the catalyst in the Friedel-Crafts Alkylation reaction?
- Speed up the formation of the electrophile (correct)
- Convert the methyl chloride to toluene
- Prevent the reaction from occurring
- Catalyze the formation of toluene
Which species acts as a Lewis acid in the halogenation mechanism?
Which species acts as a Lewis acid in the halogenation mechanism?
- FeCl4-
- HCl
- FeCl3 (correct)
- Cl radical
What is the product of nitration of nitrobenzene?
What is the product of nitration of nitrobenzene?
What is the purpose of H2SO4 in the sulphonation of benzene?
What is the purpose of H2SO4 in the sulphonation of benzene?
What is the major disadvantage of Friedel-Crafts alkylation with respect to polyalkylation?
What is the major disadvantage of Friedel-Crafts alkylation with respect to polyalkylation?
Which step involves the formation of a σ Complex during SE aromatic substitution?
Which step involves the formation of a σ Complex during SE aromatic substitution?
Why do benzene rings with strong deactivating groups like NO2, SO3H, CHO, or COOH not undergo Friedel-Crafts alkylation?
Why do benzene rings with strong deactivating groups like NO2, SO3H, CHO, or COOH not undergo Friedel-Crafts alkylation?
In Friedel-Crafts alkylation, what leads to the rearrangement of the alkyl group?
In Friedel-Crafts alkylation, what leads to the rearrangement of the alkyl group?
One advantage of Friedel-Crafts acylation over alkylation is:
One advantage of Friedel-Crafts acylation over alkylation is:
What is a common drawback of Friedel-Crafts alkylation when dealing with NH2, NHR, or NR2 substituted benzene rings?
What is a common drawback of Friedel-Crafts alkylation when dealing with NH2, NHR, or NR2 substituted benzene rings?
What effect does the +I effect of CH3 group have in Friedel-Crafts alkylation?
What effect does the +I effect of CH3 group have in Friedel-Crafts alkylation?
Flashcards
Rate-determining step in halogenation of benzene?
Rate-determining step in halogenation of benzene?
Addition of Cl to FeCl3
Role of catalyst in Friedel-Crafts Alkylation?
Role of catalyst in Friedel-Crafts Alkylation?
Speed up the formation of the electrophile
Lewis acid in halogenation mechanism?
Lewis acid in halogenation mechanism?
FeCl3
Product of nitration of nitrobenzene?
Product of nitration of nitrobenzene?
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Purpose of H2SO4 in sulphonation of benzene?
Purpose of H2SO4 in sulphonation of benzene?
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Major disadvantage of Friedel-Crafts alkylation?
Major disadvantage of Friedel-Crafts alkylation?
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Step involving formation of a σ Complex during SE aromatic substitution?
Step involving formation of a σ Complex during SE aromatic substitution?
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Advantage of Friedel-Crafts acylation over alkylation?
Advantage of Friedel-Crafts acylation over alkylation?
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Common drawback of Friedel-Crafts alkylation with NH2 substituted benzene rings?
Common drawback of Friedel-Crafts alkylation with NH2 substituted benzene rings?
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Effect of +I effect of CH3 group in Friedel-Crafts alkylation?
Effect of +I effect of CH3 group in Friedel-Crafts alkylation?
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