16 Questions
What is the most common mechanism of drug absorption?
Passive non-ionic diffusion
Which factor does NOT influence drug absorption?
Temperature
Which dosage forms are exceptions to the USP disintegration guidelines?
Troches and chewable tablets
What is dissolution in the context of drug absorption?
The process where the drug dissolves in a solvent
What is the dissolution medium pH range described in USP chapter for oral drug absorption testing?
1.2 – 6.8
What is the most common apparatus described in USP for dissolution testing in oral drug absorption?
Apparatus 1 and Apparatus 2
What is the rate-limiting step for low water soluble (hydrophobic) drugs in oral drug absorption?
Dissolution
What is the rate-limiting step for high water soluble (hydrophilic) drugs in oral drug absorption?
Permeability
What is the most rapid absorbing oral dosage form among solutions, suspensions, capsules, and tablets?
Solutions
What must happen before absorption can take place in solid dosage forms like capsules and tablets?
Shell must release the drug particles
What does bioavailability indicate for oral products?
The fractional extent to which a dose of drug reaches the site of action
What does bioequivalence refer to in relation to drug formulations?
Comparing the bioavailability of the same drug in two different formulations
What are the three indices of bioavailability?
Cmax, tmax, AUC
What does the Biopharmaceutics Classification System (BCS) classify based on?
Solubility and permeability
What is the plasma concentration time-curve difference between controlled-release and immediate release products?
Controlled-release products show a more sustained release over time
What is the rate-limiting step for low water soluble (hydrophobic) drugs in oral drug absorption?
Dissolution
Test your knowledge of the factors influencing oral drug absorption with this quiz. Explore the impact of molecular size, shape, ionization, and lipid solubility on the process of drug absorption in the gastrointestinal tract.
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