Organic Chemistry Practice Questions

Organic Chemistry Practice Questions

• Skraup synthesis is used to synthesize quinoline.
• Pyridine is more basic than aniline.
• Reaction of imidazole with HNO3/H2SO4 gives 4-nitroimidazole.
• Furan is the most aromatic heterocycle among furan, pyrrole, and thiophene.
• Electrophilic substitution in furan occurs at the 2nd position.
• Reaction of quinoline to 2-aminoquinoline uses NaNH2/liquid ammonia.
• The starting material for Paal-Knoor synthesis of furan is a 1,4-diketo compound.

Aromaticity

• The correct order of aromaticity is Thiophene > Pyrrole > Furan.
• Pyridine-3-carboxylic acid is the product of the given reaction.
• 2,3-dihydropyrrole is non-aromatic in nature.

Amino Acids and Polymers

• Tyrosine is the phenolic group-containing amino acid.
• Syndiotactic polymers are propylene polymers in which methyl groups have alternate positions along the chain.
• Thermoplastics are soft and viscous when heated.

Nucleic Acids and Steroids

• Isobutyryl group is used to protect cytosine.
• Steroidal ester hydrolysis exhibits the following order of reactivity: equatorial groups are hydrolyzed faster than axial groups.
• The steroid core in cortisone is pregnane.
• Bromination of 5a-cholestan-3-one yields a 3-bromo derivative.
• Catalytic hydrogenation of steroidal ketones under neutral conditions gives a trans-di equatorial diol.

Other Practice Questions (Cosmetics and Pharmaceuticals)

• Acacia is a polysaccharide emulsifying agent.
• The ratio of oil:water:gum for mineral oil emulsion is 3:2:1.
• The pH range for Pseudomonas aeruginosa contamination is 6-8.
• Schedule M(II) in the D and C Act lists cosmetic products.
• Oral pharmaceutical suspensions are thermodynamically unstable.
• The dispersed phase in a biphasic liquid is the internal phase.
• Emulsifier with HLB 12 promotes the formation of oil-in-water (o/w) emulsions.
• The dosage form for rectal administration is a suppository.
• Drug penetration through skin can be altered by factors including decreasing the resistance of the stratum corneum, changing its hydration and structure of lipids.
• Factors affecting systemic absorption of drug following rectal administration include pKa of drug, lipid-water partition coefficient, and colonic & gastrointestinal pH.
• Cocoa butter, gelatin, and polyethylene glycol are commonly used suppository bases.
• Objectives of sensorial testing include interpreting consumer responses and assessing product acceptance, as well as checking for safety.
• Hydrofluoroalkanes are commonly used propellants in aerosols.
• Diagnostic, prophetic, and photopatch tests are used in sensitivity testing of cosmetics.
• Quality control tests for aerosols include disintegration, melting point, discharge rate, and dissolution.
• Semisolids are evaluated for properties like pH, viscosity, spreadability, and crushing strength.

Pharmaceutical Biotechnology

• The stir in an airlift fermenter is done using mechanical stirrer.
• Equipment sterilization, media preparation, recovery, and purification are part of the downstream process.
• Oral polio vaccine (Sabin) is a live vaccine.
• BCG is used for protection against tuberculosis.
• Restriction enzymes are called molecular scissors.
• Type II restriction enzymes are used in recombinant DNA experiments.
• Ligase enzyme joins foreign genes in a vector.
• Plasmids are obtained from bacteria.
• Cosmids are obtained from bacteria and viruses.
• Post-translational modifications are absent in bacteria.
• The first step in PCR is denaturation.
• Enzyme immobilization is an eco-friendly process.

Test your knowledge on organic chemistry with these practice questions covering topics like aromaticity, amino acids, and polymer chemistry. Challenge yourself with specific reactions and synthesis methods, and solidify your understanding of fundamental concepts in the field.